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Tustin AW, Cannon DL. Analysis of biomonitoring data to assess employer compliance with OSHA's permissible exposure limits for air contaminants. Am J Ind Med. 2021;doi: 10.1002/ajim.23317.
Tustin, A. W., & Cannon, D. L. (2021). Analysis of biomonitoring data to assess employer compliance with OSHA's permissible exposure limits for air contaminants. American journal of industrial medicine, . https://doi.org/10.1002/ajim.23317
Tustin, Aaron W, and Cannon, Dawn L. "Analysis of biomonitoring data to assess employer compliance with OSHA's permissible exposure limits for air contaminants." American journal of industrial medicine vol. (2021). doi: https://doi.org/10.1002/ajim.23317
Tustin AW, Cannon DL. Analysis of biomonitoring data to assess employer compliance with OSHA's permissible exposure limits for air contaminants. Am J Ind Med. 2021 Dec 05; doi: 10.1002/ajim.23317. Epub 2021 Dec 05. PMID: 34865238.
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Am J Ind Med. 2021 Dec 05; doi: 10.1002/ajim.23317. Epub 2021 Dec 05.

Analysis of biomonitoring data to assess employer compliance with OSHA's permissible exposure limits for air contaminants.

American journal of industrial medicine

Aaron W Tustin, Dawn L Cannon

Affiliations

  1. Office of Occupational Medicine and Nursing, Directorate of Technical Support and Emergency Management, Occupational Safety and Health Administration, Washington, District of Columbia, USA.

PMID: 34865238 DOI: 10.1002/ajim.23317

Abstract

BACKGROUND: The Occupational Safety and Health Administration (OSHA) regulates exposures to hazardous chemicals in workplace air. When contemporaneous exposure measurements are unavailable, retrospective analysis of biomarkers could provide valuable information about workers' exposures.

METHODS: Single-compartment pharmacokinetic (PK) models were created to relate the concentration of a chemical in the air to the concentration of the chemical or its metabolite in workers' blood or urine. OSHA utilized the PK models in investigations of three fatal incidents in which workers were exposed to nickel carbonyl, methyl bromide, or styrene. To obtain the minimum plausible estimate of each exposure, OSHA used conservative assumptions about parameters such as workers' inhalation rates, baseline levels of biomarker, and chemicals' volumes of distribution.

RESULTS: OSHA analyzed a worker's urinary nickel concentration and concluded that his 8-h time-weighted average exposure to nickel carbonyl was at least 0.06 mg/m

CONCLUSIONS: Analysis of biomarkers via PK modeling enables retrospective evaluations of workers' acute exposures to hazardous chemicals. These techniques are useful to occupational regulators who assess employer compliance with mandatory exposure limits.

© 2021 Wiley Periodicals LLC.

Keywords: OSHA; biomonitoring; chemical exposure; permissible exposure limits; pharmacokinetic model

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