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Wang N, Hao F, Shi Y, et al. The Controversial Role of Polyploidy in Hepatocellular Carcinoma. Onco Targets Ther. 2021;14:5335-5344doi: 10.2147/OTT.S340435.
Wang, N., Hao, F., Shi, Y., & Wang, J. (2021). The Controversial Role of Polyploidy in Hepatocellular Carcinoma. OncoTargets and therapy, 145335-5344. https://doi.org/10.2147/OTT.S340435
Wang, Nan, et al. "The Controversial Role of Polyploidy in Hepatocellular Carcinoma." OncoTargets and therapy vol. 14 (2021): 5335-5344. doi: https://doi.org/10.2147/OTT.S340435
Wang N, Hao F, Shi Y, Wang J. The Controversial Role of Polyploidy in Hepatocellular Carcinoma. Onco Targets Ther. 2021 Nov 27;14:5335-5344. doi: 10.2147/OTT.S340435. eCollection 2021. PMID: 34866913; PMCID: PMC8636953.
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Onco Targets Ther. 2021 Nov 27;14:5335-5344. doi: 10.2147/OTT.S340435. eCollection 2021.

The Controversial Role of Polyploidy in Hepatocellular Carcinoma.

OncoTargets and therapy

Nan Wang, Fengjie Hao, Yan Shi, Junqing Wang

Affiliations

  1. Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.
  2. Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

PMID: 34866913 PMCID: PMC8636953 DOI: 10.2147/OTT.S340435

Abstract

Polyploidy, a physiological phenomenon in which cells contain more than two sets of homologous chromosomes, commonly exists in plants, fish, and amphibians but is rare in mammals. In humans, polyploid cells are detected commonly in specific organs or tissues including the heart, marrow, and liver. As the largest solid organ in the body, the liver is responsible for a myriad of functions, most of which are closely related to polyploid hepatocytes. It has been confirmed that polyploid hepatocytes are related to liver regeneration, homeostasis, terminal differentiation, and aging. Polyploid hepatocytes accumulate during the aging process as well as in chronically injured livers. The relationship between polyploid hepatocytes and hepatocellular carcinoma, the endpoint of most chronic liver diseases, is not yet fully understood. Recently, accumulated evidence has revealed that polyploid involves in the process of tumorigenesis and development. The study of the correlation and relationship between polyploidy hepatocytes and the development of hepatocellular carcinoma can potentially promote the prevention, early diagnosis, and treatment of hepatocellular carcinoma. In this review, we conclude the potential mechanisms of polyploid hepatocytes formation, focusing on the specific biological significance of polyploid hepatocytes. In addition, we examine recent discoveries that have begun to clarify the relevance between polyploid hepatocytes and hepatocellular carcinoma and discuss recent excellent findings that reveal the role of polyploid hepatocytes as resisters of hepatocellular carcinoma or as promoters of hepatocarcinogenesis.

© 2021 Wang et al.

Keywords: cancer; cell cycle; hepatocyte; liver; polyploidy

Conflict of interest statement

The authors report no conflicts of interest in this work.

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