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Liu D, Yu Q, Ning Q, et al. The relationship between . Drug Metab Rev. 2021;1-21doi: 10.1080/03602532.2021.2001493.
Liu, D., Yu, Q., Ning, Q., Liu, Z., & Song, J. (2021). The relationship between . Drug metabolism reviews, 1-21. https://doi.org/10.1080/03602532.2021.2001493
Liu, Dan, et al. "The relationship between ." Drug metabolism reviews vol. (2021): 1-21. doi: https://doi.org/10.1080/03602532.2021.2001493
Liu D, Yu Q, Ning Q, Liu Z, Song J. The relationship between . Drug Metab Rev. 2021 Nov 22;1-21. doi: 10.1080/03602532.2021.2001493. Epub 2021 Nov 22. PMID: 34807779.
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Drug Metab Rev. 2021 Nov 22;1-21. doi: 10.1080/03602532.2021.2001493. Epub 2021 Nov 22.

The relationship between .

Drug metabolism reviews

Dan Liu, Qi Yu, Qing Ning, Zhongqiu Liu, Jie Song

Affiliations

  1. Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, PR China.
  2. Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, PR China.
  3. Guangdong Key Laboratory for Translational Cancer Research of Chinese Medicine, Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China.

PMID: 34807779 DOI: 10.1080/03602532.2021.2001493

Abstract

UDP-glucuronyltransferase 1A1 (UGT1A1) is a member of the Phase II metabolic enzyme family and the only enzyme that can metabolize detoxified bilirubin. Inactivation and very low activity of UGT1A1 in the liver can be fatal or lead to lifelong Gilbert's syndrome (GS) and Crigler-Najjar syndrome (CN). To date, more than one hundred UGT1A1 polymorphisms have been discovered. Although most UGT1A1 polymorphisms are not fatal, which diseases might be associated with low activity UGT1A1 or UGT1A1 polymorphisms? This scientific topic has been studied for more than a hundred years, there are still many uncertainties. Herein, this article will summarize all the possibilities of

Keywords: Crigler–Najjar syndrome; Gilbert’s syndrome; UGT1A1; hepatobiliary disease; neurological disease; tumorigenesis

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