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Lipovsek M, Marcovich I, Elgoyhen AB. The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family. Front Cell Neurosci. 2021;15:785265doi: 10.3389/fncel.2021.785265.
Lipovsek, M., Marcovich, I., & Elgoyhen, A. B. (2021). The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family. Frontiers in cellular neuroscience, 15785265. https://doi.org/10.3389/fncel.2021.785265
Lipovsek, Marcela, et al. "The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family." Frontiers in cellular neuroscience vol. 15 (2021): 785265. doi: https://doi.org/10.3389/fncel.2021.785265
Lipovsek M, Marcovich I, Elgoyhen AB. The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family. Front Cell Neurosci. 2021 Nov 15;15:785265. doi: 10.3389/fncel.2021.785265. eCollection 2021. PMID: 34867208; PMCID: PMC8634148.
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Front Cell Neurosci. 2021 Nov 15;15:785265. doi: 10.3389/fncel.2021.785265. eCollection 2021.

The Hair Cell α9α10 Nicotinic Acetylcholine Receptor: Odd Cousin in an Old Family.

Frontiers in cellular neuroscience

Marcela Lipovsek, Irina Marcovich, Ana Belén Elgoyhen

Affiliations

  1. Ear Institute, Faculty of Brain Sciences, University College London, London, United Kingdom.
  2. Departments of Otolaryngology & Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.
  3. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres" (INGEBI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.

PMID: 34867208 PMCID: PMC8634148 DOI: 10.3389/fncel.2021.785265

Abstract

Nicotinic acetylcholine receptors (nAChRs) are a subfamily of pentameric ligand-gated ion channels with members identified in most eumetazoan clades. In vertebrates, they are divided into three subgroups, according to their main tissue of expression: neuronal, muscle and hair cell nAChRs. Each receptor subtype is composed of different subunits, encoded by paralogous genes. The latest to be identified are the α9 and α10 subunits, expressed in the mechanosensory hair cells of the inner ear and the lateral line, where they mediate efferent modulation. α9α10 nAChRs are the most divergent amongst all nicotinic receptors, showing marked differences in their degree of sequence conservation, their expression pattern, their subunit co-assembly rules and, most importantly, their functional properties. Here, we review recent advances in the understanding of the structure and evolution of nAChRs. We discuss the functional consequences of sequence divergence and conservation, with special emphasis on the hair cell α9α10 receptor, a seemingly distant cousin of neuronal and muscle nicotinic receptors. Finally, we highlight potential links between the evolution of the octavolateral system and the extreme divergence of vertebrate α9α10 receptors.

Copyright © 2021 Lipovsek, Marcovich and Elgoyhen.

Keywords: efferent system; evolution; hair cells; ion channel; nicotinic acetylcholine receptors

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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