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Clin Oral Implants Res. 2021 Nov 22; doi: 10.1111/clr.13881. Epub 2021 Nov 22.

Erythritol air polishing in the surgical treatment of peri-implantitis: A randomized controlled trial.

Clinical oral implants research

Diederik F M Hentenaar, Yvonne C M De Waal, Roy E Stewart, Arie Jan Van Winkelhoff, Henny J A Meijer, Gerry M Raghoebar

Affiliations

  1. Department of Oral and Maxillofacial Surgery, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  2. Center for Dentistry and Oral Hygiene, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  3. Department of Health Sciences, Community and Occupational Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

PMID: 34808006 DOI: 10.1111/clr.13881

Abstract

OBJECTIVES: To compare erythritol air polishing with implant surface cleansing using saline during the surgical treatment of peri-implantitis.

MATERIAL AND METHODS: During a resective surgical intervention, implant surfaces were randomly treated with either air polishing (test group n = 26 patients/53 implants) or saline-soaked cotton gauzes (control group n = 31 patients/ 40 implants). Primary outcome was change in mean bleeding on probing (BoP) from baseline to 12 months follow-up. Secondary outcomes were changes in mean suppuration on probing (SoP), plaque score (Plq), probing pocket depth (PPD), marginal bone loss (MBL), periodontal full-mouth scores (PFMS), and levels of 8 classical periodontal pathogens. Clinical and radiographical parameters were analyzed using multilevel regression analyses. Microbiological outcomes were analyzed using the Mann-Whitney U test.

RESULTS: No differences between the test and control group were found for BoP over 12 months of follow-up, nor for the secondary parameters Plq, PPD, and MBL. Between both groups, a significant difference was found for the levels of SoP (p = 0.035). No significant effect on microbiological levels was found. A total number of 6 implants were lost in the test group and 10 in the control group. At 1-year follow-up, a successful treatment outcome (PPD<5 mm, max 1 out of 6 sites BoP, no suppuration and no progressive bone loss >0.5 mm) was achieved for a total of 18 implants (19.2%).

CONCLUSIONS: Erythritol air polishing as implant surface cleansing method was not more effective than saline during resective surgical treatment of peri-implantitis in terms of clinical, radiographical, and microbiological parameters. Both therapies resulted in low treatment success.

TRIAL REGISTRY: https://www.trialregister.nl/ Identifier: NL8621.

© 2021 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.

Keywords: dental implant; intervention study; peri-implantitis; randomized controlled trial; surgery

References

  1. Amate-Fernández, P., Figueiredo, R., Blanc, V., Àlvarez, G., León, R., & Valmaseda-Castellón, E. (2021). Erythritol-enriched powder and oral biofilm regrowth on dental implants: an in vitro study. Medicina Oral, Patologia Oral Y Cirugia Bucal, 26, e602-e610. https://doi.org/10.4317/medoral.24622 - PubMed
  2. Charalampakis, G., & Belibasakis, G. N. (2015). Microbiome of peri-implant infections: Lessons from conventional, molecular and metagenomic analyses. Virulence, 6, 183-187. https://doi.org/10.4161/21505594.2014.980661 - PubMed
  3. Cosgarea, R., Jepsen, S., Fimmers, R., Bodea, A., Eick, S., & Sculean, A. (2021). Clinical outcomes following periodontal surgery and root surface decontamination by erythritol-based air polishing. A randomized, controlled, clinical pilot study. Clinical Oral Investigations, 25, 627-635. https://doi.org/10.1007/s00784-020-03533-9 - PubMed
  4. Drago, L., Bortolin, M., Taschieri, S., De Vecchi, E., Agrappi, S., Del Fabbro, M., Francetti, L., & Mattina, R. (2017). Erythritol/chlorhexidine combination reduces microbial biofilm and prevents its formation on titanium surfaces in vitro. Journal of Oral Pathology & Medicine, 46, 625-631. https://doi.org/10.1111/jop.12536 - PubMed
  5. Drago, L., Del Fabbro, M., Bortolin, M., Vassena, C., De Vecchi, E., & Taschieri, S. (2014). Biofilm removal and antimicrobial activity of two different air polishing powders: An in vitro study. Journal of Periodontology, 85, e363-e369. https://doi.org/10.1902/jop.2014.140134 - PubMed
  6. Esposito, M., Grusovin, M. G., & Worthington, H. V. (2012). Treatment of peri-implantitis: What interventions are effective? A cochrane systematic review. European Journal of Oral Implantology, 5, S21-S41. - PubMed
  7. Garaicoa-Pazmino, C., Sinjab, K., & Wang, H.-L. (2019). Current protocols for the treatment of peri-implantitis. Current Oral Health Reports, 6, 209-217. https://doi.org/10.1007/s40496-019-00227-4 - PubMed
  8. Hägi, T. T., Hofmänner, P., Salvi, G. E., Ramseier, C. A., & Sculean, A. (2013). Clinical outcomes following subgingival application of a novel erythritol powder by means of air polishing in supportive periodontal therapy: A randomized, controlled clinical study. Quintessence International, 44, 753-761. https://doi.org/10.3290/j.qi.a30606 - PubMed
  9. Hashino, E., Kuboniwa, M., Alghamdi, S. A., Yamaguchi, M., Yamamoto, R., Cho, H., & Amano, A. (2013). Erythritol alters microstructure and metabolomic profiles of biofilm composed of Streptococcus gordonii and Porphyromonas gingivalis. Molecular Oral Microbiology, 28, 435-451. https://doi.org/10.1111/omi.12037 - PubMed
  10. Hentenaar, D., De Waal, Y., Stewart, R. E., Van Winkelhoff, A. J., Meijer, H., & Raghoebar, G. M. (2021). Erythritol airpolishing in the non-surgical treatment of peri-implantitis: A randomized controlled trial. Clinical Oral Implants Research, 32, 840-852. https://doi.org/10.1111/clr.13757 - PubMed
  11. Hentenaar, D. F. M., De Waal, Y. C. M., Strooker, H., Meijer, H. J. A., Van Winkelhoff, A. J., & Raghoebar, G. M. (2017). Implant decontamination with phosphoric acid during surgical peri-implantitis treatment: A RCT. International Journal of Implant Dentistry, 3, 33-35. https://doi.org/10.1186/s40729-017-0091-5 - PubMed
  12. Jentsch, H. F. R., Flechsig, C., Kette, B., & Eick, S. (2020). Adjunctive air-polishing with erythritol in nonsurgical periodontal therapy: a randomized clinical trial. BMC Oral Health, 20, 364. https://doi.org/10.1186/s12903-020-01363-5 - PubMed
  13. Khan, A., Goyal, A., Currell, S. D., & Sharma, D. (2020). Management of peri-implantitis lesions without the use of systemic antibiotics: A systematic review. Dentistry Journal, 8, 106. https://doi.org/10.3390/dj8030106 - PubMed
  14. Khoury, F., Keeve, P. L., Ramanauskaite, A., Schwarz, F., Koo, K. T., Sculean, A., & Romanos, G. (2019). Surgical treatment of peri-implantitis - Consensus report of working group 4. International Dental Journal, 69, 18-22. https://doi.org/10.1111/idj.12505 - PubMed
  15. Koo, K. T., Khoury, F., Keeve, P. L., Schwarz, F., Ramanauskaite, A., Sculean, A., & Romanos, G. (2019). Implant surface decontamination by surgical treatment of periimplantitis: A literature review. Implant Dentistry, 28, 173-176. https://doi.org/10.1097/ID.0000000000000840 - PubMed
  16. Lasserre, J. F., Brecx, M. C., & Toma, S. (2020). Implantoplasty versus glycine air abrasion for the surgical treatment of peri-implantitis: A randomized clinical trial. The International Journal of Oral & Maxillofacial Implants, 35, 197-206. https://doi.org/10.11607/jomi.6677 - PubMed
  17. Louropoulou, A., Slot, D. E., & Van der Weijden, F. (2014). The effects of mechanical instruments on contaminated titanium dental implant surfaces: A systematic review. Clinical Oral Implants Research, 25(10), 1149-1160. https://doi.org/10.1111/clr.12224 - PubMed
  18. Maas, C. J. M., & Hox, J. J. (2005). Sufficient sample sizes for multilevel modeling. Methodology: European Journal of Research Methods for the Behavioral and Social Sciences, 1, 86-92. https://doi.org/10.1027/1614-2241.1.3.86 - PubMed
  19. Matsubara, V. H., Leong, B. W., Leong, M. J. L., Lawrence, Z., Becker, T., & Quaranta, A. (2020). Cleaning potential of different air abrasive powders and their impact on implant surface roughness. Clinical Implant Dentistry and Related Research, 22, 96-104. https://doi.org/10.1111/cid.12875 - PubMed
  20. Matthes, R., Duske, K., Kebede, T. G., Pink, C., von Schlüter, R., Woedtke, T., Weltmann, K. D., Kocher, T., & Jablonowski, L. (2017). Osteoblast growth, after cleaning of biofilm-covered titanium discs with air polishing and cold plasma. Journal of Clinical Periodontology, 44, 672-680. https://doi.org/10.1111/jcpe.12720 - PubMed
  21. Mensi, M., Cochis, A., Sordillo, A., Uberti, F., & Rimondini, L. (2018). Biofilm removal and bacterial re-colonization inhibition of a novel erythritol/chlorhexidine air polishing powder on titanium disks. Materials, 11, 1510. https://doi.org/10.3390/ma11091510 - PubMed
  22. Mensi, M., Scotti, E., Sordillo, A., Calza, S., Guarnelli, M. E., Fabbri, C., Farina, R., & Trombelli, L. (2021). Efficacy of the additional use of subgingival air polishing with erythritol powder in the treatment of periodontitis patients: A randomized controlled clinical trial. Clinical Oral Investigations, 25, 729-736. https://doi.org/10.1007/s00784-020-03648-z - PubMed
  23. Moharrami, M., Perrotti, V., Iaculli, F., Love, R. M., & Quaranta, A. (2019). Effects of air abrasive decontamination on titanium surfaces: A systematic review of in vitro studies. Clinical Implant Dentistry and Related Research, 21, 398-421. https://doi.org/10.1111/cid.12747 - PubMed
  24. Monje, A., Pons, R., Insua, A., Nart, J., Wang, H. L., & Schwarz, F. (2019). Morphology and severity of peri-implantitis bone defects. Clinical Implant Dentistry and Related Research, 21, 635-643. https://doi.org/10.1111/cid.12791 - PubMed
  25. Müller, N., Moëne, R., Cancela, J. A., & Mombelli, A. (2014). Subgingival air-polishing with erythritol during periodontal maintenance: Randomized clinical trial of twelve months. Journal of Clinical Periodontology, 41, 883-889. https://doi.org/10.1111/jcpe.12289 - PubMed
  26. Muthukuru, M., Zainvi, A., Esplugues, E. O., & Flemmig, T. F. (2012). Non-surgical therapy for the management of peri-implantitis: A systematic review. Clinical Oral Implants Research, 23, 77-83. https://doi.org/10.1111/j.1600-0501.2012.02542.x - PubMed
  27. Papadopoulos, C. A., Vouros, I., Menexes, G., & Konstantinidis, A. (2015). The utilization of a diode laser in the surgical treatment of peri-implantitis. A randomized clinical trial. Clinical Oral Investigations, 19, 1851-1860. https://doi.org/10.1007/s00784-014-1397-9 - PubMed
  28. Park, E. J., Kwon, E. Y., Kim, H. J., Lee, J. Y., Choi, J., & Joo, J. Y. (2018). Clinical and microbiological effects of the supplementary use of an erythritol powder air polishing device in non-surgical periodontal therapy: A randomized clinical trial. Journal of Periodontal & Implant Science, 48, 295-304. https://doi.org/10.5051/jpis.2018.48.5.295 - PubMed
  29. Petersilka, G. J. (2011). Subgingival air polishing in the treatment of periodontal biofilm infections. Periodontology, 2000(55), 124-142. https://doi.org/10.1111/j.1600-0757.2010.00342.x - PubMed
  30. Pranno, N., Cristalli, M. P., Mengoni, F., Sauzullo, I., Annibali, S., Polimeni, A., & La Monaca, G. (2021). Comparison of the effects of air-powder abrasion, chemical decontamination, or their combination in open-flap surface decontamination of implants failed for peri-implantitis: an ex vivo study. Clinical Oral Investigations, 25(5), 2667-2676. https://doi.org/10.1007/s00784-020-03578-w - PubMed
  31. Ramanauskaite, A., Obreja, K., & Schwarz, F. (2020). Surgical management of peri-implantitis. Current Oral Health Reports, 7, 283-303. https://doi.org/10.1007/s40496-020-00278-y - PubMed
  32. Sanz, M., & Chapple, I. L.; Working Group 4 of the VIII European Workshop on Periodontology (2012). Clinical Research on Peri-Implant Diseases: Consensus Report of Working Group 4. Journal of Clinical Periodontology, 39, 202-206. https://doi.org/10.1111/j.1600-051X.2011.01837.x - PubMed
  33. Sanz-Martín, I., Paeng, K., Park, H., Cha, J. K., Jung, U. W., & Sanz, M. (2021). Significance of implant design on the efficacy of different peri-implantitis decontamination protocols. Clinical Oral Investigations, 25, 3589-3597. https://doi.org/10.1007/s00784-020-03681-y - PubMed
  34. Scherbaum, C. A., & Ferreter, J. M. (2009). Estimating statistical power and required sample sizes for organizational research using multilevel modeling. Organizational Research Methods, 12, 347-367. https://doi.org/10.1177/1094428107308906 - PubMed
  35. Schulz, K. F., Altman, D. G., & Moher, D. (2010). CONSORT 2010 statement: Updated guidelines for reporting parallel group randomized trials. Annals of Internal Medicine, 152, 726-732. - PubMed
  36. Schwarz, F., Herten, M., Sager, M., Bieling, K., Sculean, A., & Becker, J. (2007). Comparison of naturally occurring and ligature-induced peri-implantitis bone defects in humans and dogs.". Clinical Oral Implants Research, 18, 161-170. https://doi.org/10.1111/j.1600-0501.2006.01320.x - PubMed
  37. Söderling, E. M., & Hietala-Lenkkeri, A. M. (2010). Xylitol and erythritol decrease adherence of polysaccharide-producing oral streptococci. Current microbiology, 60, 25-29. https://doi.org/10.1007/s00284-009-9496-6 - PubMed
  38. Tastepe, C. S., Lin, X., Donnet, M., Doulabi, B. Z., Wismeijer, D., & Liu, Y. (2018). Re-establishment of biocompatibility of the in vitro contaminated titanium surface using osteoconductive powders with air-abrasive treatment. The Journal of Oral Implantology, 44, 94-101. https://doi.org/10.1563/aaid-joi-D-17-00128 - PubMed
  39. Toma, S., Brecx, M. C., & Lasserre, J. F. (2019). Clinical evaluation of three surgical modalities in the treatment of peri-implantitis: A randomized controlled clinical trial. Journal of Clinical Medicine, 8, 966. https://doi.org/10.3390/jcm8070966 - PubMed
  40. Tomasi, C., Regidor, E., Ortiz-Vigón, A., & Derks, J. (2019). Efficacy of reconstructive surgical therapy at peri-implantitis-related bone defects. A systematic review and meta-analysis. Journal of Clinical Periodontology, 46, 340-356. https://doi.org/10.1111/jcpe.13070 - PubMed
  41. Tuchscheerer, V., Eickholz, P., Dannewitz, B., Ratka, C., Zuhr, O., & Petsos, H. (2021). In vitro surgical and non-surgical air-polishing efficacy for implant surface decontamination in three different defect configurations. Clinical Oral Investigations, 25, 1743-1754. https://doi.org/10.1007/s00784-020-03476-1 - PubMed
  42. de Waal, Y. C., Raghoebar, G. M., Huddleston Slater, J. J., Meijer, H. J., Winkel, E. G., & Van Winkelhoff, A. J. (2013). Implant decontamination during surgical peri-implantitis treatment: A randomized, double-blind, placebo-controlled trial. Journal of Clinical Periodontology, 40, 186-195. https://doi.org/10.1111/jcpe.12034 - PubMed
  43. de Waal, Y. C., Raghoebar, G. M., Meijer, H. J., Winkel, E. G., & Van Winkelhoff, A. J. (2015). Implant decontamination with 2% chlorhexidine during surgical peri-implantitis treatment: A randomized, double-blind, controlled trial. Clinical Oral Implants Research, 26, 1015-1023. https://doi.org/10.1111/clr.12419 - PubMed

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