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van der Heijden TGW, Chilunga FP, Meeks KAC, et al. The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study. Int J Environ Res Public Health. 2021;18(22)doi: 10.3390/ijerph182211996.
van der Heijden, T. G. W., Chilunga, F. P., Meeks, K. A. C., Addo, J., Danquah, I., Beune, E. J., Bahendeka, S. K., Klipstein-Grobusch, K., Mockenhaupt, F. P., Waltz, M. M., & Agyemang, C. (2021). The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study. International journal of environmental research and public health, 18(22), . https://doi.org/10.3390/ijerph182211996
van der Heijden, Thijs G W, et al. "The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study." International journal of environmental research and public health vol. 18,22 (2021). doi: https://doi.org/10.3390/ijerph182211996
van der Heijden TGW, Chilunga FP, Meeks KAC, Addo J, Danquah I, Beune EJ, Bahendeka SK, Klipstein-Grobusch K, Mockenhaupt FP, Waltz MM, Agyemang C. The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study. Int J Environ Res Public Health. 2021 Nov 15;18(22). doi: 10.3390/ijerph182211996. PMID: 34831754; PMCID: PMC8622143.
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Int J Environ Res Public Health. 2021 Nov 15;18(22). doi: 10.3390/ijerph182211996.

The Magnitude and Directions of the Associations between Early Life Factors and Metabolic Syndrome Differ across Geographical Locations among Migrant and Non-Migrant Ghanaians-The RODAM Study.

International journal of environmental research and public health

Thijs G W van der Heijden, Felix P Chilunga, Karlijn A C Meeks, Juliet Addo, Ina Danquah, Erik J Beune, Silver K Bahendeka, Kerstin Klipstein-Grobusch, Frank P Mockenhaupt, Mitzi M Waltz, Charles Agyemang

Affiliations

  1. Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Center, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
  2. Center for Research on Genomics & Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20894, USA.
  3. Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London WC1E 7HT, UK.
  4. Heidelberg Institute of Global Health (HIGH), Faculty of Medicine and University Hospital, Heidelberg University, 69120 Heidelberg, Germany.
  5. Mother Kevin Postgraduate Medical School (MKPGMS), Uganda Martyrs University, Kampala 32297, Uganda.
  6. Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht University, 3584 CG Utrecht, The Netherlands.
  7. Division of Epidemiology and Biostatistics, Department of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2193, South Africa.
  8. Institute of Tropical Medicine and International Health, Charité-University Medicine Berlin, 13353 Berlin, Germany.
  9. Athena Institute, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.

PMID: 34831754 PMCID: PMC8622143 DOI: 10.3390/ijerph182211996

Abstract

BACKGROUND: Early-life factors (ELFs) such as childhood nutrition and childhood socio-economic status could be the drivers of the increase in metabolic syndrome (MetSyn) among African populations, but data are lacking. This study evaluated whether markers of childhood nutritional status and childhood socio-economic status were associated with MetSyn in adulthood among migrant Ghanaians living in Europe and non-migrant Ghanaians living in Ghana.

METHODS: Data from the Research on Obesity and Diabetes among African Migrants (RODAM) study, involving 2008 migrants and 2320 non-migrants aged ≥25 years, were analysed for this study. We used leg-length to height ratio (LHR), which is an anthropometric marker of childhood nutritional status, and parental education, which is a marker of childhood socio-economic status, as proxies. Adjusted odds ratios (AOR) and 95% confidence intervals (95% CI) were calculated by logistic regression with adjustments for demographic and lifestyle factors.

RESULTS: Parental education was higher among Ghanaians in Europe than among residents in rural and urban Ghana. The prevalence of MetSyn was 18.5%, 27.7% and 33.5% for rural, urban, and migrant residents, respectively. LHR was inversely associated with MetSyn among migrants. Compared with high paternal education, individuals with low paternal education had lower odds of MetSyn in migrants (AOR 0.71 95% CI 0.54-0.94). In contrast, compared with high maternal education, individuals with intermediate maternal education had higher odds of MetSyn in urban Ghanaians (AOR 4.53 95% CI 1.50-3.74). No associations were found among rural Ghanaians.

CONCLUSION: The magnitude and direction of the associations between ELFs and MetSyn differ across geographical locations. Intermediate maternal education was positively associated with MetSyn among urban Ghanaians, while LHR and low paternal education were inversely associated with MetSyn among migrant Ghanaians. Further research into the interplay of genetics, environment and behaviour is needed to elucidate the underlying pathological mechanisms of MetSyn amongst migrants.

Keywords: diabetes; early life factors; metabolic syndrome; migration; obesity

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