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Reddy SC, Midha N, Chhabra V, et al. Amlodipine Induced Gum Hypertrophy - A Rare Case Report. Curr Drug Saf. 2021;doi: 10.2174/1574886316666211122125215.
Reddy, S. C., Midha, N., Chhabra, V., Kumar, D., & Bohra, G. K. (2021). Amlodipine Induced Gum Hypertrophy - A Rare Case Report. Current drug safety, . https://doi.org/10.2174/1574886316666211122125215
Reddy, Suryanarayana Challa, et al. "Amlodipine Induced Gum Hypertrophy - A Rare Case Report." Current drug safety vol. (2021). doi: https://doi.org/10.2174/1574886316666211122125215
Reddy SC, Midha N, Chhabra V, Kumar D, Bohra GK. Amlodipine Induced Gum Hypertrophy - A Rare Case Report. Curr Drug Saf. 2021 Nov 22; doi: 10.2174/1574886316666211122125215. Epub 2021 Nov 22. PMID: 34809550.
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Curr Drug Saf. 2021 Nov 22; doi: 10.2174/1574886316666211122125215. Epub 2021 Nov 22.

Amlodipine Induced Gum Hypertrophy - A Rare Case Report.

Current drug safety

Suryanarayana Challa Reddy, Naresh Midha, Vivek Chhabra, Deepak Kumar, Gopal Krishna Bohra

Affiliations

  1. Department of Internal Medicine, University of Maryland Medical Centre Midtown Campus, Baltimore. United States.
  2. All India Institute of Medical Sciences Jodhpur, Jodhpur Rajasthan. India.

PMID: 34809550 DOI: 10.2174/1574886316666211122125215

Abstract

BACKGROUND: DIGO or drug-induced gingival overgrowth occurs as a side effect of certain drugs. Until now, the etiology of drug-induced gingival overgrowth is not clearly understood. Among the calcium channel blockers, nifedipine has been shown to be most frequently associated with drug-induced gingival hyperplasia. Amlodipine is a comparatively newer calcium channel blocker that witha longer duration of action and lesser side effects as compared to nifedipine. There are only certain case reports of amlodipine-induced gum hyperplasia.

CASE PRESENTATION: We report a case of amlodipine-induced gum hyperplasia in a 66-year-old hypertensive patient taking amlodipine at a dose of 5 mg once a day. There was significant regression of gum hypertrophy after substitution of amlodipine by Losartan.

CONCLUSION: Amlodipine is one of the commonly prescribed antihypertensive drugs, and gingival hyperplasia is one overlooked side effect in patients taking amlodipine. Awareness of this potential side effect of amlodipine may be helpful to reduce the anxiety of patients and the cost of diagnostic procedures.

Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Keywords: Calcium channel blockers; amlodipine; anticonvulsants; antihypertensive; drug induced gingival overgrowth; immunosuppressive

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