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Chang PC, Lin SY. A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report. Int J Environ Res Public Health. 2021;18(22)doi: 10.3390/ijerph182212158.
Chang, P. C., & Lin, S. Y. (2021). A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report. International journal of environmental research and public health, 18(22), . https://doi.org/10.3390/ijerph182212158
Chang, Pei-Ching, and Lin, Shiao-Yu. "A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report." International journal of environmental research and public health vol. 18,22 (2021). doi: https://doi.org/10.3390/ijerph182212158
Chang PC, Lin SY. A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report. Int J Environ Res Public Health. 2021 Nov 19;18(22). doi: 10.3390/ijerph182212158. PMID: 34831922; PMCID: PMC8621981.
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Int J Environ Res Public Health. 2021 Nov 19;18(22). doi: 10.3390/ijerph182212158.

A Long-Term Follow-Up of Dental and Craniofacial Disturbances after Cancer Therapy in a Pediatric Rhabdomyosarcoma Patient: Case Report.

International journal of environmental research and public health

Pei-Ching Chang, Shiao-Yu Lin

Affiliations

  1. Department of Pediatric Dentistry, Taoyuan Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan.
  2. Department of Pediatric Dentistry, Lin-Kou Chang Gung Memorial Hospital, Taoyuan City 33305, Taiwan.

PMID: 34831922 PMCID: PMC8621981 DOI: 10.3390/ijerph182212158

Abstract

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. A boy aged seven years and five months was diagnosed with stage three group III embryonal parameningeal RMS with intracranial extension. He received chemotherapy for 23 weeks in combination with localized radiotherapy during the inductive phase of nine weeks (a total tumor dose of 5040 cGy). Three months later, he was referred to the department of pediatric dentistry for radiation-induced caries, the treatment of which was later terminated because of severe trismus and radiation-induced oropharyngeal mucositis. Three years later, the patient returned for the fitting of a prosthesis because of mastication problems. The dental treatments performed included: extraction, banding, composite resin restorations, root canal fillings, and stainless steel crown fabrication. An interim denture was fitted due to the poor retention of the fixed prosthesis. As the patient grew older, they developed facial asymmetry as a result of the prominent atrophy of their right cheek. By the age of 32, they had lost multiple teeth and exhibited severe facial deformity. Therefore, it is essential not only to involve a multidisciplinary medical team before, during, and after cancer therapy, but also to initiate long-term follow-ups given the potential effects of late sequelae after chemoradiation in multiple developmental areas.

Keywords: chemoradiation therapy; craniofacial disturbance; dental disturbance; rhabdomyosarcoma

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