Display options
Share it on

Int J Angiol. 2021 Aug 25;30(3):177-186. doi: 10.1055/s-0041-1731273. eCollection 2021 Sep.

Current Status of Primary, Secondary, and Tertiary Prevention of Coronary Artery Disease.

The International journal of angiology : official publication of the International College of Angiology, Inc

Kailash Prasad

Affiliations

  1. Department of Physiology (APP), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.

PMID: 34776817 PMCID: PMC8580611 DOI: 10.1055/s-0041-1731273

Abstract

Fifty percent of all death from cardiovascular diseases is due to coronary artery disease (CAD). This is avoidable if early identification is made. Preventive health care has a major role in the fight against CAD. Atherosclerosis and atherosclerotic plaque rupture are involved in the development of CAD. Modifiable risk factors for CAD are dyslipidemia, diabetes, hypertension, cigarette smoking, obesity, chronic renal disease, chronic infection, high C-reactive protein, and hyperhomocysteinemia. CAD can be prevented by modification of risk factors. This paper defines the primary, secondary, and tertiary prevention of CAD. It discusses the mechanism of risk factor-induced atherosclerosis. This paper describes the CAD risk score and its use in the selection of individuals for primary prevention of CAD. Guidelines for primary, secondary, and tertiary prevention of CAD have been described. Modification of risk factors and use of guidelines for prevention of CAD would prevent, regress, and slow down the progression of CAD, improve the quality of life of patient, and reduce the health care cost.

International College of Angiology. This article is published by Thieme.

Keywords: atherosclerosis; coronary artery disease; guidelines for prevention; modifiable risk factors of CAD; primary prevention; quality of life; secondary prevention; tertiary prevention

Conflict of interest statement

Conflict of Interest None declared.

References

  1. Cardiovasc Drug Rev. 2006 Spring;24(1):33-50 - PubMed
  2. Angiology. 2015 Sep;66(8):753-8 - PubMed
  3. Int J Angiol. 2018 Mar;27(1):1-12 - PubMed
  4. Hypertension. 2017 Aug;70(2):293-299 - PubMed
  5. J Biol Chem. 1989 Apr 15;264(11):6325-33 - PubMed
  6. Atherosclerosis. 2010 Mar;209(1):173-7 - PubMed
  7. Am J Clin Nutr. 2001 Sep;74(3):402-8 - PubMed
  8. BMJ. 2013 Jan 18;346:f10 - PubMed
  9. J Chronic Dis. 1974 Mar;27(3):103-14 - PubMed
  10. Chin J Physiol. 2003 Sep 30;46(3):129-36 - PubMed
  11. Circ Res. 1999 Mar 19;84(5):489-97 - PubMed
  12. Annu Rev Cell Biol. 1994;10:405-55 - PubMed
  13. J Immunol. 1981 Sep;127(3):1250-5 - PubMed
  14. Am J Cardiol. 1995 Jan 15;75(2):132-6 - PubMed
  15. Circulation. 1996 Apr 1;93(7):1346-53 - PubMed
  16. Lipids. 1991 Dec;26(12):1071-5 - PubMed
  17. J Int Med Res. 2007 Jul-Aug;35(4):482-9 - PubMed
  18. Circulation. 2011 Nov 29;124(22):2458-73 - PubMed
  19. Pharmacol Biochem Behav. 2011 Oct;99(4):659-64 - PubMed
  20. J Cardiovasc Pharmacol Ther. 2007 Dec;12(4):304-13 - PubMed
  21. Int J Mol Sci. 2014 Dec 26;16(1):378-400 - PubMed
  22. PLoS One. 2015 Mar 17;10(3):e0121971 - PubMed
  23. Oxid Med Cell Longev. 2011;2011:194586 - PubMed
  24. BMJ. 1989 Mar 25;298(6676):784-8 - PubMed
  25. Int J Exp Pathol. 1991 Feb;72(1):1-7 - PubMed
  26. Vasc Health Risk Manag. 2016 May 06;12:171-83 - PubMed
  27. Atherosclerosis. 2001 Jul;157(1):23-9 - PubMed
  28. Prostaglandins. 1987 Jun;33(6):931-9 - PubMed
  29. Clin Endocrinol Metab. 1976 Jul;5(2):367-75 - PubMed
  30. Circ Res. 2006 Jun 9;98(11):1352-64 - PubMed
  31. Arterioscler Thromb Vasc Biol. 1997 Oct;17(10):2167-76 - PubMed
  32. Atherosclerosis. 2012 Apr;221(2):496-502 - PubMed
  33. Microb Pathog. 1996 Sep;21(3):215-21 - PubMed
  34. Curr Opin Lipidol. 2011 Aug;22(4):254-61 - PubMed
  35. Clin Sci (Lond). 1995 Apr;88(4):485-9 - PubMed
  36. Biochem Biophys Res Commun. 2004 Jun 4;318(3):680-3 - PubMed
  37. Nat Rev Nephrol. 2011 Jan;7(1):45-54 - PubMed
  38. Mol Med. 2006 Nov-Dec;12(11-12):275-83 - PubMed
  39. J Clin Endocrinol Metab. 2005 Aug;90(8):4549-54 - PubMed
  40. Cell. 1999 Jun 25;97(7):889-901 - PubMed
  41. Atherosclerosis. 2002 Apr;161(2):365-74 - PubMed
  42. J Lipid Res. 2009 Apr;50 Suppl:S335-9 - PubMed
  43. Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1038-46 - PubMed
  44. Atherosclerosis. 2007 Aug;193(2):328-34 - PubMed
  45. Int J Angiol. 2016 Jun;25(2):110-6 - PubMed
  46. Diabetologia. 2007 Sep;50(9):1819-1825 - PubMed
  47. Ann Vasc Dis. 2018 Sep 25;11(3):253-258 - PubMed
  48. Obes Surg. 2007 Nov;17(11):1464-74 - PubMed
  49. J Lipid Res. 2000 Oct;41(10):1695-9 - PubMed
  50. Rev Cardiovasc Med. 2019 Dec 30;20(4):201-208 - PubMed
  51. Molecules. 2020 Apr 09;25(7): - PubMed
  52. Int Arch Allergy Appl Immunol. 1989;88(1-2):157-60 - PubMed
  53. J Clin Invest. 1994 Mar;93(3):1172-8 - PubMed
  54. Pathog Dis. 2013 Oct;69(1):1-6 - PubMed
  55. Curr Cardiol Rep. 2013 Sep;15(9):400 - PubMed
  56. Eur J Vasc Endovasc Surg. 2011 Mar;41(3):429-35 - PubMed
  57. Biochem Pharmacol. 1982 Jun 1;31(11):2031-7 - PubMed
  58. Int J Angiol. 2012 Mar;21(1):7-18 - PubMed
  59. Atherosclerosis. 1998 Nov;141(1):1-15 - PubMed
  60. J Atheroscler Thromb. 2009 Aug;16(4):339-45 - PubMed
  61. Am J Cardiol. 2000 Mar 15;85(6):777-9, A9 - PubMed
  62. Circulation. 1996 Nov 15;94(10):2369-72 - PubMed
  63. JAMA. 1979 May 11;241(19):2035-8 - PubMed
  64. Am Fam Physician. 2010 Feb 1;81(3):289-96 - PubMed
  65. Front Cardiovasc Med. 2021 Jan 26;8:633300 - PubMed
  66. Ann N Y Acad Sci. 1987;498:186-99 - PubMed
  67. Amino Acids. 2003 Dec;25(3-4):283-92 - PubMed
  68. Prostaglandins Leukot Essent Fatty Acids. 2000 Oct;63(4):177-86 - PubMed
  69. J Lipid Res. 2013 Nov;54(11):3052-61 - PubMed
  70. J Cardiovasc Pharmacol Ther. 2009 Mar;14(1):38-48 - PubMed
  71. Mol Immunol. 1985 Feb;22(2):101-6 - PubMed
  72. Circulation. 2003 Feb 25;107(7):947-53 - PubMed
  73. Drug News Perspect. 2000 Mar;13(2):99-104 - PubMed
  74. Mol Cell Biochem. 1992 Apr;111(1-2):103-8 - PubMed
  75. Circulation. 2019 Sep 10;140(11):e563-e595 - PubMed
  76. Diabetes Care. 2008 Feb;31 Suppl 2:S185-9 - PubMed
  77. Hypertension. 2000 Jul;36(1):137-41 - PubMed
  78. Nutrition. 2013 Jul-Aug;29(7-8):977-81 - PubMed
  79. Int J Angiol. 2015 Jun;24(2):75-80 - PubMed
  80. Curr Opin Lipidol. 2001 Aug;12(4):411-8 - PubMed
  81. Am J Hypertens. 2007 Mar;20(3):242-7 - PubMed
  82. Int J Hypertens. 2019 May 2;2019:3159283 - PubMed
  83. Int J Mol Sci. 2011 Jan 13;12(1):334-52 - PubMed
  84. Indian J Clin Biochem. 2009 Oct;24(4):388-97 - PubMed
  85. Arch Med Sci. 2018 Aug;14(5):979-987 - PubMed
  86. Curr Pharm Des. 2017;23(6):937-943 - PubMed
  87. Am J Med. 2004 Mar 22;116 Suppl 6A:9S-16S - PubMed
  88. Mol Cell Biochem. 2000 Mar;206(1-2):141-9 - PubMed
  89. J Am Soc Nephrol. 2005 Aug;16(8):2363-72 - PubMed
  90. Eur Heart J. 2017 Nov 14;38(43):3195-3201 - PubMed
  91. Int J Angiol. 2020 Sep;29(3):156-167 - PubMed
  92. JAMA. 1998 Jan 14;279(2):119-24 - PubMed
  93. Front Physiol. 2017 Aug 23;8:600 - PubMed
  94. J Atheroscler Thromb. 2018 Jan 1;25(1):27-39 - PubMed
  95. Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41 - PubMed
  96. J Am Coll Cardiol. 2004 May 19;43(10):1731-7 - PubMed
  97. Int Arch Allergy Appl Immunol. 1989;88(1-2):88-100 - PubMed
  98. Circulation. 2004 Mar 2;109(8):1022-8 - PubMed
  99. Circulation. 2001 Mar 6;103(9):1194-7 - PubMed
  100. Arterioscler Thromb Vasc Biol. 2000 May;20(5):1182-4 - PubMed
  101. BMJ. 1997 May 17;314(7092):1456-7 - PubMed
  102. J Nutr. 2003 Nov;133(11):3588-91 - PubMed
  103. Am Heart J. 1993 Apr;125(4):958-73 - PubMed
  104. Antioxid Redox Signal. 2011 Sep 15;15(6):1607-38 - PubMed
  105. J Am Diet Assoc. 2010 Jun;110(6):911-16.e12 - PubMed
  106. Drug Discov Today Ther Strateg. 2008 Mar;5(1):5-13 - PubMed
  107. Int Angiol. 1999 Dec;18(4):331-4 - PubMed
  108. Arterioscler Thromb Vasc Biol. 1995 Nov;15(11):1987-94 - PubMed
  109. Clin Cardiol. 2010 Nov;33(11):678-85 - PubMed
  110. Eur J Clin Nutr. 2012 Aug;66(8):872-7 - PubMed
  111. JAMA. 1992 Feb 12;267(6):811-5 - PubMed
  112. J Cardiovasc Pharmacol. 2009 Nov;54(5):369-77 - PubMed
  113. Circulation. 2001 May 29;103(21):2531-4 - PubMed
  114. J Res Med Sci. 2014 Apr;19(4):358-67 - PubMed
  115. J Clin Invest. 1993 Jun;91(6):2546-51 - PubMed
  116. Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2910-3 - PubMed
  117. Angiology. 1975 Jan;26(1 Pt. 1):1-14 - PubMed
  118. J Cardiovasc Pharmacol Ther. 2004 Sep;9(3):203-9 - PubMed
  119. Am J Cardiol. 2002 May 1;89(9):1117-9 - PubMed
  120. Circulation. 2000 Oct 31;102(18):2165-8 - PubMed
  121. Eur J Appl Physiol Occup Physiol. 1992;65(1):88-93 - PubMed
  122. Clin Chem Lab Med. 2001 Sep;39(9):822-6 - PubMed
  123. Int J Biol Macromol. 2017 Feb;95:121-125 - PubMed
  124. Eur J Clin Nutr. 2015 Aug;69(8):867-73 - PubMed
  125. Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1536-42 - PubMed
  126. Lipids Health Dis. 2008 Sep 01;7:32 - PubMed
  127. Curr Atheroscler Rep. 2006 Mar;8(2):100-6 - PubMed
  128. N Engl J Med. 1989 Apr 6;320(14):915-24 - PubMed
  129. J Mol Cell Cardiol. 2008 Jan;44(1):170-9 - PubMed
  130. Circulation. 2002 Feb 19;105(7):816-22 - PubMed
  131. Circ Res. 2012 Aug 17;111(5):585-98 - PubMed
  132. Eur Heart J. 2020 Jan 1;41(1):111-188 - PubMed
  133. Int J Angiol. 2017 Mar;26(1):1-11 - PubMed
  134. Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2840-7 - PubMed
  135. Int J Vasc Med. 2012;2012:862504 - PubMed
  136. Circulation. 2004 May 4;109(17):2116-22 - PubMed
  137. J Int Med Res. 2018 Mar;46(3):965-974 - PubMed
  138. Cytokine. 1992 Sep;4(5):361-8 - PubMed
  139. Biochim Biophys Acta. 1984 Apr 16;803(4):271-7 - PubMed
  140. Mol Cell Biochem. 2000 Jun;209(1-2):89-96 - PubMed
  141. Biosci Biotechnol Biochem. 1999 Nov;63(11):2011-3 - PubMed
  142. J Agric Food Chem. 2010 Oct 27;58(20):11119-29 - PubMed
  143. J Biol Chem. 1992 Feb 25;267(6):4143-51 - PubMed
  144. Circulation. 2000 Jun 27;101(25):2889-95 - PubMed
  145. Ann Epidemiol. 1999 Feb;9(2):121-6 - PubMed
  146. Int J Angiol. 2014 Mar;23(1):11-6 - PubMed
  147. J Cardiovasc Pharmacol Ther. 1997 Oct;2(4):309-320 - PubMed
  148. Int J Obes (Lond). 2021 Feb;45(2):331-336 - PubMed
  149. Circulation. 2006 Feb 14;113(6):898-918 - PubMed
  150. Circulation. 2005 Aug 2;112(5):651-7 - PubMed
  151. Cardiovasc Diabetol. 2002 Apr 08;1:1 - PubMed
  152. Circulation. 1999 Mar 16;99(10):1355-62 - PubMed
  153. Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1542-8 - PubMed
  154. Arch Med Res. 2015 Jul;46(5):339-50 - PubMed
  155. J Am Soc Nephrol. 2002 Jan;13(1):86-95 - PubMed
  156. Pediatr Res. 2002 Sep;52(3):454-8 - PubMed
  157. Nat Rev Cardiol. 2014 May;11(5):276-89 - PubMed
  158. J Hypertens. 2005 Sep;23(9):1725-9 - PubMed
  159. Free Radic Biol Med. 2009 Jan 1;46(1):70-7 - PubMed
  160. Diabetes Care. 2008 Feb;31 Suppl 2:S181-4 - PubMed
  161. BBA Clin. 2017 Aug 19;8:66-77 - PubMed

Publication Types