Int J Angiol. 2021 Aug 25;30(3):177-186. doi: 10.1055/s-0041-1731273. eCollection 2021 Sep.
Current Status of Primary, Secondary, and Tertiary Prevention of Coronary Artery Disease.
The International journal of angiology : official publication of the International College of Angiology, Inc
Kailash Prasad
Affiliations
Affiliations
- Department of Physiology (APP), College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
PMID: 34776817
PMCID: PMC8580611 DOI: 10.1055/s-0041-1731273
Abstract
Fifty percent of all death from cardiovascular diseases is due to coronary artery disease (CAD). This is avoidable if early identification is made. Preventive health care has a major role in the fight against CAD. Atherosclerosis and atherosclerotic plaque rupture are involved in the development of CAD. Modifiable risk factors for CAD are dyslipidemia, diabetes, hypertension, cigarette smoking, obesity, chronic renal disease, chronic infection, high C-reactive protein, and hyperhomocysteinemia. CAD can be prevented by modification of risk factors. This paper defines the primary, secondary, and tertiary prevention of CAD. It discusses the mechanism of risk factor-induced atherosclerosis. This paper describes the CAD risk score and its use in the selection of individuals for primary prevention of CAD. Guidelines for primary, secondary, and tertiary prevention of CAD have been described. Modification of risk factors and use of guidelines for prevention of CAD would prevent, regress, and slow down the progression of CAD, improve the quality of life of patient, and reduce the health care cost.
International College of Angiology. This article is published by Thieme.
Keywords: atherosclerosis; coronary artery disease; guidelines for prevention; modifiable risk factors of CAD; primary prevention; quality of life; secondary prevention; tertiary prevention
Conflict of interest statement
Conflict of Interest None declared.
References
- Cardiovasc Drug Rev. 2006 Spring;24(1):33-50 - PubMed
- Angiology. 2015 Sep;66(8):753-8 - PubMed
- Int J Angiol. 2018 Mar;27(1):1-12 - PubMed
- Hypertension. 2017 Aug;70(2):293-299 - PubMed
- J Biol Chem. 1989 Apr 15;264(11):6325-33 - PubMed
- Atherosclerosis. 2010 Mar;209(1):173-7 - PubMed
- Am J Clin Nutr. 2001 Sep;74(3):402-8 - PubMed
- BMJ. 2013 Jan 18;346:f10 - PubMed
- J Chronic Dis. 1974 Mar;27(3):103-14 - PubMed
- Chin J Physiol. 2003 Sep 30;46(3):129-36 - PubMed
- Circ Res. 1999 Mar 19;84(5):489-97 - PubMed
- Annu Rev Cell Biol. 1994;10:405-55 - PubMed
- J Immunol. 1981 Sep;127(3):1250-5 - PubMed
- Am J Cardiol. 1995 Jan 15;75(2):132-6 - PubMed
- Circulation. 1996 Apr 1;93(7):1346-53 - PubMed
- Lipids. 1991 Dec;26(12):1071-5 - PubMed
- J Int Med Res. 2007 Jul-Aug;35(4):482-9 - PubMed
- Circulation. 2011 Nov 29;124(22):2458-73 - PubMed
- Pharmacol Biochem Behav. 2011 Oct;99(4):659-64 - PubMed
- J Cardiovasc Pharmacol Ther. 2007 Dec;12(4):304-13 - PubMed
- Int J Mol Sci. 2014 Dec 26;16(1):378-400 - PubMed
- PLoS One. 2015 Mar 17;10(3):e0121971 - PubMed
- Oxid Med Cell Longev. 2011;2011:194586 - PubMed
- BMJ. 1989 Mar 25;298(6676):784-8 - PubMed
- Int J Exp Pathol. 1991 Feb;72(1):1-7 - PubMed
- Vasc Health Risk Manag. 2016 May 06;12:171-83 - PubMed
- Atherosclerosis. 2001 Jul;157(1):23-9 - PubMed
- Prostaglandins. 1987 Jun;33(6):931-9 - PubMed
- Clin Endocrinol Metab. 1976 Jul;5(2):367-75 - PubMed
- Circ Res. 2006 Jun 9;98(11):1352-64 - PubMed
- Arterioscler Thromb Vasc Biol. 1997 Oct;17(10):2167-76 - PubMed
- Atherosclerosis. 2012 Apr;221(2):496-502 - PubMed
- Microb Pathog. 1996 Sep;21(3):215-21 - PubMed
- Curr Opin Lipidol. 2011 Aug;22(4):254-61 - PubMed
- Clin Sci (Lond). 1995 Apr;88(4):485-9 - PubMed
- Biochem Biophys Res Commun. 2004 Jun 4;318(3):680-3 - PubMed
- Nat Rev Nephrol. 2011 Jan;7(1):45-54 - PubMed
- Mol Med. 2006 Nov-Dec;12(11-12):275-83 - PubMed
- J Clin Endocrinol Metab. 2005 Aug;90(8):4549-54 - PubMed
- Cell. 1999 Jun 25;97(7):889-901 - PubMed
- Atherosclerosis. 2002 Apr;161(2):365-74 - PubMed
- J Lipid Res. 2009 Apr;50 Suppl:S335-9 - PubMed
- Am J Physiol Endocrinol Metab. 2008 Nov;295(5):E1038-46 - PubMed
- Atherosclerosis. 2007 Aug;193(2):328-34 - PubMed
- Int J Angiol. 2016 Jun;25(2):110-6 - PubMed
- Diabetologia. 2007 Sep;50(9):1819-1825 - PubMed
- Ann Vasc Dis. 2018 Sep 25;11(3):253-258 - PubMed
- Obes Surg. 2007 Nov;17(11):1464-74 - PubMed
- J Lipid Res. 2000 Oct;41(10):1695-9 - PubMed
- Rev Cardiovasc Med. 2019 Dec 30;20(4):201-208 - PubMed
- Molecules. 2020 Apr 09;25(7): - PubMed
- Int Arch Allergy Appl Immunol. 1989;88(1-2):157-60 - PubMed
- J Clin Invest. 1994 Mar;93(3):1172-8 - PubMed
- Pathog Dis. 2013 Oct;69(1):1-6 - PubMed
- Curr Cardiol Rep. 2013 Sep;15(9):400 - PubMed
- Eur J Vasc Endovasc Surg. 2011 Mar;41(3):429-35 - PubMed
- Biochem Pharmacol. 1982 Jun 1;31(11):2031-7 - PubMed
- Int J Angiol. 2012 Mar;21(1):7-18 - PubMed
- Atherosclerosis. 1998 Nov;141(1):1-15 - PubMed
- J Atheroscler Thromb. 2009 Aug;16(4):339-45 - PubMed
- Am J Cardiol. 2000 Mar 15;85(6):777-9, A9 - PubMed
- Circulation. 1996 Nov 15;94(10):2369-72 - PubMed
- JAMA. 1979 May 11;241(19):2035-8 - PubMed
- Am Fam Physician. 2010 Feb 1;81(3):289-96 - PubMed
- Front Cardiovasc Med. 2021 Jan 26;8:633300 - PubMed
- Ann N Y Acad Sci. 1987;498:186-99 - PubMed
- Amino Acids. 2003 Dec;25(3-4):283-92 - PubMed
- Prostaglandins Leukot Essent Fatty Acids. 2000 Oct;63(4):177-86 - PubMed
- J Lipid Res. 2013 Nov;54(11):3052-61 - PubMed
- J Cardiovasc Pharmacol Ther. 2009 Mar;14(1):38-48 - PubMed
- Mol Immunol. 1985 Feb;22(2):101-6 - PubMed
- Circulation. 2003 Feb 25;107(7):947-53 - PubMed
- Drug News Perspect. 2000 Mar;13(2):99-104 - PubMed
- Mol Cell Biochem. 1992 Apr;111(1-2):103-8 - PubMed
- Circulation. 2019 Sep 10;140(11):e563-e595 - PubMed
- Diabetes Care. 2008 Feb;31 Suppl 2:S185-9 - PubMed
- Hypertension. 2000 Jul;36(1):137-41 - PubMed
- Nutrition. 2013 Jul-Aug;29(7-8):977-81 - PubMed
- Int J Angiol. 2015 Jun;24(2):75-80 - PubMed
- Curr Opin Lipidol. 2001 Aug;12(4):411-8 - PubMed
- Am J Hypertens. 2007 Mar;20(3):242-7 - PubMed
- Int J Hypertens. 2019 May 2;2019:3159283 - PubMed
- Int J Mol Sci. 2011 Jan 13;12(1):334-52 - PubMed
- Indian J Clin Biochem. 2009 Oct;24(4):388-97 - PubMed
- Arch Med Sci. 2018 Aug;14(5):979-987 - PubMed
- Curr Pharm Des. 2017;23(6):937-943 - PubMed
- Am J Med. 2004 Mar 22;116 Suppl 6A:9S-16S - PubMed
- Mol Cell Biochem. 2000 Mar;206(1-2):141-9 - PubMed
- J Am Soc Nephrol. 2005 Aug;16(8):2363-72 - PubMed
- Eur Heart J. 2017 Nov 14;38(43):3195-3201 - PubMed
- Int J Angiol. 2020 Sep;29(3):156-167 - PubMed
- JAMA. 1998 Jan 14;279(2):119-24 - PubMed
- Front Physiol. 2017 Aug 23;8:600 - PubMed
- J Atheroscler Thromb. 2018 Jan 1;25(1):27-39 - PubMed
- Am J Physiol Cell Physiol. 2001 Apr;280(4):C719-41 - PubMed
- J Am Coll Cardiol. 2004 May 19;43(10):1731-7 - PubMed
- Int Arch Allergy Appl Immunol. 1989;88(1-2):88-100 - PubMed
- Circulation. 2004 Mar 2;109(8):1022-8 - PubMed
- Circulation. 2001 Mar 6;103(9):1194-7 - PubMed
- Arterioscler Thromb Vasc Biol. 2000 May;20(5):1182-4 - PubMed
- BMJ. 1997 May 17;314(7092):1456-7 - PubMed
- J Nutr. 2003 Nov;133(11):3588-91 - PubMed
- Am Heart J. 1993 Apr;125(4):958-73 - PubMed
- Antioxid Redox Signal. 2011 Sep 15;15(6):1607-38 - PubMed
- J Am Diet Assoc. 2010 Jun;110(6):911-16.e12 - PubMed
- Drug Discov Today Ther Strateg. 2008 Mar;5(1):5-13 - PubMed
- Int Angiol. 1999 Dec;18(4):331-4 - PubMed
- Arterioscler Thromb Vasc Biol. 1995 Nov;15(11):1987-94 - PubMed
- Clin Cardiol. 2010 Nov;33(11):678-85 - PubMed
- Eur J Clin Nutr. 2012 Aug;66(8):872-7 - PubMed
- JAMA. 1992 Feb 12;267(6):811-5 - PubMed
- J Cardiovasc Pharmacol. 2009 Nov;54(5):369-77 - PubMed
- Circulation. 2001 May 29;103(21):2531-4 - PubMed
- J Res Med Sci. 2014 Apr;19(4):358-67 - PubMed
- J Clin Invest. 1993 Jun;91(6):2546-51 - PubMed
- Arterioscler Thromb Vasc Biol. 1997 Nov;17(11):2910-3 - PubMed
- Angiology. 1975 Jan;26(1 Pt. 1):1-14 - PubMed
- J Cardiovasc Pharmacol Ther. 2004 Sep;9(3):203-9 - PubMed
- Am J Cardiol. 2002 May 1;89(9):1117-9 - PubMed
- Circulation. 2000 Oct 31;102(18):2165-8 - PubMed
- Eur J Appl Physiol Occup Physiol. 1992;65(1):88-93 - PubMed
- Clin Chem Lab Med. 2001 Sep;39(9):822-6 - PubMed
- Int J Biol Macromol. 2017 Feb;95:121-125 - PubMed
- Eur J Clin Nutr. 2015 Aug;69(8):867-73 - PubMed
- Arterioscler Thromb Vasc Biol. 2000 Jun;20(6):1536-42 - PubMed
- Lipids Health Dis. 2008 Sep 01;7:32 - PubMed
- Curr Atheroscler Rep. 2006 Mar;8(2):100-6 - PubMed
- N Engl J Med. 1989 Apr 6;320(14):915-24 - PubMed
- J Mol Cell Cardiol. 2008 Jan;44(1):170-9 - PubMed
- Circulation. 2002 Feb 19;105(7):816-22 - PubMed
- Circ Res. 2012 Aug 17;111(5):585-98 - PubMed
- Eur Heart J. 2020 Jan 1;41(1):111-188 - PubMed
- Int J Angiol. 2017 Mar;26(1):1-11 - PubMed
- Am J Physiol Heart Circ Physiol. 2001 Jun;280(6):H2840-7 - PubMed
- Int J Vasc Med. 2012;2012:862504 - PubMed
- Circulation. 2004 May 4;109(17):2116-22 - PubMed
- J Int Med Res. 2018 Mar;46(3):965-974 - PubMed
- Cytokine. 1992 Sep;4(5):361-8 - PubMed
- Biochim Biophys Acta. 1984 Apr 16;803(4):271-7 - PubMed
- Mol Cell Biochem. 2000 Jun;209(1-2):89-96 - PubMed
- Biosci Biotechnol Biochem. 1999 Nov;63(11):2011-3 - PubMed
- J Agric Food Chem. 2010 Oct 27;58(20):11119-29 - PubMed
- J Biol Chem. 1992 Feb 25;267(6):4143-51 - PubMed
- Circulation. 2000 Jun 27;101(25):2889-95 - PubMed
- Ann Epidemiol. 1999 Feb;9(2):121-6 - PubMed
- Int J Angiol. 2014 Mar;23(1):11-6 - PubMed
- J Cardiovasc Pharmacol Ther. 1997 Oct;2(4):309-320 - PubMed
- Int J Obes (Lond). 2021 Feb;45(2):331-336 - PubMed
- Circulation. 2006 Feb 14;113(6):898-918 - PubMed
- Circulation. 2005 Aug 2;112(5):651-7 - PubMed
- Cardiovasc Diabetol. 2002 Apr 08;1:1 - PubMed
- Circulation. 1999 Mar 16;99(10):1355-62 - PubMed
- Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1542-8 - PubMed
- Arch Med Res. 2015 Jul;46(5):339-50 - PubMed
- J Am Soc Nephrol. 2002 Jan;13(1):86-95 - PubMed
- Pediatr Res. 2002 Sep;52(3):454-8 - PubMed
- Nat Rev Cardiol. 2014 May;11(5):276-89 - PubMed
- J Hypertens. 2005 Sep;23(9):1725-9 - PubMed
- Free Radic Biol Med. 2009 Jan 1;46(1):70-7 - PubMed
- Diabetes Care. 2008 Feb;31 Suppl 2:S181-4 - PubMed
- BBA Clin. 2017 Aug 19;8:66-77 - PubMed
Publication Types