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Lertjuthaporn S, Keawvichit R, Polsrila K, et al. Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection. Pathogens. 2021;10(11)doi: 10.3390/pathogens10111458.
Lertjuthaporn, S., Keawvichit, R., Polsrila, K., Sukapirom, K., Chuansumrit, A., Chokephaibulkit, K., Ansari, A. A., Khowawisetsut, L., & Pattanapanyasat, K. (2021). Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection. Pathogens (Basel, Switzerland), 10(11), . https://doi.org/10.3390/pathogens10111458
Lertjuthaporn, Sakaorat, et al. "Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection." Pathogens (Basel, Switzerland) vol. 10,11 (2021). doi: https://doi.org/10.3390/pathogens10111458
Lertjuthaporn S, Keawvichit R, Polsrila K, Sukapirom K, Chuansumrit A, Chokephaibulkit K, Ansari AA, Khowawisetsut L, Pattanapanyasat K. Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection. Pathogens. 2021 Nov 10;10(11). doi: 10.3390/pathogens10111458. PMID: 34832614; PMCID: PMC8625762.
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Pathogens. 2021 Nov 10;10(11). doi: 10.3390/pathogens10111458.

Kinetic Changes of Peripheral Blood Monocyte Subsets and Expression of Co-Stimulatory Molecules during Acute Dengue Virus Infection.

Pathogens (Basel, Switzerland)

Sakaorat Lertjuthaporn, Rassamon Keawvichit, Korakot Polsrila, Kasama Sukapirom, Ampaiwan Chuansumrit, Kulkanya Chokephaibulkit, Aftab A Ansari, Ladawan Khowawisetsut, Kovit Pattanapanyasat

Affiliations

  1. Center for Research and Innovation, Faculty of Medical Technology, Mahidol University, Nakhon Pathom 73170, Thailand.
  2. Department of Clinical Pathology, Faculty of Medicine Vajira Hospital, Navamindradhiraj University, Bangkok 10300, Thailand.
  3. Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  4. Center of Excellence for Microparticle and Exosome in Diseases, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  5. Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.
  6. Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  7. Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
  8. Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.

PMID: 34832614 PMCID: PMC8625762 DOI: 10.3390/pathogens10111458

Abstract

Monocytes, one of the main target cells for dengue virus (DENV) infection, contribute to the resolution of viremia and to pathogenesis. We performed a longitudinal study by a detailed phenotypic comparison of classical (CD14++CD16-, non-classical (CD14+CD16++) and intermediate (CD14++CD16+) monocyte subsets in blood samples from dengue fever (DF) to the severe dengue hemorrhagic fever (DHF) and healthy individuals. Various costimulatory molecules of CD40, CD80, CD86 and inducible costimulatory ligand (ICOSL) expressed on these three monocyte subsets were also analyzed. DENV-infected patients showed an increase in the frequency of intermediate monocytes and a decrease in the classical monocytes when compared to healthy individuals. Although these differences did not correlate with disease severity, changes during the early phase of infection gradually returned to normal in the defervescence phase. Moreover, decreased frequency of classical monocytes was associated with a significant up-regulation of co-stimulatory molecules CD40, CD86 and ICOSL. Kinetics of these co-stimulatory molecule-expressing classical monocytes showed different patterns throughout the sampling times of acute DENV infection. Different distribution of monocyte subsets and their co-stimulatory molecules in the peripheral blood during acute infection might exacerbate immune responses like cytokine storms and ADE, and future studies on intracellular molecular pathways utilized by these monocyte linages are warranted.

Keywords: co-stimulation; dengue infection; flow cytometry; monocyte

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