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Benslimane FM, Al Khatib HA, Al-Jamal O, et al. One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar. Front Cell Infect Microbiol. 2021;11:768883doi: 10.3389/fcimb.2021.768883.
Benslimane, F. M., Al Khatib, H. A., Al-Jamal, O., Albatesh, D., Boughattas, S., Ahmed, A. A., Bensaad, M., Younuskunju, S., Mohamoud, Y. A., Al Badr, M., Mohamed, A. A., El-Kahlout, R. A., Al-Hamad, T., Elgakhlab, D., Al-Kuwari, F. H., Saad, C., Jeremijenko, A., Al-Khal, A., Al-Maslamani, M. A., Bertollini, R., Al-Kuwari, E. A., Al-Romaihi, H. E., Al-Marri, S., Al-Thani, M., Badji, R. M., Mbarek, H., Al-Sarraj, Y., Malek, J. A., Ismail, S. I., Abu-Raddad, L. J., Coyle, P. V., Thani, A. A. A., & Yassine, H. M. (2021). One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar. Frontiers in cellular and infection microbiology, 11768883. https://doi.org/10.3389/fcimb.2021.768883
Benslimane, Fatiha M, et al. "One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar." Frontiers in cellular and infection microbiology vol. 11 (2021): 768883. doi: https://doi.org/10.3389/fcimb.2021.768883
Benslimane FM, Al Khatib HA, Al-Jamal O, Albatesh D, Boughattas S, Ahmed AA, Bensaad M, Younuskunju S, Mohamoud YA, Al Badr M, Mohamed AA, El-Kahlout RA, Al-Hamad T, Elgakhlab D, Al-Kuwari FH, Saad C, Jeremijenko A, Al-Khal A, Al-Maslamani MA, Bertollini R, Al-Kuwari EA, Al-Romaihi HE, Al-Marri S, Al-Thani M, Badji RM, Mbarek H, Al-Sarraj Y, Malek JA, Ismail SI, Abu-Raddad LJ, Coyle PV, Thani AAA, Yassine HM. One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar. Front Cell Infect Microbiol. 2021 Nov 17;11:768883. doi: 10.3389/fcimb.2021.768883. eCollection 2021. PMID: 34869069; PMCID: PMC8637114.
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Front Cell Infect Microbiol. 2021 Nov 17;11:768883. doi: 10.3389/fcimb.2021.768883. eCollection 2021.

One Year of SARS-CoV-2: Genomic Characterization of COVID-19 Outbreak in Qatar.

Frontiers in cellular and infection microbiology

Fatiha M Benslimane, Hebah A Al Khatib, Ola Al-Jamal, Dana Albatesh, Sonia Boughattas, Ayeda A Ahmed, Meryem Bensaad, Shameem Younuskunju, Yasmin A Mohamoud, Mashael Al Badr, Abdalla A Mohamed, Reham A El-Kahlout, Tasneem Al-Hamad, Dina Elgakhlab, Fatima H Al-Kuwari, Chadi Saad, Andrew Jeremijenko, Abdullatif Al-Khal, Muna A Al-Maslamani, Roberto Bertollini, Einas A Al-Kuwari, Hamad E Al-Romaihi, Salih Al-Marri, Mohammed Al-Thani, Radja M Badji, Hamdi Mbarek, Yasser Al-Sarraj, Joel A Malek, Said I Ismail, Laith J Abu-Raddad, Peter V Coyle, Asmaa A Al Thani, Hadi M Yassine

Affiliations

  1. Biomedical Research Center, Qatar University, Doha, Qatar.
  2. Genomics Laboratory, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
  3. National Reference Laboratory Ministry of Public Health, Doha, Qatar.
  4. Hamad Medical Corporation, Doha, Qatar.
  5. Qatar Biobank, Doha, Qatar.
  6. Qatar Genome Program, Qatar Foundation Research, Development and Innovation, Qatar Foundation, Doha, Qatar.
  7. Communicable Diseases Center, Hamad Medical Corporation, Doha, Qatar.
  8. Ministry of Public Health, Doha, Qatar.
  9. Department of Genetic Medicine, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
  10. Infectious Disease Epidemiology Group, Weill Cornell Medicine-Qatar, Cornell University, Doha, Qatar.
  11. Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York, NY, United States.
  12. World Health Organization Collaborating Centre for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis, Weill Cornell Medicine-Qatar, Doha, Qatar.
  13. Department of Biomedical Science, College of Health Sciences, QU Health, Qatar University, Doha, Qatar.

PMID: 34869069 PMCID: PMC8637114 DOI: 10.3389/fcimb.2021.768883

Abstract

Qatar, a country with a strong health system and a diverse population consisting mainly of expatriate residents, has experienced two large waves of COVID-19 outbreak. In this study, we report on 2634 SARS-CoV-2 whole-genome sequences from infected patients in Qatar between March-2020 and March-2021, representing 1.5% of all positive cases in this period. Despite the restrictions on international travel, the viruses sampled from the populace of Qatar mirrored nearly the entire global population's genomic diversity with nine predominant viral lineages that were sustained by local transmission chains and the emergence of mutations that are likely to have originated in Qatar. We reported an increased number of mutations and deletions in B.1.1.7 and B.1.351 lineages in a short period. These findings raise the imperative need to continue the ongoing genomic surveillance that has been an integral part of the national response to monitor the SARS-CoV-2 profile and re-emergence in Qatar.

Copyright © 2021 Benslimane, Al Khatib, Al-Jamal, Albatesh, Boughattas, Ahmed, Bensaad, Younuskunju, Mohamoud, Al Badr, Mohamed, El-Kahlout, Al-Hamad, Elgakhlab, Al-Kuwari, Saad, Jeremijenko, Al-Khal, Al-Maslamani, Bertollini, Al-Kuwari, Al-Romaihi, Al-Marri, Al-Thani, Badji, Mbarek, Al-Sarraj, Malek, Ismail, Abu-Raddad, Coyle, Thani and Yassine.

Keywords: COVID19; N481K; Qatar; SARS-CoV-2; variant analysis

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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