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Fralish Z, Lotz EM, Chavez T, et al. Neuromuscular Development and Disease: Learning From . Front Cell Dev Biol. 2021;9:764732doi: 10.3389/fcell.2021.764732.
Fralish, Z., Lotz, E. M., Chavez, T., Khodabukus, A., & Bursac, N. (2021). Neuromuscular Development and Disease: Learning From . Frontiers in cell and developmental biology, 9764732. https://doi.org/10.3389/fcell.2021.764732
Fralish, Zachary, et al. "Neuromuscular Development and Disease: Learning From ." Frontiers in cell and developmental biology vol. 9 (2021): 764732. doi: https://doi.org/10.3389/fcell.2021.764732
Fralish Z, Lotz EM, Chavez T, Khodabukus A, Bursac N. Neuromuscular Development and Disease: Learning From . Front Cell Dev Biol. 2021 Oct 27;9:764732. doi: 10.3389/fcell.2021.764732. eCollection 2021. PMID: 34778273; PMCID: PMC8579029.
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Front Cell Dev Biol. 2021 Oct 27;9:764732. doi: 10.3389/fcell.2021.764732. eCollection 2021.

Neuromuscular Development and Disease: Learning From .

Frontiers in cell and developmental biology

Zachary Fralish, Ethan M Lotz, Taylor Chavez, Alastair Khodabukus, Nenad Bursac

Affiliations

  1. Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, United States.

PMID: 34778273 PMCID: PMC8579029 DOI: 10.3389/fcell.2021.764732

Abstract

The neuromuscular junction (NMJ) is a specialized cholinergic synaptic interface between a motor neuron and a skeletal muscle fiber that translates presynaptic electrical impulses into motor function. NMJ formation and maintenance require tightly regulated signaling and cellular communication among motor neurons, myogenic cells, and Schwann cells. Neuromuscular diseases (NMDs) can result in loss of NMJ function and motor input leading to paralysis or even death. Although small animal models have been instrumental in advancing our understanding of the NMJ structure and function, the complexities of studying this multi-tissue system

Copyright © 2021 Fralish, Lotz, Chavez, Khodabukus and Bursac.

Keywords: disease modeling; drug development; human skeletal muscle; induced pluripotent stem cells; muscular dystrophy; neuromuscular junction; organ on a chip; tissue engineering

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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