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Case DR, Gonzalez R, Zubieta J, et al. Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes. ACS Omega. 2021;6(44):29713-29723doi: 10.1021/acsomega.1c04104.
Case, D. R., Gonzalez, R., Zubieta, J., & Doyle, R. P. (2021). Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes. ACS omega, 6(44), 29713-29723. https://doi.org/10.1021/acsomega.1c04104
Case, Derek R, et al. "Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes." ACS omega vol. 6,44 (2021): 29713-29723. doi: https://doi.org/10.1021/acsomega.1c04104
Case DR, Gonzalez R, Zubieta J, Doyle RP. Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes. ACS Omega. 2021 Oct 28;6(44):29713-29723. doi: 10.1021/acsomega.1c04104. eCollection 2021 Nov 09. PMID: 34778643; PMCID: PMC8587132.
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ACS Omega. 2021 Oct 28;6(44):29713-29723. doi: 10.1021/acsomega.1c04104. eCollection 2021 Nov 09.

Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes.

ACS omega

Derek R Case, Ren Gonzalez, Jon Zubieta, Robert P Doyle

Affiliations

  1. Department of Chemistry, Syracuse University, 111 College Place, Syracuse, New York 13244, United States.
  2. Balchem Corporation, 52 Sunrise Park Road, New Hampton, New York 10958, United States.

PMID: 34778643 PMCID: PMC8587132 DOI: 10.1021/acsomega.1c04104

Abstract

Magnesium deficiency and/or deficit (hypomagnesemia, <0.75 mmol/L in the blood) has become a recognized problem in healthcare and clinical settings. Concomitantly, supplementation has become recognized as the primary means of mitigating such deficiencies. Common magnesium supplements typically suffer from shortcomings: rapid dissociation and subsequent laxation (magnesium salts: e.g., magnesium chloride), poor water solubility (magnesium oxides and hydroxides), poor characterizability (magnesium chelates), and are/or use of non-natural ligands. To this end, there is a need for the development of fully characterized, water-soluble, all-natural magnesium compounds. Herein, we discuss the synthesis, solution and solid-state characterization, aqueous solubility, and cellular uptake of magnesium complexes of maltol and ethylmaltol, ligands whose magnesium complexes have yet to be fully explored.

© 2021 The Authors. Published by American Chemical Society.

Conflict of interest statement

The authors declare the following competing financial interest(s): I sit on the scientific advisory board of Balchem, with whom this paper is a collaboration. No funding for this paper was received fr

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