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Viering T, Hoekstra PJ, Philipsen A, et al. Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence. Neuroimage. 2021;245:118729doi: 10.1016/j.neuroimage.2021.118729.
Viering, T., Hoekstra, P. J., Philipsen, A., Naaijen, J., Dietrich, A., Hartman, C. A., Franke, B., Buitelaar, J. K., Hildebrandt, A., Thiel, C. M., & Gießing, C. (2021). Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence. NeuroImage, 245118729. https://doi.org/10.1016/j.neuroimage.2021.118729
Viering, Tammo, et al. "Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence." NeuroImage vol. 245 (2021): 118729. doi: https://doi.org/10.1016/j.neuroimage.2021.118729
Viering T, Hoekstra PJ, Philipsen A, Naaijen J, Dietrich A, Hartman CA, Franke B, Buitelaar JK, Hildebrandt A, Thiel CM, Gießing C. Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence. Neuroimage. 2021 Nov 20;245:118729. doi: 10.1016/j.neuroimage.2021.118729. Epub 2021 Nov 20. PMID: 34813971.
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Neuroimage. 2021 Nov 20;245:118729. doi: 10.1016/j.neuroimage.2021.118729. Epub 2021 Nov 20.

Emotion dysregulation and integration of emotion-related brain networks affect intraindividual change in ADHD severity throughout late adolescence.

NeuroImage

Tammo Viering, Pieter J Hoekstra, Alexandra Philipsen, Jilly Naaijen, Andrea Dietrich, Catharina A Hartman, Barbara Franke, Jan K Buitelaar, Andrea Hildebrandt, Christiane M Thiel, Carsten Gießing

Affiliations

  1. Biological Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl-von-Ossietzky Universität Oldenburg, Postfach 2503, Oldenburg 26111, Germany; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, Netherlands. Electronic address: [email protected].
  2. University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, Netherlands.
  3. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
  4. Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, Netherlands; Radboud University, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands.
  5. Department of Psychiatry, University of Groningen, University Medical Center Groningen, Interdisciplinary Center Psychopathology and Emotion Regulation, Groningen, Netherlands.
  6. Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Human Genetics, Nijmegen, Netherlands; Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Psychiatry, Nijmegen, Netherlands.
  7. Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, Nijmegen, Netherlands; Radboud University, Donders Institute for Brain, Cognition and Behaviour, Centre for Cognitive Neuroimaging, Nijmegen, Netherlands; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, Netherlands.
  8. Psychological Methods and Statistics, Department of Psychology, School of Medicine and Health Sciences, Carl-von-Ossietzky Universität Oldenburg, Oldenburg, Germany.
  9. Biological Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl-von-Ossietzky Universität Oldenburg, Postfach 2503, Oldenburg 26111, Germany; Research Center Neurosensory Science, Carl-von-Ossietzky Universität Oldenburg, Oldenburg, Germany; Cluster of Excellence "Hearing4all", Carl von Ossietzky Universität Oldenburg, Oldenburg, Germany.
  10. Biological Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl-von-Ossietzky Universität Oldenburg, Postfach 2503, Oldenburg 26111, Germany.

PMID: 34813971 DOI: 10.1016/j.neuroimage.2021.118729

Abstract

The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the course are not well understood. A frequent problem in ADHD, associated with worse outcomes, is emotion dysregulation. We investigated whether emotion dysregulation and integration of emotion-related functional brain networks affect interindividual differences in ADHD severity change. ADHD severity and resting state neuroimaging data were measured in ADHD and unaffected individuals at two points during adolescence and young adulthood. Bivariate latent change score models were applied to investigate whether emotion dysregulation and network integration affect ADHD severity changes. Emotion dysregulation was gauged from questionnaire subscales for conduct problems, emotional problems and emotional lability. Better emotion regulation was associated with a better course of ADHD (104 participants, 44 females, age range: 12-27). Using graph analysis, we determined network integration of emotion-related functional brain networks. Network integration was measured by nodal efficiency, i.e., the average inverse path distance from one node to all other nodes. A pattern of low nodal efficiency of cortical regions associated with emotion processing and high nodal efficiency in subcortical areas and cortical areas involved in implicit emotion regulation predicted a better ADHD course. Larger nodal efficiency of the right orbitofrontal cortex was related to a better course of ADHD (99 participants, 42 females, age range: 10-29). We demonstrated that neural and behavioral covariates associated with emotion regulation affect the course of ADHD severity throughout adolescence and early adulthood beyond baseline effects of ADHD severity.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Attention deficit/hyperactivity disorder; Emotion dysregulation; Latent change score modeling; Nodal efficiency; Orbitofrontal cortex; Resting state fmri

Conflict of interest statement

Declaration of Competing Interests Jan K. Buitelaar has been in the past 3 years a consultant to / member of advisory board of / and/or speaker for Shire, Roche, Medice, and Servier. He is not an empl

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