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Gryp T, Faust K, Van Biesen W, et al. Gut Microbiome Profiling Uncovers a Lower Abundance of . J Pers Med. 2021;11(11)doi: 10.3390/jpm11111118.
Gryp, T., Faust, K., Van Biesen, W., Huys, G. R. B., Verbeke, F., Speeckaert, M., Raes, J., Vaneechoutte, M., Joossens, M., & Glorieux, G. (2021). Gut Microbiome Profiling Uncovers a Lower Abundance of . Journal of personalized medicine, 11(11), . https://doi.org/10.3390/jpm11111118
Gryp, Tessa, et al. "Gut Microbiome Profiling Uncovers a Lower Abundance of ." Journal of personalized medicine vol. 11,11 (2021). doi: https://doi.org/10.3390/jpm11111118
Gryp T, Faust K, Van Biesen W, Huys GRB, Verbeke F, Speeckaert M, Raes J, Vaneechoutte M, Joossens M, Glorieux G. Gut Microbiome Profiling Uncovers a Lower Abundance of . J Pers Med. 2021 Oct 29;11(11). doi: 10.3390/jpm11111118. PMID: 34834470; PMCID: PMC8621827.
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J Pers Med. 2021 Oct 29;11(11). doi: 10.3390/jpm11111118.

Gut Microbiome Profiling Uncovers a Lower Abundance of .

Journal of personalized medicine

Tessa Gryp, Karoline Faust, Wim Van Biesen, Geert R B Huys, Francis Verbeke, Marijn Speeckaert, Jeroen Raes, Mario Vaneechoutte, Marie Joossens, Griet Glorieux

Affiliations

  1. Department of Internal Medicine and Pediatrics, Nephrology Section, Ghent University Hospital, 9000 Ghent, Belgium.
  2. Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, 3000 Leuven, Belgium.
  3. Laboratory Bacteriology Research, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.
  4. Center for Microbiology, VIB, 3001 Leuven, Belgium.
  5. Laboratory of Microbiology, Department of Biochemistry and Microbiology, Ghent University, 9000 Ghent, Belgium.

PMID: 34834470 PMCID: PMC8621827 DOI: 10.3390/jpm11111118

Abstract

Chronic kidney disease (CKD) is characterized by the accumulation of uremic toxins which exert deleterious effects on various organ systems. Several of these uremic toxins originate from the bacterial metabolization of aromatic amino acids in the colon. This study assessed whether the gut microbial composition varies among patients in different stages of CKD. Uremic metabolites were quantified by UPLC/fluorescence detection and microbial profiling by 16S rRNA amplicon sequencing. Gut microbial profiles of CKD patients were compared among stages 1-2, stage 3 and stages 4-5. Although a substantial inter-individual difference in abundance of the top 15 genera was observed, no significant difference was observed between groups. Bristol stool scale (BSS) correlated negatively with

Keywords: chronic kidney disease; gut microbial composition; p-cresyl glucuronide; p-cresyl sulfate; uremic toxins

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