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Wikandari R, Manikharda, Baldermann S, et al. Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security. Bioengineered. 2021;12(2):11305-11330doi: 10.1080/21655979.2021.2003665.
Wikandari, R., Manikharda, Baldermann, S., Ningrum, A., & Taherzadeh, M. J. (2021). Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security. Bioengineered, 12(2), 11305-11330. https://doi.org/10.1080/21655979.2021.2003665
Wikandari, Rachma, et al. "Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security." Bioengineered vol. 12,2 (2021): 11305-11330. doi: https://doi.org/10.1080/21655979.2021.2003665
Wikandari R, Manikharda, Baldermann S, Ningrum A, Taherzadeh MJ. Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security. Bioengineered. 2021 Dec;12(2):11305-11330. doi: 10.1080/21655979.2021.2003665. PMID: 34779353.
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Bioengineered. 2021 Dec;12(2):11305-11330. doi: 10.1080/21655979.2021.2003665.

Application of cell culture technology and genetic engineering for production of future foods and crop improvement to strengthen food security.

Bioengineered

Rachma Wikandari, Manikharda, Susanne Baldermann, Andriati Ningrum, Mohammad J Taherzadeh

Affiliations

  1. Department of Food and Agricultural Product Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
  2. Faculty of Life Science, Food Nutrition and Health, Food Metabolome, Universitat Bayreuth, Kulmbach, 95326, Germany.
  3. Food4Future (F4F), Leibniz Institute of Vegetable and Ornamental Crops (IGZ), Theodor-Echtermeyer-Weg1, Grossbeeren, Germany.
  4. Swedish Centre for Resource Recovery, University of Borås, Borås, Sweden.

PMID: 34779353 DOI: 10.1080/21655979.2021.2003665

Abstract

The growing population and the climate changes put a pressure on food production globally, therefore a fundamental transformation of food production is required. One approach to accelerate food production is application of modern biotechnology such as cell culture, marker assisted selection, and genetic engineering. Cell culture technology reduces the usage of arable land, while marker-assisted selection increases the genetic gain of crop breeding and genetic engineering enable to introduce a desired traits to crop. The cell culture technology has resulted in development of cultured meat, fungal biomass food (mycoprotein), and bioactive compounds from plant cell culture. Except cultured meat which recently begin to penetrate the market, the other products have been in the market for years. The marker-assisted selection and genetic engineering have contributed significantly to increase the resiliency against emerging pests and abiotic stresses. This review addresses diverse techniques of cell culture technology as well as advanced genetic engineering technology CRISPR Cas-9 and its application for crop improvement. The pros and cons of different techniques as well as the challenges and future perspective of application of modern biotechnology for strengthening food security are also discussed.

Keywords: Agrobacterium transformation; CRISPR-Cas9; Cultured meat; genetic engineering; mycoprotein

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