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De Somma E, O'Mahony J, Brown RA, et al. Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child Neuropsychol. 2021;1-22doi: 10.1080/09297049.2021.2002289.
De Somma, E., O'Mahony, J., Brown, R. A., Brooks, B. L., Yeh, E. A., Cardenas de La Parra, A., Arnold, D., Collins, D. L., Maranzano, J., Narayanan, S., Marrie, R. A., Bar-Or, A., Banwell, B., & Till, C. (2021). Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence, 1-22. https://doi.org/10.1080/09297049.2021.2002289
De Somma, Elisea, et al. "Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study." Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence vol. (2021): 1-22. doi: https://doi.org/10.1080/09297049.2021.2002289
De Somma E, O'Mahony J, Brown RA, Brooks BL, Yeh EA, Cardenas de La Parra A, Arnold D, Collins DL, Maranzano J, Narayanan S, Marrie RA, Bar-Or A, Banwell B, Till C. Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study. Child Neuropsychol. 2021 Dec 06;1-22. doi: 10.1080/09297049.2021.2002289. Epub 2021 Dec 06. PMID: 34872458.
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Child Neuropsychol. 2021 Dec 06;1-22. doi: 10.1080/09297049.2021.2002289. Epub 2021 Dec 06.

Disrupted cognitive development following pediatric acquired demyelinating syndromes: a longitudinal study.

Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence

Elisea De Somma, Julia O'Mahony, Robert A Brown, Brian L Brooks, E Ann Yeh, Alonso Cardenas de La Parra, Douglas Arnold, D Louis Collins, Josefina Maranzano, Sridar Narayanan, Ruth Ann Marrie, Amit Bar-Or, Brenda Banwell, Christine Till

Affiliations

  1. Department of Psychology, York University, Toronto, Canada.
  2. Neurosciences and Mental Health, Hospital for Sick Children, Canada Hospital for Sick Children, Toronto, Canada.
  3. ShadowLab Research, Toronto, ON, Canada.
  4. Neurosciences Program, Alberta Children's Hospital, Calgary, Canada.
  5. Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada.
  6. Departments of Pediatrics, Clinical Neurosciences, and Psychology, University of Calgary, Calgary, Canada.
  7. Department of Neurology, Hospital for Sick Children, Toronto, Canada.
  8. McConnell Brain Imaging Centre, McGill University, Montreal, Canada.
  9. Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada.
  10. Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
  11. Children's Hospital of Philadelphia, Departments of Neurology and Pediatrics Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

PMID: 34872458 DOI: 10.1080/09297049.2021.2002289

Abstract

Long-term cognitive deficits have been observed in some children who experience an acquired demyelinating syndrome (ADS). We examined changes in cognitive functioning over the first two years following incident ADS andtested whether normalized brain and thalamic volume accounted for decline over time. Twenty-five youth (mean age 12.8 years) with ADS, 9 of whom were diagnosed with multiple sclerosis (MS) and 16 of whom experienced monophasic ADS (monoADS), underwent two neuropsychological evaluationsand MRI scans at approximately6- and 24-months post ADS-onset. We examined changes in cognitive outcomes over time and between patient groups. Generalized linear mixed-effect regression models were used to examine the association of normalized brain and thalamic volumesbetween the two timepointswith cognitive z-scores. Cognitive performance was within the age-expected range for both groups and remained stable over time on 15 measures. In the combined sample of monoADS and MS patients, declines (

Keywords: Multiple sclerosis; cognition; development; longitudinal; monophasic acquired demyelinating syndrome

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