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Suárez G, Robaina D, Muela A, et al. Is the suckling period and application pattern relevant for fluazuron against tick infestation in cows and their suckling calves?. BMC Vet Res. 2021;17(1):375doi: 10.1186/s12917-021-03090-7.
Suárez, G., Robaina, D., Muela, A., Tatiana, S., Puigvert, F., Alvariza, S., & Pareja, L. (2021). Is the suckling period and application pattern relevant for fluazuron against tick infestation in cows and their suckling calves?. BMC veterinary research, 17(1), 375. https://doi.org/10.1186/s12917-021-03090-7
Suárez, Gonzalo, et al. "Is the suckling period and application pattern relevant for fluazuron against tick infestation in cows and their suckling calves?." BMC veterinary research vol. 17,1 (2021): 375. doi: https://doi.org/10.1186/s12917-021-03090-7
Suárez G, Robaina D, Muela A, Tatiana S, Puigvert F, Alvariza S, Pareja L. Is the suckling period and application pattern relevant for fluazuron against tick infestation in cows and their suckling calves?. BMC Vet Res. 2021 Dec 06;17(1):375. doi: 10.1186/s12917-021-03090-7. PMID: 34872579; PMCID: PMC8647452.
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BMC Vet Res. 2021 Dec 06;17(1):375. doi: 10.1186/s12917-021-03090-7.

Is the suckling period and application pattern relevant for fluazuron against tick infestation in cows and their suckling calves?.

BMC veterinary research

Gonzalo Suárez, Diego Robaina, Agustina Muela, Saporiti Tatiana, Florencia Puigvert, Silvana Alvariza, Lucia Pareja

Affiliations

  1. Unidad de Farmacología y Terapéutica, Departamento Hospital y Clínicas Veterinarias, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay. [email protected].
  2. Unidad de Farmacología y Terapéutica, Departamento Hospital y Clínicas Veterinarias, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay.
  3. Grupo de Análisis de Compuestos Traza, Departamento de Química del Litoral, Cenur Litoral Norte, Universidad de la República, EEMAC, Ruta 3 Km 363, 60000, Paysandú, Uruguay.
  4. Unidad de bioquímica, Departamento de Biociencias, Facultad de Veterinaria, Universidad de la República, Montevideo, Uruguay.

PMID: 34872579 PMCID: PMC8647452 DOI: 10.1186/s12917-021-03090-7

Abstract

BACKGROUND: Fluazuron is a chitin synthesis inhibitor administered as a pour-on formulation in cattle for tick control. This study analyzes under endemic tick infestation, the incidence of the pour-on application pattern on the plasma levels of fluazuron in calves and cows in the lactation period of the beef cow. Two hundred and ninety-two beef cows around parturition were treated with a commercial pour-on formulation of fluazuron at a rate of 2.5 mg/kg of body weight. A total of 4 treatments were carried out on days 0, 32, 77, and 117. At each administration time, the cows were grouped according to the pour-on administration pattern: long (~ 60 cm pour-on application surface) and short (~ 30 cm pour-on application surface). Fluazuron levels in cows and calves plasma were determined before the third and fourth application for each subgroup (n = 10) by HPLC-MS/MS. During the entire study, cow-calf pairs were maintained under field conditions and qualitatively examined for tick infestation on the day of each treatment. Both treatments (long and short) schemes were designed to prevent the annual persistence of ticks.

RESULTS: No animals with presence of ticks were identified during the first 117 days of the study, except for three cows and one calf at the time of the third application (day 77). There were no differences after 40 days (day 77) post-treatment of the second application (30 ± 5 ppb vs. 28.5 ± 12 ppb, p > 0.05) and 45 days (day 117) after the third application (147 ± 55 ppb vs 140 ± 46 ppb, p > 0.05) between groups of cows treated with the long or short pour-on application, respectively. Plasma concentration of fluazuron at second and third application was increased (3.3 and 2.9 times, respectively) in calves under free suckling compared to cows. Nevertheless, both groups of cows and calves showed a significant increase in plasma concentration of fluazuron between times (4.9 times, p < 0.0001 and 2.8 times, p < 0.0001, respectively). In both groups, tick prevalence was 0% throughout the trial, except for day 77, which reached 1%.

CONCLUSIONS: The main conclusions of this study were the following: 1) Different administration patterns (long vs. short) did not differ in plasma levels of fluazuron.; 2) Given that only the cows were treated and lactating calves presented higher plasma levels of fluazuron than cows, passage through milk appears to be relevant and possibly due to a cumulative effect and continuous drug intake.

© 2021. The Author(s).

Keywords: Benzoylphenyl ureas; Cattle; Milk; Residues; Rhipicephalus microplus

References

  1. J Pharm Sci. 1988 Sep;77(9):796-8 - PubMed
  2. Vet Res. 2003 Jul-Aug;34(4):445-60 - PubMed
  3. Vet Parasitol. 2006 Feb 28;136(1):45-54 - PubMed
  4. J Vet Pharmacol Ther. 2004 Dec;27(6):467-77 - PubMed
  5. Int J Parasitol. 1996 Nov;26(11):1237-42 - PubMed
  6. Pharmaceutics. 2020 Feb 13;12(2): - PubMed
  7. Clin Pharmacokinet. 2010 Jul;49(7):421-38 - PubMed
  8. Parasite. 2019;26:26 - PubMed
  9. Vet Parasitol. 2014 Mar 17;201(1-2):128-36 - PubMed
  10. Br J Clin Pharmacol. 1992 May;33(5):501-5 - PubMed
  11. Exp Appl Acarol. 2018 Aug;75(4):383-398 - PubMed
  12. Vet Parasitol. 2006 Feb 28;136(1):29-43 - PubMed
  13. J Vet Pharmacol Ther. 2012 Oct;35(5):460-71 - PubMed

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