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Hoffmann T, Voigtländer H, Fröhlich E, et al. Single-Center-Studie: Evaluation der Sonografie beim Budd-Chiari-Syndrom. Single-center study: evaluation of sonography in Budd-Chiari syndrome. Z Gastroenterol. 2021;doi: 10.1055/a-1550-3141.
Hoffmann, T., Voigtländer, H., Fröhlich, E., Debove, I., & Pauluschke-Fröhlich, J. (2021). Single-Center-Studie: Evaluation der Sonografie beim Budd-Chiari-Syndrom. Single-center study: evaluation of sonography in Budd-Chiari syndrome. Zeitschrift fur Gastroenterologie, . https://doi.org/10.1055/a-1550-3141
Hoffmann, Tatjana, et al. "Single-Center-Studie: Evaluation der Sonografie beim Budd-Chiari-Syndrom." Single-center study: evaluation of sonography in Budd-Chiari syndrome. Zeitschrift fur Gastroenterologie vol. (2021). doi: https://doi.org/10.1055/a-1550-3141
Hoffmann T, Voigtländer H, Fröhlich E, Debove I, Pauluschke-Fröhlich J. Single-Center-Studie: Evaluation der Sonografie beim Budd-Chiari-Syndrom. Single-center study: evaluation of sonography in Budd-Chiari syndrome. Z Gastroenterol. 2021 Nov 15; doi: 10.1055/a-1550-3141. Epub 2021 Nov 15. PMID: 34781388.
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Z Gastroenterol. 2021 Nov 15; doi: 10.1055/a-1550-3141. Epub 2021 Nov 15.

Single-center study: evaluation of sonography in Budd-Chiari syndrome.

Zeitschrift fur Gastroenterologie

Tatjana Hoffmann, Hendrik Voigtländer, Eckhart Fröhlich, Ines Debove, Jan Pauluschke-Fröhlich

Affiliations

  1. Department of Internal Medicine 1 (Gastroenterology, Hepatology, Infectious Diseases), University Hospital Tübingen, Germany, Germany.
  2. Department of Neurology, Inselspital Bern University Hospital, University of Bern, Switzerland.
  3. Department of Womens Health, University Hospital Tübingen, Germany.

PMID: 34781388 DOI: 10.1055/a-1550-3141

Abstract

PURPOSE: Budd-Chiari syndrome (BCS) is a rare disease characterized by hepatic venous outflow tract obstruction. The study aimed to evaluate the diagnostic utility of ultrasound in confirming the diagnosis of BCS and to provide an overview of the clinical picture.

MATERIALS AND METHOD: In this retrospective single-center study, patients with an initial diagnosis of BCS were included. The files were analyzed concerning the ultrasound images and compared to computed tomography (CT) and magnetic resonance imaging (MRI). Main clinical signs of BCS were collected.

RESULTS: Data of 25 patients were analyzed. Doppler sonography showed the highest sensitivity (78.9%) with the highest specificity 97.4 (%) in confirming the correct diagnosis of BCS. Main imaging signs were obstruction in the hepatic veins (68.0%, 17/25 thrombotic), collaterals (91.7%, 11/12 intrahepatic), inhomogeneous liver parenchyma (7/21), and a hypertrophied lobus caudatus (18/21) (p < 0.01). All imaging signs could be detected with sonography. Hypertrophied lobus caudatus was seen exclusively in BCS. Furthermore, portal hypertension (9/25), liver cirrhosis (9/25), and ascites (19/25) can be diagnosed as non-specific signs of BCS (p < 0.01).The main clinical findings were elevated γ-GT levels in the laboratory (92.0%, 23/25, p < 0.01) and esophageal varices in endoscopy (12/25 p < 0.01). An association with myeloproliferative neoplasia (MPN) was frequently seen (10/25) (p < 0.01).

CONCLUSION: The present study demonstrates that sonography is an appropriate tool for the diagnosis of BCS and should be used as the first imaging procedure.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

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