Display options
Cite
Vreugdenhil M, Akkermans MD, van der Merwe LF, et al. Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries. Nutrients. 2021;13(11)doi: 10.3390/nu13113713.
Vreugdenhil, M., Akkermans, M. D., van der Merwe, L. F., van Elburg, R. M., van Goudoever, J. B., & Brus, F. (2021). Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries. Nutrients, 13(11), . https://doi.org/10.3390/nu13113713
Vreugdenhil, Mirjam, et al. "Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries." Nutrients vol. 13,11 (2021). doi: https://doi.org/10.3390/nu13113713
Vreugdenhil M, Akkermans MD, van der Merwe LF, van Elburg RM, van Goudoever JB, Brus F. Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries. Nutrients. 2021 Oct 22;13(11). doi: 10.3390/nu13113713. PMID: 34835970; PMCID: PMC8621620.
Copy Download .nbib Format: NLM
Share it on

Nutrients. 2021 Oct 22;13(11). doi: 10.3390/nu13113713.

Prevalence of Zinc Deficiency in Healthy 1-3-Year-Old Children from Three Western European Countries.

Nutrients

Mirjam Vreugdenhil, Marjolijn D Akkermans, Liandré F van der Merwe, Ruurd M van Elburg, Johannes B van Goudoever, Frank Brus

Affiliations

  1. Department of Pediatrics, Juliana Children's Hospital, Haga Teaching Hospital, 2545 AA The Hague, The Netherlands.
  2. Danone Nutricia Research, 3584 CT Utrecht, The Netherlands.
  3. Department of Pediatrics, Amsterdam UMC, Vrije Universiteit, University of Amsterdam Emma Children's Hospital, 1105 AZ Amsterdam, The Netherlands.
  4. Nutriton4Health, 1214 LT Hilversum, The Netherlands.

PMID: 34835970 PMCID: PMC8621620 DOI: 10.3390/nu13113713

Abstract

Zinc deficiency (ZnD) has adverse health consequences such as stunted growth. Since young children have an increased risk of developing ZnD, it is important to determine its prevalence and associated factors in this population. However, only a few studies have reported on ZnD prevalence in young children from Western high-income countries. This study evaluated ZnD prevalence and associated factors, including dietary Zn intake, in healthy 1-3-year-old children from Western European, high-income countries. ZnD was defined as serum Zn concentration <9.9 µmol/L. A total of 278 children were included with a median age of 1.7 years (Q1-Q3: 1.2-2.3). The median Zn concentration was 11.0 µmol/L (Q1-Q3: 9.0-12.2), and ZnD prevalence was 31.3%. No significant differences were observed in the socio-economic characteristics between children with and without ZnD. Dietary Zn intake was not associated with ZnD. ZnD is common in healthy 1-3-year-old children from Western European countries. However, the use of currently available cut-off values defining ZnD in young children has its limitations since these are largely based on reference values in older children. Moreover, these values were not evaluated in relation to health consequences, warranting further research.

Keywords: Western Europe; children; dietary zinc intake; zinc; zinc deficiency

References

  1. Nutrients. 2017 Jun 17;9(6): - PubMed
  2. Am J Clin Nutr. 2017 Feb;105(2):391-399 - PubMed
  3. Ann Clin Biochem. 2000 May;37 ( Pt 3):289-97 - PubMed
  4. Acta Paediatr. 1998 Jun;87(6):618-22 - PubMed
  5. Biol Trace Elem Res. 2004 Mar;97(3):197-214 - PubMed
  6. J Nutr. 2018 Sep 1;148(9):1399-1401 - PubMed
  7. J Am Diet Assoc. 2001 Apr;101(4):443-7 - PubMed
  8. Am J Clin Nutr. 2003 Oct;78(4):756-64 - PubMed
  9. Am Heart J. 2010 Apr;159(4):539-546.e2 - PubMed
  10. Am J Clin Nutr. 1980 Aug;33(8):1778-83 - PubMed
  11. Eur J Clin Nutr. 2010 May;64(5):510-7 - PubMed
  12. J Nutr. 2014 Aug;144(8):1204-10 - PubMed
  13. Int J Vitam Nutr Res. 1997;67(6):432-6 - PubMed
  14. Nutrients. 2018 Mar 20;10(3): - PubMed
  15. Am J Clin Nutr. 2009 Jun;89(6):2040S-2051S - PubMed
  16. Nutrients. 2020 Mar 13;12(3): - PubMed
  17. J Nutr. 2002 Oct;132(10):3061-6 - PubMed
  18. Nutrients. 2018 Mar 05;10(3): - PubMed
  19. Biol Trace Elem Res. 2003 Jul;94(1):33-40 - PubMed
  20. Annu Rev Nutr. 1994;14:449-69 - PubMed
  21. Nutrients. 2012 Aug;4(8):841-58 - PubMed
  22. BMC Public Health. 2011 Apr 13;11 Suppl 3:S22 - PubMed
  23. J Nutr. 2010 Dec;140(12):2221-6 - PubMed
  24. Food Nutr Bull. 2007 Sep;28(3 Suppl):S403-29 - PubMed
  25. J Nutr. 2000 May;130(5S Suppl):1350S-4S - PubMed
  26. J Trace Elem Electrolytes Health Dis. 1992 Jun;6(2):99-103 - PubMed
  27. J Nutr. 2018 Aug 1;148(8):1341-1351 - PubMed
  28. J Trace Elem Med Biol. 2020 Apr 23;61:126536 - PubMed
  29. Cochrane Database Syst Rev. 2014 May 15;(5):CD009384 - PubMed
  30. Eur J Clin Nutr. 2000 Oct;54(10):764-7 - PubMed
  31. Am J Clin Nutr. 1980 Apr;33(4):739-45 - PubMed
  32. Adv Nutr. 2013 Mar 01;4(2):176-90 - PubMed
  33. J Hum Nutr Diet. 2020 Oct;33(5):624-643 - PubMed
  34. J Nutr. 2000 May;130(5S Suppl):1378S-83S - PubMed
  35. J Nutr. 2000 May;130(5S Suppl):1360S-6S - PubMed
  36. Annu Rev Nutr. 2001;21:429-52 - PubMed
  37. Br J Nutr. 2012 Dec 14;108(11):1962-71 - PubMed
  38. Physiol Rev. 1993 Jan;73(1):79-118 - PubMed
  39. J Nutr. 1989 Jan;119(1):48-53 - PubMed
  40. J Pediatr Gastroenterol Nutr. 2014 Feb;58(2):193-8 - PubMed
  41. Proc Nutr Soc. 2006 Feb;65(1):51-60 - PubMed
  42. J Nutr. 2000 May;130(5S Suppl):1500S-8S - PubMed
  43. Nutrients. 2018 Feb 11;10(2): - PubMed

Publication Types