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Ling RR, Sim JJL, Tan FL, et al. Convalescent Plasma for Patients Hospitalized With Coronavirus Disease 2019: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Transfus Med Rev. 2021;doi: 10.1016/j.tmrv.2021.09.001.
Ling, R. R., Sim, J. J. L., Tan, F. L., Tai, B. C., Syn, N., Mucheli, S. S., Fan, B. E., Mitra, S., & Ramanathan, K. (2021). Convalescent Plasma for Patients Hospitalized With Coronavirus Disease 2019: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Transfusion medicine reviews, . https://doi.org/10.1016/j.tmrv.2021.09.001
Ling, Ryan Ruiyang, et al. "Convalescent Plasma for Patients Hospitalized With Coronavirus Disease 2019: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials." Transfusion medicine reviews vol. (2021). doi: https://doi.org/10.1016/j.tmrv.2021.09.001
Ling RR, Sim JJL, Tan FL, Tai BC, Syn N, Mucheli SS, Fan BE, Mitra S, Ramanathan K. Convalescent Plasma for Patients Hospitalized With Coronavirus Disease 2019: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials. Transfus Med Rev. 2021 Oct 10; doi: 10.1016/j.tmrv.2021.09.001. Epub 2021 Oct 10. PMID: 34782209; PMCID: PMC8502250.
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Transfus Med Rev. 2021 Oct 10; doi: 10.1016/j.tmrv.2021.09.001. Epub 2021 Oct 10.

Convalescent Plasma for Patients Hospitalized With Coronavirus Disease 2019: A Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials.

Transfusion medicine reviews

Ryan Ruiyang Ling, Jackie Jia Lin Sim, Felicia Liying Tan, Bee Choo Tai, Nicholas Syn, Sharavan Sadasiv Mucheli, Bingwen Eugene Fan, Saikat Mitra, Kollengode Ramanathan

Affiliations

  1. Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore.
  2. Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore.
  3. Department of Infectious Diseases, Tan Tock Seng Hospital, National Centre for Infectious Diseases, Singapore.
  4. Deparment of Haematology, Tan Tock Seng Hospital, Singapore.
  5. Lyell McEwin Hospital, Adelaide, South Australia, Australia.
  6. Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Cardiothoracic Intensive Care Unit, National University Heart Centre, National University Hospital, Singapore. Electronic address: [email protected].

PMID: 34782209 PMCID: PMC8502250 DOI: 10.1016/j.tmrv.2021.09.001

Abstract

Current evidence from randomized controlled trials (RCTs) and systematic reviews on the utility of convalescent plasma (CP) in patients with coronavirus disease 2019 (COVID-19) suggests a lack of benefit. We conducted an updated meta-analysis of RCTs with trial sequential analysis to investigate whether convalescent plasma is futile in reducing mortality in patients hospitalized with COVID-19. We searched 6 databases from December 1, 2019 to August 1, 2021 for RCTs comparing the use of CP with standard of care or transfusion of non-CP standard plasma in patients with COVID-19. The risk of bias was assessed using the Cochrane Risk-of-Bias 2 Tool. Random effects (DerSimonian and Laird) meta-analyses were conducted. The primary outcome was the aggregate risk for in-hospital mortality between both arms. We conducted a trial sequential analysis (TSA) based on the pooled relative risks (RRs) for in-hospital mortality. Secondary outcomes included the pooled RR for receipt of mechanical ventilation and mean difference in hospital length of stay. We included 18 RCTs (8702 CP, 7906 control). CP was not associated with a significant mortality benefit (RR: 0.95, 95%-CI: 0.86-1.04, P = .27, high certainty). Subgroup analysis did not find any significant differences (p

Copyright © 2021. Published by Elsevier Inc.

Keywords: Convalescent plasma; Coronavirus disease 2019; Meta-analysis; Mortality; Severe acute respiratory syndrome coronavirus 2

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