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Chritinin DF, Sumarokova MA, Shchukina EP, et al. Osobennosti terapii antidepressantami bol'nykh shizoaffektivnym rasstroistvom v mezhpristupnom periode. [Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period]. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(10):78-81doi: 10.17116/jnevro202112110178.
Chritinin, D. F., Sumarokova, M. A., Shchukina, E. P., & Morozova, V. D. (2021). Osobennosti terapii antidepressantami bol'nykh shizoaffektivnym rasstroistvom v mezhpristupnom periode. [Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 121(10), 78-81. https://doi.org/10.17116/jnevro202112110178
Chritinin, D F, et al. "Osobennosti terapii antidepressantami bol'nykh shizoaffektivnym rasstroistvom v mezhpristupnom periode." [Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova vol. 121,10 (2021): 78-81. doi: https://doi.org/10.17116/jnevro202112110178
Chritinin DF, Sumarokova MA, Shchukina EP, Morozova VD. Osobennosti terapii antidepressantami bol'nykh shizoaffektivnym rasstroistvom v mezhpristupnom periode. [Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period]. Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(10):78-81. doi: 10.17116/jnevro202112110178. Russian. PMID: 34874659.
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Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(10):78-81. doi: 10.17116/jnevro202112110178.

[Peculiarities of treatment with antidepressants in patients with schizoaffective disorder in the interictal period].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Article in Russian]
D F Chritinin, M A Sumarokova, E P Shchukina, V D Morozova

Affiliations

  1. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
  2. Private educational institution of continuing professional education «Milton Erickson Institute», Moscow, Russia.

PMID: 34874659 DOI: 10.17116/jnevro202112110178

Abstract

OBJECTIVE: To investigate the effect of therapy with various classes of antidepressants on the quality of remission and adherence to therapy in patients with schizoaffective disorder (SAD) in remission.

MATERIAL AND METHODS: We examined 87 outpatients, including 29 men (33.33%), 58 women (66.67%) diagnosed with SAD according to ICD-10 criteria (item F25), in whom 341 cases of remission were studied. The average age of the patients was 41.40±12.56 years. Cases of remission in patients receiving therapy with nonselective monoamine reuptake inhibitors (NSMRIs) were included in group 1 (

RESULTS: In both groups, mood disorders in remission were represented by subdepression. Delusional disorders at the stage of remission were almost 7 times more common in group 1 (12.28%), compared with group 2 (1.77%). The duration of the interictal period in patients treated with NSMRIs was higher (504.0±60.67 days) compared with patients receiving SNRI (176.46±17.88 days). In group 2, residual affective-delusional symptoms in remission were significantly less common. Cases of refusal from therapy in group 2 were 12 times less frequent, which indicates a greater adherence to therapy in patients receiving SNRI.

CONCLUSION: It is possible to recommend treatment with NSMRIs for patients with depressive affect in the structure of SAD to increase the duration of the interictal period. At the same time, for patients with SAD in the presence of delusional and affective-delusional symptoms, it is preferable to prescribe SNRI.

Keywords: anti-relapse therapy; antidepressants; depression; schizoaffective disorder; treatment

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