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Haug EB, Markovitz AR, Fraser A, et al. The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study. Sci Rep. 2021;11(1):22981doi: 10.1038/s41598-021-99478-4.
Haug, E. B., Markovitz, A. R., Fraser, A., Dalen, H., Romundstad, P. R., Åsvold, B. O., Rich-Edwards, J. W., & Horn, J. (2021). The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study. Scientific reports, 11(1), 22981. https://doi.org/10.1038/s41598-021-99478-4
Haug, Eirin B, et al. "The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study." Scientific reports vol. 11,1 (2021): 22981. doi: https://doi.org/10.1038/s41598-021-99478-4
Haug EB, Markovitz AR, Fraser A, Dalen H, Romundstad PR, Åsvold BO, Rich-Edwards JW, Horn J. The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study. Sci Rep. 2021 Nov 26;11(1):22981. doi: 10.1038/s41598-021-99478-4. PMID: 34837029; PMCID: PMC8626478.
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Sci Rep. 2021 Nov 26;11(1):22981. doi: 10.1038/s41598-021-99478-4.

The role of cardiovascular risk factors in maternal cardiovascular disease according to offspring birth characteristics in the HUNT study.

Scientific reports

Eirin B Haug, Amanda R Markovitz, Abigail Fraser, Håvard Dalen, Pål R Romundstad, Bjørn O Åsvold, Janet W Rich-Edwards, Julie Horn

Affiliations

  1. Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Postboks 8905, 7491, Trondheim, Norway. [email protected].
  2. Department of Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. [email protected].
  3. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.
  4. Division of Women's Health, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
  5. Mathematica, Cambridge, MA, USA.
  6. Department of Population Health Sciences, Bristol Medical School and MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, UK.
  7. Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.
  8. Department of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  9. Clinic of Cardiology, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  10. Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  11. Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, K.G. Jebsen Center for Genetic Epidemiology, NTNU, Norwegian University of Science and Technology, Postboks 8905, 7491, Trondheim, Norway.
  12. Department of Endocrinology, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  13. Department of Obstetrics and Gynecology, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway.

PMID: 34837029 PMCID: PMC8626478 DOI: 10.1038/s41598-021-99478-4

Abstract

A history of preterm or small (SGA) or large (LGA) for gestational age offspring is associated with smoking and unfavorable levels of BMI, blood pressure, glucose and lipids. Whether and to what extent the excess cardiovascular risk observed in women with these pregnancy complications is explained by conventional cardiovascular risk factors (CVRFs) is not known. We examined the association between a history of SGA, LGA or preterm birth and cardiovascular disease among 23,284 parous women and quantified the contribution of individual CVRFs to the excess cardiovascular risk using an inverse odds weighting approach. The hazard ratios (HR) between SGA and LGA offspring and CVD were 1.30 (95% confidence interval (CI) 1.15, 1.48) and 0.89 (95% CI 0.76, 1.03), respectively. Smoking explained 49% and blood pressure may have explained ≈12% of the excess cardiovascular risk in women with SGA offspring. Women with preterm birth had a 24% increased risk of CVD (HR 1.24, 95% CI 1.06, 1.45), but we found no evidence for CVRFs explaining any of this excess cardiovascular risk. While smoking explains a substantial proportion of excess cardiovascular risk in women with SGA offspring and blood pressure may explain a small proportion in these women, we found no evidence that conventional CVRFs explain any of the excess cardiovascular risk in women with preterm birth.

© 2021. The Author(s).

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