Display options
Cite
Dixon AE, Blake KV, DiMango EA, et al. The challenge of addressing obesity in people with poorly controlled asthma. Obes Sci Pract. 2021;7(6):682-689doi: 10.1002/osp4.533.
Dixon, A. E., Blake, K. V., DiMango, E. A., Dransfield, M. T., Feemster, L. C., Johnson, O., Roy, G., Hazucha, H., Harvey, J., McCormack, M. C., Wise, R. A., & Holbrook, J. T. (2021). The challenge of addressing obesity in people with poorly controlled asthma. Obesity science & practice, 7(6), 682-689. https://doi.org/10.1002/osp4.533
Dixon, Anne E, et al. "The challenge of addressing obesity in people with poorly controlled asthma." Obesity science & practice vol. 7,6 (2021): 682-689. doi: https://doi.org/10.1002/osp4.533
Dixon AE, Blake KV, DiMango EA, Dransfield MT, Feemster LC, Johnson O, Roy G, Hazucha H, Harvey J, McCormack MC, Wise RA, Holbrook JT. The challenge of addressing obesity in people with poorly controlled asthma. Obes Sci Pract. 2021 May 25;7(6):682-689. doi: 10.1002/osp4.533. eCollection 2021 Dec. PMID: 34877007; PMCID: PMC8633940.
Copy Download .nbib Format: NLM
Share it on

Obes Sci Pract. 2021 May 25;7(6):682-689. doi: 10.1002/osp4.533. eCollection 2021 Dec.

The challenge of addressing obesity in people with poorly controlled asthma.

Obesity science & practice

Anne E Dixon, Kathryn V Blake, Emily A DiMango, Mark T Dransfield, Laura C Feemster, Olivia Johnson, Gem Roy, Heather Hazucha, Jean Harvey, Meredith C McCormack, Robert A Wise, Janet T Holbrook

Affiliations

  1. University of Vermont Burlington Vermont USA.
  2. Nemours Children's Health Jacksonville Florida USA.
  3. Columbia University New York New York USA.
  4. University of Alabama Birmingham Alabama USA.
  5. Veterans Affairs Puget Sound Health Care System Seattle Washington USA.
  6. Center for Clinical Trials Johns Hopkins Bloomberg School of Public Health Baltimore Maryland USA.

PMID: 34877007 PMCID: PMC8633940 DOI: 10.1002/osp4.533

Abstract

OBJECTIVE: There is a high prevalence of obesity in people with asthma, and obesity is associated with poorly controlled asthma. Significant weight loss might improve asthma control: the purpose of this study was to investigate patient characteristics and factors that might affect implementation of a weight loss and/or roflumilast intervention, to target both obesity and asthma.

METHODS: A cross-sectional study of people with obesity and poorly controlled asthma performed at 13 sites across the United States.

RESULTS: One hundred and two people participated in this study. Median BMI was 37 (IQR 35-42). The majority, 55%, were African American and 76% were female. Fifty two percent had very poorly controlled asthma. Most participants were quite sedentary (70% reported being inactive or participating only in light-intensity activities according to the Stanford Brief Activity Survey). Participants reported significant impairments related to physical function on the Impact of Weight on Quality of Life-Lite questionnaire (median score 67 [IQR 41-84]). Thirty-five percent of participants reported mild, and 2 % moderate, depressive symptoms as assessed by the Patient Health Questionnaire-9.

CONCLUSIONS: Poorly controlled asthma and obesity often affect minority populations and are associated with significant impairments in health related to physical function and low levels of physical activity that might complicate efforts to lose weight. Interventions targeted at poorly controlled asthma associated with obesity in the United States need to address factors complicating health in underserved communities, such as increasing opportunities for physical activity, while also managing activity limitations related to the combination of asthma and obesity.

© 2021 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.

Keywords: exercise; lung function; nutrition; obesity; weight loss

Conflict of interest statement

Anne E. Dixon reports grants from the NIH and ALA, and personal fees from UpToDate and Springer. Kathryn V. Blake reports grants from NIH, ALA, and Propeller Health. Emily A. DiMango reports no confli

References

  1. Am J Respir Crit Care Med. 2017 Jan 1;195(1):32-42 - PubMed
  2. J Allergy Clin Immunol. 2011 Sep;128(3):508-15.e1-2 - PubMed
  3. Cogent Med. 2019;6(1): - PubMed
  4. J Affect Disord. 2020 Mar 15;265:395-401 - PubMed
  5. Ann Glob Health. 2019 Jan 22;85(1): - PubMed
  6. Curr Obes Rep. 2020 Dec;9(4):562-570 - PubMed
  7. N Engl J Med. 2017 Feb 16;376(7):641-651 - PubMed
  8. Int J Clin Res Trials. 2019;4(1): - PubMed
  9. Health Econ. 1993 Oct;2(3):217-27 - PubMed
  10. Chest. 1998 Oct;114(4):998-1007 - PubMed
  11. Curr Med Res Opin. 2016;32(3):485-508 - PubMed
  12. Am J Respir Crit Care Med. 2012 Oct 1;186(7):598-605 - PubMed
  13. Int J Environ Res Public Health. 2019 Apr 03;16(7): - PubMed
  14. Int J Obes (Lond). 2013 Aug;37 Suppl 1:S25-30 - PubMed
  15. J Gen Intern Med. 2001 Sep;16(9):606-13 - PubMed
  16. Cancer Epidemiol Biomarkers Prev. 1999 Oct;8(10):941-6 - PubMed
  17. Am Psychol. 2020 Feb-Mar;75(2):252-264 - PubMed
  18. Am J Epidemiol. 2006 Sep 15;164(6):598-606 - PubMed
  19. BMC Pulm Med. 2015 May 07;15:56 - PubMed
  20. Circulation. 2002 Dec 17;106(25):3143-421 - PubMed
  21. Arch Intern Med. 2006 May 22;166(10):1092-7 - PubMed
  22. J Gen Intern Med. 2013 Feb;28(2):231-8 - PubMed
  23. NCHS Data Brief. 2016 Mar;(239):1-8 - PubMed
  24. Obes Res. 2001 Feb;9(2):102-11 - PubMed
  25. Eur Respir J. 2005 Aug;26(2):319-38 - PubMed
  26. Clin Exp Allergy. 2013 Jan;43(1):36-49 - PubMed
  27. Pulm Pharmacol Ther. 2015 Dec;35 Suppl:S20-7 - PubMed
  28. Clin Obes. 2018 Feb;8(1):1-10 - PubMed
  29. J Allergy Clin Immunol. 2006 Mar;117(3):549-56 - PubMed
  30. Med Care. 2004 Dec;42(12):1194-201 - PubMed
  31. Mol Psychiatry. 2019 Jan;24(1):18-33 - PubMed
  32. J Asthma. 2007 Oct;44(8):651-8 - PubMed
  33. J Allergy Clin Immunol. 2018 Apr;141(4):1169-1179 - PubMed
  34. Am Psychol. 2020 Feb-Mar;75(2):274-289 - PubMed
  35. Prev Chronic Dis. 2017 Mar 16;14:E24 - PubMed
  36. Am J Respir Cell Mol Biol. 2016 Jul;55(1):82-91 - PubMed
  37. J Clin Epidemiol. 1993 Oct;46(10):1103-11 - PubMed
  38. J Pediatr Nurs. 2009 Apr;24(2):81-9 - PubMed
  39. J Clin Epidemiol. 2003 May;56(5):395-407 - PubMed
  40. Expert Opin Drug Saf. 2016 Aug;15(8):1133-46 - PubMed
  41. Dig Dis Sci. 1988 Feb;33(2):129-34 - PubMed

Publication Types