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Wang G, Bhatta L, Moen GH, et al. Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension. 2021;79(1):170-177doi: 10.1161/HYPERTENSIONAHA.121.17701.
Wang, G., Bhatta, L., Moen, G. H., Hwang, L. D., Kemp, J. P., Bond, T. A., Åsvold, B. O., Brumpton, B., Evans, D. M., & Warrington, N. M. (2022). Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension (Dallas, Tex. : 1979), 79(1), 170-177. https://doi.org/10.1161/HYPERTENSIONAHA.121.17701
Wang, Geng, et al. "Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health." Hypertension (Dallas, Tex. : 1979) vol. 79,1 (2022): 170-177. doi: https://doi.org/10.1161/HYPERTENSIONAHA.121.17701
Wang G, Bhatta L, Moen GH, Hwang LD, Kemp JP, Bond TA, Åsvold BO, Brumpton B, Evans DM, Warrington NM. Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health. Hypertension. 2022 Jan;79(1):170-177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Epub 2021 Nov 17. PMID: 34784738; PMCID: PMC8654122.
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Hypertension. 2022 Jan;79(1):170-177. doi: 10.1161/HYPERTENSIONAHA.121.17701. Epub 2021 Nov 17.

Investigating a Potential Causal Relationship Between Maternal Blood Pressure During Pregnancy and Future Offspring Cardiometabolic Health.

Hypertension (Dallas, Tex. : 1979)

Geng Wang, Laxmi Bhatta, Gunn-Helen Moen, Liang-Dar Hwang, John P Kemp, Tom A Bond, Bjørn Olav Åsvold, Ben Brumpton, David M Evans, Nicole M Warrington

Affiliations

  1. The University of Queensland Diamantina Institute (G.W., G.-H.M., L.-D.H., J.P.K., T.A.B., D.M.E., N.M.W.), The University of Queensland, Brisbane, Australia.
  2. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway (L.B., G.-H.M., B.O.A., B.B., N.M.W.).
  3. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway (G.-H.M.).
  4. Population Health Sciences, Bristol Medical School (G.-H.M., T.A.B.), University of Bristol, United Kingdom.
  5. Institute of Molecular Bioscience (L.-D.H., J.P.K., D.M.E., N.M.W.), The University of Queensland, Brisbane, Australia.
  6. Medical Research Council Integrative Epidemiology Unit (J.P.K., T.A.B., D.M.E., N.M.W.), University of Bristol, United Kingdom.
  7. Department of Endocrinology, Clinic of Medicine (B.O.A.), St Olavs Hospital, Trondheim University Hospital, Norway.
  8. HUNT Research Center, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Levanger, Norway (B.O.A., B.B.).
  9. Clinic of Medicine (B.B.), St Olavs Hospital, Trondheim University Hospital, Norway.

PMID: 34784738 PMCID: PMC8654122 DOI: 10.1161/HYPERTENSIONAHA.121.17701

Abstract

Observational epidemiological studies have reported that higher maternal blood pressure (BP) during pregnancy is associated with increased future risk of offspring cardiometabolic disease. However, it is unclear whether this association represents a causal relationship through intrauterine mechanisms. We used a Mendelian randomization (MR) framework to examine the relationship between unweighted maternal genetic scores for systolic BP and diastolic BP and a range of cardiometabolic risk factors in the offspring of up to 29 708 genotyped mother-offspring pairs from the UKB study (UK Biobank) and the HUNT study (Trøndelag Health). We conducted similar analyses in up to 21 423 father-offspring pairs from the same cohorts. We confirmed that the BP-associated genetic variants from the general population sample also had similar effects on maternal BP during pregnancy in independent cohorts. We did not detect any association between maternal (or paternal) unweighted genetic scores and cardiometabolic offspring outcomes in the meta-analysis of UKB and HUNT after adjusting for offspring genotypes at the same loci. We find little evidence to support the notion that maternal BP is a major causal risk factor for adverse offspring cardiometabolic outcomes in later life.

Keywords: Mendelian randomization analysis; adult children; blood pressure; cardiometabolic risk factors; cohort studies; genotype; pregnancy

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