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Acón M, Geiß C, Torres-Calvo J, et al. . iScience. 2021;24(12):103407doi: 10.1016/j.isci.2021.103407.
Acón, M., Geiß, C., Torres-Calvo, J., Bravo-Estupiñan, D., Oviedo, G., Arias-Arias, J. L., Rojas-Matey, L. A., Edwin, B., Vásquez-Vargas, G., Oses-Vargas, Y., Guevara-Coto, J., Segura-Castillo, A., Siles-Canales, F., Quirós-Barrantes, S., Régnier-Vigouroux, A., Mendes, P., & Mora-Rodríguez, R. (2021). . iScience, 24(12), 103407. https://doi.org/10.1016/j.isci.2021.103407
Acón, ManSai, et al. "." iScience vol. 24,12 (2021): 103407. doi: https://doi.org/10.1016/j.isci.2021.103407
Acón M, Geiß C, Torres-Calvo J, Bravo-Estupiñan D, Oviedo G, Arias-Arias JL, Rojas-Matey LA, Edwin B, Vásquez-Vargas G, Oses-Vargas Y, Guevara-Coto J, Segura-Castillo A, Siles-Canales F, Quirós-Barrantes S, Régnier-Vigouroux A, Mendes P, Mora-Rodríguez R. . iScience. 2021 Nov 08;24(12):103407. doi: 10.1016/j.isci.2021.103407. eCollection 2021 Dec 17. PMID: 34877484; PMCID: PMC8627999.
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iScience. 2021 Nov 08;24(12):103407. doi: 10.1016/j.isci.2021.103407. eCollection 2021 Dec 17.

[No title available]

iScience

ManSai Acón, Carsten Geiß, Jorge Torres-Calvo, Diana Bravo-Estupiñan, Guillermo Oviedo, Jorge L Arias-Arias, Luis A Rojas-Matey, Baez Edwin, Gloriana Vásquez-Vargas, Yendry Oses-Vargas, José Guevara-Coto, Andrés Segura-Castillo, Francisco Siles-Canales, Steve Quirós-Barrantes, Anne Régnier-Vigouroux, Pedro Mendes, Rodrigo Mora-Rodríguez

Affiliations

  1. Lab of Tumor Chemosensitivity (LQT), Research Center for Tropical Diseases (CIET), Faculty of Microbiology, University of Costa Rica, 11501-2060 San José, Costa Rica.
  2. Master Program on Bioinformatics and Systems Biology, Postgraduate Program SEP, University of Costa Rica, 11501-2060 San José, Costa Rica.
  3. Institute for Developmental Biology and Neurobiology, Johannes Gutenberg University, 55128 Mainz, Germany.
  4. Ph.D. Program in Sciences, Postgraduate Program SEP, University of Costa Rica, 11501-2060 San José, Costa Rica.
  5. School of Computer Sciences and Informatics (ECCI), University of Costa Rica, San Jose Costa Rica, 11501-2060 San José, Costa Rica.
  6. Laboratorio de Investigación e Innovación Tecnológica, Universidad Estatal a Distancia (UNED), 474-2050 San José, Costa Rica.
  7. Pattern Recognition and Intelligent Systems Laboratory, Department of Electrical Engineering, Universidad de Costa Rica, 11501-2060 San José, Costa Rica.
  8. DC Lab, Lab of Surgery and Cancer, University of Costa Rica, 11501-2060 San José, Costa Rica.
  9. Center for Cell Analysis and Modeling and Department of Cell Biology, University of Connecticut School of Medicine, Farmington, 06030 CT, USA.

PMID: 34877484 PMCID: PMC8627999 DOI: 10.1016/j.isci.2021.103407

Abstract

We hypothesize that dosage compensation of critical genes arises from systems-level properties for cancer cells to withstand the negative effects of aneuploidy. We identified several candidate genes in cancer multiomics data and developed a biocomputational platform to construct a mathematical model of their interaction network with micro-RNAs and transcription factors, where the property of dosage compensation emerged for

© 2021 The Author(s).

Keywords: Bioinformatics; Mathematical biosciences; Systems biology

Conflict of interest statement

The authors declare no competing interests.

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