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Morales E, Alcantara-Lopez MV, Cabezas-Herrera J, et al. The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods. Paediatr Perinat Epidemiol. 2021;doi: 10.1111/ppe.12826.
Morales, E., Alcantara-Lopez, M. V., Cabezas-Herrera, J., de Diego, T., Hernandez-Caselles, T., Jimenez-Guerrero, P., Larque, E., Lopez-Soler, C., Martinez-Gracia, C., Martinez-Torres, A., Martin-Orozco, E., Mendiola, J., Nieto-Díaz, A., Noguera, J. A., Perez-Fernandez, V., Prieto-Sánchez, M. T., Salvador-Garcia, C., Sanchez-Solis, M., Santaella-Pascual, M., Sola-Martinez, R. A., Torres-Cantero, A., Yagüe-Guirao, G., Zornoza-Moreno, M., Garcia-Marcos, L. (2021). The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods. Paediatric and perinatal epidemiology, . https://doi.org/10.1111/ppe.12826
Morales, Eva, et al. "The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods." Paediatric and perinatal epidemiology vol. (2021). doi: https://doi.org/10.1111/ppe.12826
Morales E, Alcantara-Lopez MV, Cabezas-Herrera J, de Diego T, Hernandez-Caselles T, Jimenez-Guerrero P, Larque E, Lopez-Soler C, Martinez-Gracia C, Martinez-Torres A, Martin-Orozco E, Mendiola J, Nieto-Díaz A, Noguera JA, Perez-Fernandez V, Prieto-Sánchez MT, Salvador-Garcia C, Sanchez-Solis M, Santaella-Pascual M, Sola-Martinez RA, Torres-Cantero A, Yagüe-Guirao G, Zornoza-Moreno M, Garcia-Marcos L. The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods. Paediatr Perinat Epidemiol. 2021 Nov 28; doi: 10.1111/ppe.12826. Epub 2021 Nov 28. PMID: 34841558.
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Paediatr Perinat Epidemiol. 2021 Nov 28; doi: 10.1111/ppe.12826. Epub 2021 Nov 28.

The Nutrition in Early Life and Asthma (NELA) birth cohort study: Rationale, design, and methods.

Paediatric and perinatal epidemiology

Eva Morales, Maria V Alcantara-Lopez, Juan Cabezas-Herrera, Teresa de Diego, Trinidad Hernandez-Caselles, Pedro Jimenez-Guerrero, Elvira Larque, Concepción Lopez-Soler, Carmen Martinez-Gracia, Antonela Martinez-Torres, Elena Martin-Orozco, Jaime Mendiola, Anibal Nieto-Díaz, Jose A Noguera, Virginia Perez-Fernandez, M Teresa Prieto-Sánchez, Carme Salvador-Garcia, Manuel Sanchez-Solis, Marina Santaella-Pascual, Rosa A Sola-Martinez, Alberto Torres-Cantero, Genoveva Yagüe-Guirao, Matilde Zornoza-Moreno, Luis Garcia-Marcos,

Affiliations

  1. Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
  2. Department of Public Health Sciences, University of Murcia, Murcia, Spain.
  3. Paediatric Psychology Unit, "Virgen de la Arrixaca" Children's University Clinical Hospital, University of Murcia, Murcia, Spain.
  4. Molecular Therapy and Biomarkers Research Group, "Virgen de la Arrixaca" University Clinical Hospital, University of Murcia, Murcia, Spain.
  5. Department of Biochemistry, Molecular Biology, University of Murcia, Murcia, Spain.
  6. Regional Atmospheric Modelling Group, Department of Physics, University of Murcia, Murcia, Spain.
  7. Department of Physiology, University of Murcia, Murcia, Spain.
  8. Maternal and Children Health Network (SAMID III), Murcia, Spain.
  9. Paediatric and Adolescent Clinical Psychology University Research Group (GUIIA-PC), University of Murcia, Murcia, Spain.
  10. Department of Food Science and Technology, University of Murcia, Murcia, Spain.
  11. Paediatric Respiratory and Allergy Units, "Virgen de la Arrixaca" Children's University Clinical Hospital, University of Murcia, Murcia, Spain.
  12. Materno-Fetal Medicine Unit, Obstetrics and Gynaecology Service, "Virgen de la Arrixaca" University Clinical Hospital, University of Murcia, Murcia, Spain.
  13. Molecular Therapy and Biomarkers Research Group, Clinical Analysis Service, University Clinical Hospital, Murcia, Spain.
  14. Microbiology Service, General University Hospital Consortium, University of Valencia, Valencia, Spain.
  15. Preventive Medicine Service, "Virgen de la Arrixaca" University Clinical Hospital, University of Murcia, Murcia, Spain.
  16. Microbiology Service, "Virgen de la Arrixaca" University Clinical Hospital, University of Murcia, Murcia, Spain.
  17. Department of Genetics and Microbiology, University of Murcia, Murcia, Spain.
  18. "Vistalegre-La Flota" Health Center, Health System of Murcia (SMS), Murcia, Spain.
  19. Network of Asthma and Adverse and Allergic Reactions (ARADyAL), Murcia, Spain.

PMID: 34841558 DOI: 10.1111/ppe.12826

Abstract

BACKGROUND: Primary prevention strategies for asthma are lacking. Its inception probably starts in utero and/or during the early postnatal period as the developmental origins of health and disease (DOHaD) paradigm suggests.

OBJECTIVES: The main objective of Nutrition in Early Life and Asthma (NELA) cohort study is to unravel whether the following factors contribute causally to the developmental origins of asthma: (1) maternal obesity/adiposity and foetal growth; (2) maternal and child nutrition; (3) outdoor air pollution; (4) endocrine disruptors; and (5) maternal psychological stress. Maternal and offspring biological samples are used to assess changes in offspring microbiome, immune system, epigenome and volatilome as potential mechanisms influencing disease susceptibility.

POPULATION: Randomly selected pregnant women from three health areas of Murcia, a south-eastern Mediterranean region of Spain, who fulfilled the inclusion criteria were invited to participate at the time of the follow-up visit for routine foetal anatomy scan at 19-22 weeks of gestation, at the Maternal-Fetal Medicine Unit of the "Virgen de la Arrixaca" University Clinical Hospital over a 36-month period, from March 2015 to April 2018.

DESIGN: Prospective, population-based, maternal-child, birth cohort study.

METHODS: Questionnaires on exposures and outcome variables were administered to mothers at 20-24 gestation week; 32-36 gestation week; and delivery. Children were surveyed at birth, 3 and 18 months of age and currently at 5 years. Furthermore, physical examinations were performed; and different measurements and biological samples were obtained at these time points.

PRELIMINARY RESULTS: Among the 1350 women invited to participate, 738 (54%) were finally enrolled in the study and 720 of their children were eligible at birth. The adherence was high with 612 children (83%) attending the 3 months' visit and 532 children (72%) attending the 18 months' visit.

CONCLUSION: The NELA cohort will add original and unique knowledge to the developmental origins of asthma.

© 2021 The Authors. Paediatric and Perinatal Epidemiology published by John Wiley & Sons Ltd.

Keywords: allergy; asthma; diet; mother-child cohort; wheezing

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