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J Virol. 2021 Nov 17;JVI0161421. doi: 10.1128/JVI.01614-21. Epub 2021 Nov 17.

The Combined Expression of the Non-structural Protein NS1 and the N-Terminal Half of NS2 (NS2.

Journal of virology

Sergio Utrilla-Trigo, Luis Jiménez-Cabello, Eva Calvo-Pinilla, Alejandro Marín-López, Gema Lorenzo, Pedro Sánchez-Cordón, Sandra Moreno, Julio Benavides, Sarah Gilbert, Aitor Nogales, Javier Ortego

Affiliations

  1. Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA-CSIC), Valdeolmos, 28130 Madrid, Spain.
  2. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06519, USA.
  3. Instituto de Ganadería de Montaña (CSIC-Universidad de León), 24346 León, Spain.
  4. The Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.

PMID: 34787454 DOI: 10.1128/JVI.01614-21

Abstract

Bluetongue, caused by bluetongue virus (BTV), is a widespread arthropod-borne disease of ruminants that entails a recurrent threat to the primary sector of developed and developing countries. In this work, we report MVA and ChAdOx1-vectored vaccines designed to simultaneously express the immunogenic NS1 protein and/or NS2-Nt, the N-terminal half of protein NS2 (NS2

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