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Meister J, Bone DBJ, Knudsen JR, et al. In vivo metabolic effects after acute activation of skeletal muscle G. Mol Metab. 2021;101415doi: 10.1016/j.molmet.2021.101415.
Meister, J., Bone, D. B. J., Knudsen, J. R., Barella, L. F., Liu, L., Lee, R., Gavrilova, O., Chen, M., Weinstein, L. S., Kleinert, M., Jensen, T. E., & Wess, J. R. (2021). In vivo metabolic effects after acute activation of skeletal muscle G. Molecular metabolism, 101415. https://doi.org/10.1016/j.molmet.2021.101415
Meister, Jaroslawna, et al. "In vivo metabolic effects after acute activation of skeletal muscle G." Molecular metabolism vol. (2021): 101415. doi: https://doi.org/10.1016/j.molmet.2021.101415
Meister J, Bone DBJ, Knudsen JR, Barella LF, Liu L, Lee R, Gavrilova O, Chen M, Weinstein LS, Kleinert M, Jensen TE, Wess JR. In vivo metabolic effects after acute activation of skeletal muscle G. Mol Metab. 2021 Dec 06;101415. doi: 10.1016/j.molmet.2021.101415. Epub 2021 Dec 06. PMID: 34883278.
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Mol Metab. 2021 Dec 06;101415. doi: 10.1016/j.molmet.2021.101415. Epub 2021 Dec 06.

In vivo metabolic effects after acute activation of skeletal muscle G.

Molecular metabolism

Jaroslawna Meister, Derek B J Bone, Jonas R Knudsen, Luiz F Barella, Liu Liu, Regina Lee, Oksana Gavrilova, Min Chen, Lee S Weinstein, Maximilian Kleinert, Thomas E Jensen, Ju Rgen Wess

Affiliations

  1. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA. Electronic address: [email protected].
  2. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
  3. Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark.
  4. Mouse Metabolism Core, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA.
  5. Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
  6. Department of Nutrition, Exercise and Sports, University of Copenhagen, Denmark; Muscle Physiology and Metabolism Group, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany.
  7. Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 20892, USA; Laboratory of Bioorganic Chemistry, Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bldg. 8A, Room B1A-05, 8 Center Drive, Bethesda, Maryland 20892, USA. Electronic address: [email protected].

PMID: 34883278 DOI: 10.1016/j.molmet.2021.101415

Abstract

OBJECTIVE: The goal of this study was to determine the glucometabolic effects of acute activation of G

METHODS: To address this question, we studied mice that express a G

RESULTS: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice by decreasing glucose uptake selectively into SKM. However, the acute metabolic effects following agonist activation of β

CONCLUSION: Selective activation of G

Copyright © 2021. Published by Elsevier GmbH.

Keywords: Clenbuterol; DREADD; G protein; GPCR; Glucose homeostasis; Skeletal muscle; Urocortin 2

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