Display options
Cite
Bosman M, Krüger DN, Favere K, et al. Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312812.
Bosman, M., Krüger, D. N., Favere, K., Wesley, C. D., Neutel, C. H. G., Van Asbroeck, B., Diebels, O. R., Faes, B., Schenk, T. J., Martinet, W., De Meyer, G. R. Y., Van Craenenbroeck, E. M., & Guns, P. D. F. (2021). Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312812
Bosman, Matthias, et al. "Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312812
Bosman M, Krüger DN, Favere K, Wesley CD, Neutel CHG, Van Asbroeck B, Diebels OR, Faes B, Schenk TJ, Martinet W, De Meyer GRY, Van Craenenbroeck EM, Guns PDF. Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity. Int J Mol Sci. 2021 Nov 26;22(23). doi: 10.3390/ijms222312812. PMID: 34884612.
Copy Download .nbib Format: NLM
Share it on

Int J Mol Sci. 2021 Nov 26;22(23). doi: 10.3390/ijms222312812.

Doxorubicin Impairs Smooth Muscle Cell Contraction: Novel Insights in Vascular Toxicity.

International journal of molecular sciences

Matthias Bosman, Dustin N Krüger, Kasper Favere, Callan D Wesley, Cédric H G Neutel, Birgit Van Asbroeck, Owen R Diebels, Bart Faes, Timen J Schenk, Wim Martinet, Guido R Y De Meyer, Emeline M Van Craenenbroeck, Pieter-Jan D F Guns

Affiliations

  1. Laboratory of Physiopharmacology, Faculty of Medicine and Health Sciences, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.
  2. Research Group Cardiovascular Diseases, University of Antwerp, B-2610 Antwerp, Belgium.
  3. Department of Internal Medicine, Faculty of Medicine and Health Sciences, Ghent University, C. Heymanslaan 10, B-9000 Ghent, Belgium.
  4. Department of Cardiology, Antwerp University Hospital (UZA), Drie Eikenstraat 655, B-2650 Edegem, Belgium.
  5. Research Group MOVANT, Department of Rehabilitation Sciences and Physiotherapy, Faculty of Medicine and Health Sciences, Campus Drie Eiken, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.

PMID: 34884612 DOI: 10.3390/ijms222312812

Abstract

Clinical and animal studies have demonstrated that chemotherapeutic doxorubicin (DOX) increases arterial stiffness, a predictor of cardiovascular risk. Despite consensus about DOX-impaired endothelium-dependent vasodilation as a contributing mechanism, some studies have reported conflicting results on vascular smooth muscle cell (VSMC) function after DOX treatment. The present study aimed to investigate the effects of DOX on VSMC function. To this end, mice received a single injection of 4 mg DOX/kg, or mouse aortic segments were treated ex vivo with 1 μM DOX, followed by vascular reactivity evaluation 16 h later. Phenylephrine (PE)-induced VSMC contraction was decreased after DOX treatment. DOX did not affect the transient PE contraction dependent on Ca

Keywords: arterial stiffness; cardio-oncology; doxorubicin; endothelial dysfunction; non-selective cation channel; vascular smooth muscle cell contraction

Publication Types

Grant support