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Samuel N, Vetkas A, Pancholi A, et al. A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13236127.
Samuel, N., Vetkas, A., Pancholi, A., Sarica, C., Loh, A., Germann, J., Harmsen, I. E., Tasserie, J., Milano, V., Yamamoto, K., Kalia, S. K., Kongkham, P. N., & Lozano, A. M. (2021). A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery. Cancers, 13(23), . https://doi.org/10.3390/cancers13236127
Samuel, Nardin, et al. "A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13236127
Samuel N, Vetkas A, Pancholi A, Sarica C, Loh A, Germann J, Harmsen IE, Tasserie J, Milano V, Yamamoto K, Kalia SK, Kongkham PN, Lozano AM. A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery. Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236127. PMID: 34885236.
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Cancers (Basel). 2021 Dec 05;13(23). doi: 10.3390/cancers13236127.

A Network-Based Approach to Glioma Surgery: Insights from Functional Neurosurgery.

Cancers

Nardin Samuel, Artur Vetkas, Aditya Pancholi, Can Sarica, Aaron Loh, Jurgen Germann, Irene E Harmsen, Jordy Tasserie, Vanessa Milano, Kazuaki Yamamoto, Suneil K Kalia, Paul N Kongkham, Andres M Lozano

Affiliations

  1. Division of Neurosurgery, Toronto Western Hospital, University Health Network, Toronto, ON M5G 2C4, Canada.
  2. Krembil Research Institute, Toronto, ON M5T 2S8, Canada.
  3. Department of Neurology and Neurosurgery, University of Tartu, 50090 Tartu, Estonia.
  4. MD/PhD Program, Faculty of Medicine, University of Toronto, Toronto, ON M5S 1A4, Canada.
  5. Toronto Rehabilitation Institute (KITE), University Health Network, University of Toronto, Toronto, ON M5G 2C4, Canada.
  6. Centre for Advancing Neurotechnological Innovation to Application (CRANIA), University of Toronto, Toronto, ON M5S 1A4, Canada.

PMID: 34885236 DOI: 10.3390/cancers13236127

Abstract

The evaluation and manipulation of structural and functional networks, which has been integral to advancing functional neurosurgery, is beginning to transcend classical subspecialty boundaries. Notably, its application in neuro-oncologic surgery has stimulated an exciting paradigm shift from the traditional localizationist approach, which is lacking in nuance and optimization. This manuscript reviews the existing literature and explores how structural and functional connectivity analyses have been leveraged to revolutionize and individualize pre-operative tumor evaluation and surgical planning. We describe how this novel approach may improve cognitive and neurologic preservation after surgery and attenuate tumor spread. Furthermore, we demonstrate how connectivity analysis combined with neuromodulation techniques can be employed to induce post-operative neuroplasticity and personalize neurorehabilitation. While the landscape of functional neuro-oncology is still evolving and requires further study to encourage more widespread adoption, this functional approach can transform the practice of neuro-oncologic surgery and improve the care and outcomes of patients with intra-axial tumors.

Keywords: connectivity; functional neurosurgery; glioma; networks; neuroplasticity

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