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Transfus Med Rev. 2021 Nov 03; doi: 10.1016/j.tmrv.2021.10.003. Epub 2021 Nov 03.

The Difference in Potential Harms between Whole Blood and Component Blood Transfusion in major Bleeding: A Rapid Systematic Review and Meta-Analysis of RCTs.

Transfusion medicine reviews

Louise J Geneen, Susan J Brunskill, Carolyn Doree, Lise J Estcourt, Laura Green

Affiliations

  1. Systematic Review Initiative, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, UK. Electronic address: [email protected].
  2. Systematic Review Initiative, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, UK.
  3. Systematic Review Initiative, NHS Blood and Transplant, John Radcliffe Hospital, Oxford, UK; Nuffield Division of Clinical Laboratory Sciences, Radcliffe Department of Medicine, University of Oxford, UK; Haematology/Transfusion Medicine, NHS Blood and Transplant, UK.
  4. Haematology/Transfusion Medicine, NHS Blood and Transplant, UK; Barts Health NHS Trust, London, UK; Blizard Institute, Queen Mary, University of London, London, UK.

PMID: 34844826 DOI: 10.1016/j.tmrv.2021.10.003

Abstract

Our aim was to assess whether there is a difference in outcomes of potential "all-cause" harm in the transfusion of whole blood (WB) compared to blood components (BC) for any bleeding patient regardless of age or clinical condition. We searched multiple electronic databases using a pre-defined search strategy from inception to 2

Copyright © 2021. Published by Elsevier Inc.

Keywords: Whole blood; component blood; surgery; transfusion; trauma

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