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Green S, Kiely C, O'Connor E, et al. Differential effects of sex on adaptive responses of skeletal muscle vasodilation to exercise training in type 2 diabetes. J Diabetes Complications. 2021;108098doi: 10.1016/j.jdiacomp.2021.108098.
Green, S., Kiely, C., O'Connor, E., Gildea, N., O'Shea, D., & Egaña, M. (2021). Differential effects of sex on adaptive responses of skeletal muscle vasodilation to exercise training in type 2 diabetes. Journal of diabetes and its complications, 108098. https://doi.org/10.1016/j.jdiacomp.2021.108098
Green, Simon, et al. "Differential effects of sex on adaptive responses of skeletal muscle vasodilation to exercise training in type 2 diabetes." Journal of diabetes and its complications vol. (2021): 108098. doi: https://doi.org/10.1016/j.jdiacomp.2021.108098
Green S, Kiely C, O'Connor E, Gildea N, O'Shea D, Egaña M. Differential effects of sex on adaptive responses of skeletal muscle vasodilation to exercise training in type 2 diabetes. J Diabetes Complications. 2021 Nov 29;108098. doi: 10.1016/j.jdiacomp.2021.108098. Epub 2021 Nov 29. PMID: 34887186.
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J Diabetes Complications. 2021 Nov 29;108098. doi: 10.1016/j.jdiacomp.2021.108098. Epub 2021 Nov 29.

Differential effects of sex on adaptive responses of skeletal muscle vasodilation to exercise training in type 2 diabetes.

Journal of diabetes and its complications

Simon Green, Catherine Kiely, Eamonn O'Connor, Norita Gildea, Donal O'Shea, Mikel Egaña

Affiliations

  1. School of Health Sciences, Western Sydney University, Sydney, Australia; School of Medicine, Western Sydney University, Sydney, Australia.
  2. School of Medicine, Department of Physiology, Trinity College Dublin, Dublin 2, Ireland.
  3. Department of Endocrinology, St. Columcille's Hospital, Dublin, Ireland; Department of Endocrinology and Diabetes Mellitus, St. Vincent's University Hospital, Dublin, Ireland.
  4. School of Medicine, Department of Physiology, Trinity College Dublin, Dublin 2, Ireland. Electronic address: [email protected].

PMID: 34887186 DOI: 10.1016/j.jdiacomp.2021.108098

Abstract

AIMS: We tested the hypotheses that exercise training improves the peak and dynamic responses of leg vascular conductance (LVC) in males and females with type 2 diabetes (T2DM).

METHODS: Forty-one males and females with T2DM were assigned to two training groups and two control groups. Twelve weeks of aerobic/resistance training was performed three times per week, 60-90 min per session. Responses of calf muscle blood flow and systemic arterial pressure during incremental and constant-load (30% maximal voluntary contraction) intermittent plantar-flexion protocols in the supine position were recorded.

RESULTS: Training significantly increased peak LVC in males (4.86 ± 1.88 to 6.06 ± 2.06 ml·min

CONCLUSIONS: These data suggest that training increases the peak vasodilatory response in males and females, whereas the speed of the dynamic response of vasodilation is improved in females but not males.

Copyright © 2021. Published by Elsevier Inc.

Keywords: Diabetes; Muscle contractions; Sex; Training adaptations; Vascular control

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