Display options
Cite
Jones CP, Ferre-D'Amare AR. Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. RNA. 2021;doi: 10.1261/rna.078825.121.
Jones, C. P., & Ferre-D'Amare, A. R. (2021). Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. RNA (New York, N.Y.), . https://doi.org/10.1261/rna.078825.121
Jones, Christopher P, and Ferre-D'Amare, Adrian R. "Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot." RNA (New York, N.Y.) vol. (2021). doi: https://doi.org/10.1261/rna.078825.121
Jones CP, Ferre-D'Amare AR. Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. RNA. 2021 Nov 29; doi: 10.1261/rna.078825.121. Epub 2021 Nov 29. PMID: 34845084.
Copy Download .nbib Format: NLM
Share it on

RNA. 2021 Nov 29; doi: 10.1261/rna.078825.121. Epub 2021 Nov 29.

Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot.

RNA (New York, N.Y.)

Christopher P Jones, Adrian R Ferre-D'Amare

Affiliations

  1. National Institutes of Health, National Heart, Lung and Blood Institute [email protected].
  2. National Institutes of Health, National Heart, Lung and Blood Institute.

PMID: 34845084 DOI: 10.1261/rna.078825.121

Abstract

SARS-CoV-2 produces two long viral protein precursors from one open reading frame using a highly conserved RNA pseudoknot that enhances programmed -1 ribosomal frameshifting. The 1.3 Å-resolution X-ray structure of the pseudoknot reveals three coaxially stacked helices buttressed by idiosyncratic base triples from loop residues. This structure represents a frameshift-stimulating state that must be deformed by the ribosome, and exhibits base-triple-adjacent pockets that could be targeted by future small-molecule therapeutics.

Published by Cold Spring Harbor Laboratory Press for the RNA Society.

Keywords: COVID; RNA; X-ray; base triple; near-atomic resolution

Publication Types