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Harrell CR, Djonov V, Volarevic V. The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells. Histol Histopathol. 2021;18400doi: 10.14670/HH-18-400.
Harrell, C. R., Djonov, V., & Volarevic, V. (2021). The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells. Histology and histopathology, 18400. https://doi.org/10.14670/HH-18-400
Harrell, Carl Randall, et al. "The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells." Histology and histopathology vol. (2021): 18400. doi: https://doi.org/10.14670/HH-18-400
Harrell CR, Djonov V, Volarevic V. The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells. Histol Histopathol. 2021 Nov 30;18400. doi: 10.14670/HH-18-400. Epub 2021 Nov 30. PMID: 34845711.
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Histol Histopathol. 2021 Nov 30;18400. doi: 10.14670/HH-18-400. Epub 2021 Nov 30.

The effects of cigarette smoking and nicotine on the therapeutic potential of mesenchymal stem cells.

Histology and histopathology

Carl Randall Harrell, Valentin Djonov, Vladislav Volarevic

Affiliations

  1. Regenerative Processing Plant, Palm Harbor, Florida, United States of America.
  2. Institute of Anatomy, University of Bern, Bern, Switzerland.
  3. Department of Genetics and Department of Microbiology and Immunology, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. [email protected].

PMID: 34845711 DOI: 10.14670/HH-18-400

Abstract

Due to their immunoregulatory properties and capacity for multi-lineage differentiation, mesenchymal stem cells (MSCs) have been used as new therapeutic agents in regenerative medicine. Numerous lifestyle habits and behavioral risk factors may modulate metabolic and cell growth signaling pathways in MSCs, affecting their phenotype and function. Accordingly, identification of these factors and minimization of their influence on viability and function of transplanted MSCs may greatly contribute to their better therapeutic efficacy. A large number of experimental and clinical studies have demonstrated the detrimental effects of cigarette smoke and nicotine on proliferation, homing, chondrogenic and osteogenic differentiation of MSCs. Cigarette smoke down-regulates expression of chemokine receptors and modulates activity of anti-oxidative enzymes in MSCs, while nicotine impairs synthesis of transcriptional factors that regulate the cell cycle, metabolism, migration, chondrogenesis and osteogenesis. In this review article, we summarize current knowledge about molecular mechanisms that are responsible for cigarette smoke and nicotine-dependent modulation of MSCs' therapeutic potential.

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Grant support