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Gargano F, Schmidt S, Evangelista P, et al. Burn scar regeneration with the "SUFA" (Subcision and Fat Grafting) technique. A prospective clinical study. JPRAS Open. 2018;17:5-8doi: 10.1016/j.jpra.2018.05.001.
Gargano, F., Schmidt, S., Evangelista, P., Robinson-Bostom, L., Harrington, D. T., Rossi, K., Guo, Y., & Liu, P. (2018). Burn scar regeneration with the "SUFA" (Subcision and Fat Grafting) technique. A prospective clinical study. JPRAS open, 175-8. https://doi.org/10.1016/j.jpra.2018.05.001
Gargano, Francesco, et al. "Burn scar regeneration with the "SUFA" (Subcision and Fat Grafting) technique. A prospective clinical study." JPRAS open vol. 17 (2018): 5-8. doi: https://doi.org/10.1016/j.jpra.2018.05.001
Gargano F, Schmidt S, Evangelista P, Robinson-Bostom L, Harrington DT, Rossi K, Guo Y, Liu P. Burn scar regeneration with the "SUFA" (Subcision and Fat Grafting) technique. A prospective clinical study. JPRAS Open. 2018 May 22;17:5-8. doi: 10.1016/j.jpra.2018.05.001. eCollection 2018 Sep. PMID: 32158824; PMCID: PMC7061675.
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JPRAS Open. 2018 May 22;17:5-8. doi: 10.1016/j.jpra.2018.05.001. eCollection 2018 Sep.

Burn scar regeneration with the "SUFA" (Subcision and Fat Grafting) technique. A prospective clinical study.

JPRAS open

Francesco Gargano, Scott Schmidt, Peter Evangelista, Leslie Robinson-Bostom, David T Harrington, Kristie Rossi, Yfan Guo, Paul Liu

Affiliations

  1. The Institute for Advanced Reconstruction at The Plastic Surgery Center, Sycamore Ave., Shrewsbury, NJ, United States.
  2. Division of Plastic Surgery, The Warren Alpert Medical School of Brown University, Richmond St., Providence, RI, United States.
  3. Department of Radiology, The Warren Alpert Medical School of Brown University, Richmond St., Providence, RI, United States.
  4. Department of Dermatology, The Warren Alpert Medical School of Brown University, Richmond St., Providence, RI, United States.
  5. Department of Surgery, The Warren Alpert Medical School of Brown University, Richmond St., Providence, RI, United States.

PMID: 32158824 PMCID: PMC7061675 DOI: 10.1016/j.jpra.2018.05.001

Abstract

BACKGROUND: Treatment of burn scars with traditional surgical techniques is challenging due to recurrent contractures. Fat grafting has been previously used in small clinical series and results are often biased by lack of scientific validating methods. Fat grafting in clinical practice is often evaluated for its filler properties and rarely scientifically validated for its potential in dermal regeneration. Animal studies have shown dermal regeneration with new deposition and reorientation of the collagen fiber. Our study aims to apply the validity of in vitro studies to clinical practice.

METHODS: Our study prospectively evaluated outcomes in 12 patients treated with the "SUFA" technique (Subcision and Fat Grafting) for debilitating contracted burns scars limiting range of motion. Results were evaluated clinically with the Vancouver scale and by range of motion at 1, 3, 6 and 12 months. Dermal regeneration was evaluated by looking at dermis thickening using high definition ultrasound and scar remodeling looking at reorientation and new deposition of collagen fibers with hematoxylin-eosin histology and monoclonal antibodies against collagen type 1 and 3.

RESULTS: Statistically significant clinical improvements in range of motion of the affected joints was observed (

CONCLUSIONS: Our results present the first clinical scientific evidence of dermal regeneration in fat grafting. Using monoclonal antibodies and high definition ultrasounds, we demonstrate the first evidence of dermis regeneration in a clinical scenario.

© 2018 The Authors.

Keywords: De-epithelialized flap; Decubitus ulcers; Pressure sore protocol; Pressure sore treatment; Pressure ulcer; Prevention of pressure ulcers

References

  1. Plast Reconstr Surg. 2014 Jun;133(6):1369-77 - PubMed
  2. J Med Ultrasound. 2009;17(1):25-30 - PubMed
  3. J Plast Reconstr Aesthet Surg. 2012 Feb;65(2):219-27 - PubMed
  4. Plast Reconstr Surg. 2013 Nov;132(5):1280-90 - PubMed
  5. J Trauma. 1974 May;14(5):389-95 - PubMed
  6. J Burn Care Res. 2013 Mar-Apr;34(2):219-26 - PubMed

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