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Han H, Hensch L, Tubman VN. Indications for transfusion in the management of sickle cell disease. Hematology Am Soc Hematol Educ Program. 2021;2021(1):696-703doi: 10.1182/hematology.2021000307.
Han, H., Hensch, L., & Tubman, V. N. (2021). Indications for transfusion in the management of sickle cell disease. Hematology. American Society of Hematology. Education Program, 2021(1), 696-703. https://doi.org/10.1182/hematology.2021000307
Han, Hyojeong, et al. "Indications for transfusion in the management of sickle cell disease." Hematology. American Society of Hematology. Education Program vol. 2021,1 (2021): 696-703. doi: https://doi.org/10.1182/hematology.2021000307
Han H, Hensch L, Tubman VN. Indications for transfusion in the management of sickle cell disease. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):696-703. doi: 10.1182/hematology.2021000307. PMID: 34889416.
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Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):696-703. doi: 10.1182/hematology.2021000307.

Indications for transfusion in the management of sickle cell disease.

Hematology. American Society of Hematology. Education Program

Hyojeong Han, Lisa Hensch, Venée N Tubman

Affiliations

  1. Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX.
  2. Department of Pediatrics, Baylor College of Medicine, Houston, TX.
  3. Division of Transfusion Medicine and Coagulation, Texas Children's Hospital, Houston, TX.
  4. Department of Pathology and Immunology and Anesthesiology, Baylor College of Medicine, Houston, TX.

PMID: 34889416 DOI: 10.1182/hematology.2021000307

Abstract

The transfusion of red blood cells (RBCs) is a crucial treatment for sickle cell disease (SCD). While often beneficial, the frequent use of transfusions is associated with numerous complications. Transfusions should be offered with specific guidelines in mind. Here we present updates to the indications for transfusion of RBCs in SCD. We review recent publications and include expert perspectives from hematology and transfusion medicine. For some clinical indications, such as ischemic stroke, the role of transfusion has been well studied and can be applied almost universally. For many other clinical scenarios, the use of transfusion therapy has less conclusive data and therefore must be tailored to individual needs. We highlight the roles of RBC transfusions in preventing or mitigating neurological disease, in reducing perioperative complications, in managing acute chest syndrome, and in optimizing pregnancy outcomes in SCD. We further highlight various transfusion techniques and when each might be considered. Potential complications of transfusion are also briefly discussed.

Copyright © 2021 by The American Society of Hematology.

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