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Howard B, Bascom CC, Hu P, et al. Aging Associated Changes in the Adult Human Skin Microbiome and the Host Factors That Affect Skin Microbiome Composition. J Invest Dermatol. 2021;doi: 10.1016/j.jid.2021.11.029.
Howard, B., Bascom, C. C., Hu, P., Binder, R. L., Fadayel, G., Huggins, T. G., Jarrold, B. B., Osborne, R., Rocchetta, H. L., Swift, D., Tiesman, J. P., Song, Y., Wang, Y., Wehmeyer, K., Kimball, A. B., & Isfort, R. J. (2021). Aging Associated Changes in the Adult Human Skin Microbiome and the Host Factors That Affect Skin Microbiome Composition. The Journal of investigative dermatology, . https://doi.org/10.1016/j.jid.2021.11.029
Howard, Brian, et al. "Aging Associated Changes in the Adult Human Skin Microbiome and the Host Factors That Affect Skin Microbiome Composition." The Journal of investigative dermatology vol. (2021). doi: https://doi.org/10.1016/j.jid.2021.11.029
Howard B, Bascom CC, Hu P, Binder RL, Fadayel G, Huggins TG, Jarrold BB, Osborne R, Rocchetta HL, Swift D, Tiesman JP, Song Y, Wang Y, Wehmeyer K, Kimball AB, Isfort RJ. Aging Associated Changes in the Adult Human Skin Microbiome and the Host Factors That Affect Skin Microbiome Composition. J Invest Dermatol. 2021 Dec 07; doi: 10.1016/j.jid.2021.11.029. Epub 2021 Dec 07. PMID: 34890626.
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J Invest Dermatol. 2021 Dec 07; doi: 10.1016/j.jid.2021.11.029. Epub 2021 Dec 07.

Aging Associated Changes in the Adult Human Skin Microbiome and the Host Factors That Affect Skin Microbiome Composition.

The Journal of investigative dermatology

Brian Howard, Charles C Bascom, Ping Hu, Robert L Binder, Gina Fadayel, Tom G Huggins, Bradley B Jarrold, Rosemarie Osborne, Heather L Rocchetta, Dionne Swift, Jay P Tiesman, Yuli Song, Yu Wang, Kenneth Wehmeyer, Alexa B Kimball, Robert J Isfort

Affiliations

  1. The Procter & Gamble Company, Cincinnati, OH USA.
  2. The Procter & Gamble Company, Cincinnati, OH USA. Electronic address: [email protected].
  3. Harvard Medical School, Boston, MA USA.

PMID: 34890626 DOI: 10.1016/j.jid.2021.11.029

Abstract

Understanding changes in the skin microbiome and their relationship to host skin factors during aging remains largely unknown. To better understand this phenomenon, we collected samples for metagenomic and host skin factor analyses from forearm, buttock, and facial skin from 158 Caucasian females at 20-24, 30-34, 40-44, 50-54, 60-64, and 70-74 years of age. Metagenomics analysis was performed using 16S rRNA gene sequencing, while host sebocyte gland area, skin lipids, natural moisturizing factors (NMFs) and anti-microbial peptides (AMPs) measurements were also performed. These analyses demonstrated that skin bacterial diversity increased at all the skin sites with increasing age. Of the bacterial genera with average relative abundance of >1%, only Lactobacillus and Cutibacterium demonstrated a significant change (decrease) in abundance at all sampled skin sites with increasing age. Additional bacterial genera demonstrated significant age and site-specific changes in abundance. Analysis of sebocyte area, NMFs, lipids and AMPs demonstrated an age-related decrease in sebocyte area and increases in NMFs/AMPs/skin lipids, all which correlated with changes in specific bacterial genera. In conclusion, the human skin microbiome undergoes age-associated alterations that may reflect underlying age-related changes in cutaneous biology.

Copyright © 2021. Published by Elsevier Inc.

Keywords: antimicrobial peptides; lipids; microbiome; natural moisturizing factors; sebum; skin

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