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Martins-Melo FR, Castro MC, Werneck GL, et al. Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis. Trans R Soc Trop Med Hyg. 2021;doi: 10.1093/trstmh/trab183.
Martins-Melo, F. R., Castro, M. C., Werneck, G. L., & Heukelbach, J. (2021). Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis. Transactions of the Royal Society of Tropical Medicine and Hygiene, . https://doi.org/10.1093/trstmh/trab183
Martins-Melo, Francisco Rogerlândio, et al. "Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis." Transactions of the Royal Society of Tropical Medicine and Hygiene vol. (2021). doi: https://doi.org/10.1093/trstmh/trab183
Martins-Melo FR, Castro MC, Werneck GL, Heukelbach J. Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis. Trans R Soc Trop Med Hyg. 2021 Dec 09; doi: 10.1093/trstmh/trab183. Epub 2021 Dec 09. PMID: 34891173.
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Trans R Soc Trop Med Hyg. 2021 Dec 09; doi: 10.1093/trstmh/trab183. Epub 2021 Dec 09.

Deaths related to Chagas disease and HIV/AIDS coinfection in Brazil: a nationwide population-based analysis.

Transactions of the Royal Society of Tropical Medicine and Hygiene

Francisco Rogerlândio Martins-Melo, Marcia C Castro, Guilherme Loureiro Werneck, Jorg Heukelbach

Affiliations

  1. Federal Institute of Education, Science and Technology of Ceará, Fortaleza 60040-531, Ceará, Brazil.
  2. Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston 02115, Massachusetts, USA.
  3. Institute of Studies in Public Health, Federal University of Rio de Janeiro, Rio de Janeiro 21941-598, Rio de Janeiro, Brazil.
  4. Department of Epidemiology, Social Medicine Institute, State University of Rio de Janeiro, Rio de Janeiro 20550-013, Rio de Janeiro, Brazil.
  5. Postgraduate Program in Public Health, School of Medicine, Federal University of Ceará, Fortaleza 60430-140, Brazil.

PMID: 34891173 DOI: 10.1093/trstmh/trab183

Abstract

BACKGROUND: Trypanosoma cruzi/HIV coinfection has been described as a relevant clinical event and an emerging public health problem. Here, we describe the epidemiological patterns of deaths related to Chagas disease and HIV/AIDS coinfection in Brazil from 2000 to 2019.

METHODS: We performed a nationwide population-based study using mortality data obtained from the Brazilian Mortality Information System. We included all deaths recorded in Brazil from 2000 to 2019 in which Chagas disease and HIV/AIDS were mentioned on the same death certificate, either as underlying or as associated causes of death.

RESULTS: Chagas disease and HIV/AIDS were mentioned on 196/22 663 092 death certificates. HIV/AIDS was the underlying cause in 58.2% (114/196) of deaths and Chagas disease in 33.2% (65/196). The average annual mortality rate was 0.05 deaths/1 000 000 inhabitants (95% CI 0.03 to 0.09). The highest death rates were found among males, those aged 60-69 y, Afro-Brazilians, those with 1-3 y of schooling/study and residents in Chagas disease-endemic regions/states. Respiratory, infectious/parasitic and cardiovascular diseases/disorders were the associated causes of death most commonly mentioned.

CONCLUSIONS: Mortality due to Chagas disease and HIV/AIDS coinfection may be largely underestimated in Brazil. Our data further reinforce the importance of screening for T. cruzi infection in HIV-infected patients from Chagas disease-endemic areas. Appropriate clinical management should be ensured for Chagas disease and HIV coinfected patients.

© The Author(s) 2021. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene.

Keywords: AIDS, Brazil; Chagas disease; HIV; coinfection; mortality

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