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Caron M, Gely L, Garvis S, et al. Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in . Life Sci Alliance. 2021;5(3)doi: 10.26508/lsa.202101140.
Caron, M., Gely, L., Garvis, S., Adrait, A., Couté, Y., Palladino, F., & Fabrizio, P. (2022). Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in . Life science alliance, 5(3), . https://doi.org/10.26508/lsa.202101140
Caron, Matthieu, et al. "Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in ." Life science alliance vol. 5,3 (2022). doi: https://doi.org/10.26508/lsa.202101140
Caron M, Gely L, Garvis S, Adrait A, Couté Y, Palladino F, Fabrizio P. Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in . Life Sci Alliance. 2021 Dec 10;5(3). doi: 10.26508/lsa.202101140. Print 2022 Mar. PMID: 34893559.
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Life Sci Alliance. 2021 Dec 10;5(3). doi: 10.26508/lsa.202101140. Print 2022 Mar.

Loss of SET1/COMPASS methyltransferase activity reduces lifespan and fertility in .

Life science alliance

Matthieu Caron, Loïc Gely, Steven Garvis, Annie Adrait, Yohann Couté, Francesca Palladino, Paola Fabrizio

Affiliations

  1. Laboratory of Biology and Modelling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR5239, INSERM U1210, Université de Lyon, Lyon, France.
  2. University of Grenoble Alpes, INSERM, CEA, UMR BioSanté U1292, CNRS, CEA, FR2048, Grenoble, France.
  3. Laboratory of Biology and Modelling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR5239, INSERM U1210, Université de Lyon, Lyon, France [email protected].
  4. Laboratory of Biology and Modelling of the Cell, Ecole Normale Supérieure de Lyon, CNRS UMR5239, INSERM U1210, Université de Lyon, Lyon, France [email protected].

PMID: 34893559 DOI: 10.26508/lsa.202101140

Abstract

Changes in histone post-translational modifications are associated with aging through poorly defined mechanisms. Histone 3 lysine 4 (H3K4) methylation at promoters is deposited by SET1 family methyltransferases acting within conserved multiprotein complexes known as COMPASS. Previous work yielded conflicting results about the requirement for H3K4 methylation during aging. Here, we reassessed the role of SET1/COMPASS-dependent H3K4 methylation in

© 2021 Caron et al.

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