Display options
Cite
González KA, Tarraf W, Wallace DM, et al. Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos. Sleep. 2021;44(12)doi: 10.1093/sleep/zsab181.
González, K. A., Tarraf, W., Wallace, D. M., Stickel, A. M., Schneiderman, N., Redline, S., Patel, S. R., Gallo, L. C., Mossavar-Rahmani, Y., Daviglus, M. L., Zee, P. C., Talavera, G. A., Sotres-Alvarez, D., González, H. M., & Ramos, A. (2021). Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos. Sleep, 44(12), . https://doi.org/10.1093/sleep/zsab181
González, Kevin A, et al. "Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos." Sleep vol. 44,12 (2021). doi: https://doi.org/10.1093/sleep/zsab181
González KA, Tarraf W, Wallace DM, Stickel AM, Schneiderman N, Redline S, Patel SR, Gallo LC, Mossavar-Rahmani Y, Daviglus ML, Zee PC, Talavera GA, Sotres-Alvarez D, González HM, Ramos A. Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos. Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab181. PMID: 34272952; PMCID: PMC8664595.
Copy Download .nbib Format: NLM
Share it on

Sleep. 2021 Dec 10;44(12). doi: 10.1093/sleep/zsab181.

Phenotypes of obstructive sleep apnea in the Hispanic Community Health Study/Study of Latinos.

Sleep

Kevin A González, Wassim Tarraf, Douglas M Wallace, Ariana M Stickel, Neil Schneiderman, Susan Redline, Sanjay R Patel, Linda C Gallo, Yasmin Mossavar-Rahmani, Martha L Daviglus, Phyllis C Zee, Gregory A Talavera, Daniela Sotres-Alvarez, Hector M González, Alberto Ramos

Affiliations

  1. Department of Neurosciences and Shiley-Marcos Alzheimer's Disease Research Center, University of California San Diego School of Medicine, San Diego, CA, USA.
  2. Department of Healthcare Sciences and Institute of Gerontology, Wayne State University, Detroit, MI, USA.
  3. Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
  4. Department of Psychology, University of Miami, Miami, FL, USA.
  5. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  6. Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
  7. Department of Psychology and South Bay Latino Research Center, San Diego State University, San Diego, CA, USA.
  8. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
  9. Institute for Minority Health Research, University of Illinois at Chicago College of Medicine, Chicago, IL, USA.
  10. Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  11. Graduate School of Public Health, San Diego State University, San Diego, CA, USA.
  12. Department of Biostatistics, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA.

PMID: 34272952 PMCID: PMC8664595 DOI: 10.1093/sleep/zsab181

Abstract

STUDY OBJECTIVES: Recent work on US Whites from clinical samples used obstructive sleep apnea (OSA) symptoms to generate phenotypes for individuals with moderate-severe OSA which suggested 3 to 5 symptom classes. However, it is unknown whether similar classes generalize to diverse Hispanics/Latino adults. Therefore, we sought to fill this gap by empirically deriving sleep phenotypes among a large sample of diverse Hispanics/Latinos.

METHODS: We used data from The Hispanic Community Health Study/Study of Latinos (HCHS/SOL; 2008-2011), a prospective cohort study designed using a multisite multistage probability sample of adults 18-74 years old. The subpopulation of interest included participants with moderate-severe OSA symptoms (≥15 respiratory event index (REI) events per hour; n = 1,605). We performed latent class analysis for complex survey data using 15 common OSA symptoms (e.g. Epworth Sleepiness Scale) and 4 comorbidities to identify phenotype classes.

RESULTS: Average age was 52.4 ± 13.9 years and 34.0% were female. Mean REI was 33.8 ± 22.5 events per hour. Fit statistics and clinical significance suggested that a three-class solution provided the best fit to the data. The three phenotypes were: (1) Minimally Symptomatic (47.7%), (2) Excessive sleepiness (37.1%), and (3) Disturbed Sleep (15.2%). Sensitivity models were consistent with the main proposed solution.

CONCLUSIONS: Derived sleep phenotypes among diverse Hispanic/Latinos were consistent with recent findings from the Sleep Apnea Global Interdisciplinary Consortium, but we found notable differences in class prevalence relative to Whites. Further research is needed to link derived sleep phenotypes to health comorbidities in diverse populations.

© Sleep Research Society 2021. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please email: [email protected].

Keywords: Hispanics/Latinos; latent class analysis; obstructive sleep apnea; sleep phenotypes

References

  1. Med Care. 1996 Mar;34(3):220-33 - PubMed
  2. Psychol Health. 2018 Jun;33(6):724-745 - PubMed
  3. Am J Public Health. 2001 Aug;91(8):1254-7 - PubMed
  4. Otolaryngol Head Neck Surg. 2005 Feb;132(2):255-62 - PubMed
  5. JAMA. 2012 Nov 7;308(17):1775-84 - PubMed
  6. Sleep. 2018 Mar 1;41(3): - PubMed
  7. Ethn Dis. 2008 Winter;18(1):93-7 - PubMed
  8. JAMA. 2012 May 23;307(20):2169-76 - PubMed
  9. Sleep Med. 2020 Oct;74:92-98 - PubMed
  10. Hypertension. 2008 Nov;52(5):818-27 - PubMed
  11. Circulation. 1996 Dec 1;94(11):2850-5 - PubMed
  12. Med Care Res Rev. 2000;57 Suppl 1:36-54 - PubMed
  13. Prev Med. 2016 Jun;87:144-150 - PubMed
  14. Chest. 2005 May;127(5):1674-9 - PubMed
  15. Ann Epidemiol. 2010 Aug;20(8):642-9 - PubMed
  16. Sleep Med Rev. 2007 Apr;11(2):135-42 - PubMed
  17. Rand Health Q. 2017 Jan 1;6(4):11 - PubMed
  18. Sleep Med. 2003 Mar;4(2):101-19 - PubMed
  19. Sleep. 2006 Jan;29(1):85-93 - PubMed
  20. Am J Respir Crit Care Med. 2014 Feb 1;189(3):335-44 - PubMed
  21. Sleep. 2015 Oct 01;38(10):1515-22 - PubMed
  22. Sleep. 2011 Aug 01;34(8):1021-31 - PubMed
  23. Eur Respir J. 2016 Jan;47(1):194-202 - PubMed
  24. Hum Psychopharmacol. 2008 Oct;23(7):571-85 - PubMed
  25. Am J Respir Crit Care Med. 2017 Oct 15;196(8):993-1003 - PubMed
  26. Aust N Z J Psychiatry. 2005 Jul;39(7):583-90 - PubMed
  27. Eur Respir J. 2005 Aug;26(2):319-38 - PubMed
  28. Semin Immunopathol. 2009 Jun;31(1):113-25 - PubMed
  29. Am J Epidemiol. 2004 Sep 15;160(6):521-30 - PubMed
  30. J Health Soc Behav. 2010 Dec;51(4):440-57 - PubMed
  31. Eur Arch Otorhinolaryngol. 2013 Mar;270(3):1131-6 - PubMed
  32. PLoS Med. 2004 Dec;1(3):e62 - PubMed
  33. Am J Respir Crit Care Med. 2021 May 1;203(9):1173-1182 - PubMed
  34. J Gen Intern Med. 2001 Apr;16(4):266-75 - PubMed
  35. J Clin Psychiatry. 2005 Oct;66(10):1254-69 - PubMed
  36. J Clin Sleep Med. 2018 Mar 15;14(3):437-443 - PubMed
  37. Circulation. 2010 Jul 27;122(4):352-60 - PubMed
  38. PLoS One. 2009 Sep 22;4(9):e7107 - PubMed
  39. Psychol Assess. 2017 Apr;29(4):372-381 - PubMed
  40. Sleep Med. 2019 May;57:100-106 - PubMed
  41. Chest. 1988 Jul;94(1):9-14 - PubMed
  42. Am J Respir Crit Care Med. 2019 Aug 15;200(4):493-506 - PubMed
  43. Eur Respir J. 2014 Dec;44(6):1600-7 - PubMed
  44. J Neurosci Res. 2015 Dec;93(12):1778-94 - PubMed
  45. Sleep Med Rev. 2017 Aug;34:70-81 - PubMed
  46. Am J Epidemiol. 2006 Apr 15;163(8):754-61 - PubMed
  47. Diabetes Care. 2019 Jan;42(Suppl 1):S13-S28 - PubMed
  48. Sleep. 2019 Mar 1;42(3): - PubMed
  49. Sleep. 2018 Mar 1;41(3): - PubMed
  50. Neurology. 2015 Jan 27;84(4):391-8 - PubMed
  51. Sleep. 2014 Feb 01;37(2):309-17 - PubMed
  52. Prog Cardiovasc Dis. 2014 Nov-Dec;57(3):230-6 - PubMed
  53. Psychosom Med. 2002 Mar-Apr;64(2):337-44 - PubMed
  54. Ethn Dis. 2012 Winter;22(1):38-44 - PubMed
  55. J Clin Sleep Med. 2010 Apr 15;6(2):176-83 - PubMed

Publication Types

Grant support