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Am J Dermatopathol. 2022 Jan 01;44(1):62-65. doi: 10.1097/DAD.0000000000002014.

Primary Cutaneous Gamma-Delta T-Cell Lymphoma Mimicking anaplastic lymphoma kinase-1-Negative Anaplastic Large Cell Lymphoma: A Case Report.

The American Journal of dermatopathology

Hany Meawad, Joo Y Song, Matthew L Ulrickson, Dennis D Weisenburger

Affiliations

  1. Department of Pathology, City of Hope Comprehensive Cancer Center, Duarte, CA; and.
  2. Department of Hematology, Stem Cell Transplant and Cellular Therapy, Banner MD Anderson Cancer Center, Gilbert, AZ.

PMID: 34889814 DOI: 10.1097/DAD.0000000000002014

Abstract

ABSTRACT: Primary cutaneous gamma-delta T-cell lymphoma is a rare and aggressive neoplasm, representing less than 1% of all cutaneous T-cell lymphomas. In this article, we report the case of a 49-year-old woman who presented with a history of generalized skin rash and a recent mass on the left upper extremity, as well as right inguinal soft tissue swelling and splenomegaly. Histologic examination of the mass revealed a diffuse subcutaneous infiltrate of large anaplastic and CD30-positive lymphoid cells with rimming of the adipocytes. This case demonstrates unusual cytologic features in primary cutaneous gamma-delta T-cell lymphoma that mimic the features of anaplastic lymphoma kinase-1-negative anaplastic large-cell lymphoma.

Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

Conflict of interest statement

The authors declare no conflicts of interest.

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