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Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2021 Dec;29(6):1972-1976. doi: 10.19746/j.cnki.issn.1009-2137.2021.06.049.

[Research Advance of the Roles of N6-methyladenosine in the Regulation of Hematopoiesis--Review].

Zhongguo shi yan xue ye xue za zhi

[Article in Chinese]
Ni-Ni Wang, Ya-Pu Li, Tao Cheng, Hui Cheng

Affiliations

  1. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College.
  2. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College National Clinical Research Center for Blood Diseases; Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.E-mail: [email protected].
  3. State Key Laboratory of Experimental Hematology, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College National Clinical Research Center for Blood Diseases; Center for Stem Cell Medicine, Chinese Academy of Medical Sciences, Department of Stem Cell & Regenerative Medicine, Peking Union Medical College, Tianjin 300020, China.E-mail: [email protected].

PMID: 34893144 DOI: 10.19746/j.cnki.issn.1009-2137.2021.06.049

Abstract

There are more than 150 types of chemical modifications in RNA, mainly methylation, which are widely distributed in all kinds of RNA, including messenger RNA, transfer RNA, ribosomal RNA, non-coding small RNA and long non-coding RNA. In recent years, the identification of RNA methylation modification enzymes and the development of high-throughput sequencing technology at transcriptome level laid a foundation for revealing the expression and function of genes regulated by chemical modification of RNA. In this review, the most recent advances of RNA methylation, especially N6-methyladenosine (m

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