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Houck EL, Papich MG, Delk KW. Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration. J Vet Pharmacol Ther. 2021;doi: 10.1111/jvp.13036.
Houck, E. L., Papich, M. G., & Delk, K. W. (2021). Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration. Journal of veterinary pharmacology and therapeutics, . https://doi.org/10.1111/jvp.13036
Houck, Emma L, et al. "Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration." Journal of veterinary pharmacology and therapeutics vol. (2021). doi: https://doi.org/10.1111/jvp.13036
Houck EL, Papich MG, Delk KW. Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration. J Vet Pharmacol Ther. 2021 Dec 11; doi: 10.1111/jvp.13036. Epub 2021 Dec 11. PMID: 34894412.
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J Vet Pharmacol Ther. 2021 Dec 11; doi: 10.1111/jvp.13036. Epub 2021 Dec 11.

Phenylbutazone pharmacokinetics in southern white rhinoceros (Ceratotherium simum simum) after oral administration.

Journal of veterinary pharmacology and therapeutics

Emma L Houck, Mark G Papich, Katie W Delk

Affiliations

  1. North Carolina State University College of Veterinary Medicine, Raleigh, North Carolina, USA.
  2. North Carolina Zoo, Asheboro, North Carolina, USA.

PMID: 34894412 DOI: 10.1111/jvp.13036

Abstract

Southern white rhinoceros (Ceratotherium simum simum) frequently develop painful conditions, such as traumatic injuries or osteoarthritis, necessitating the administration of pain-relieving medications. One of the preferred treatments is the nonsteroidal anti-inflammatory drug phenylbutazone because of the availability of oral formulations and the familiarity of its use in horses. For the main study, a single oral dose of phenylbutazone at 2 mg/kg was administered to healthy adult rhinoceros (n = 33) housed at six North American zoological institutions. Each rhinoceros had up to four blood samples collected under voluntary behavioural restraint at up to four predetermined time points (0, 1, 1.5, 2, 3, 4, 6, 8, 10, 24, 30 and 48 h). Drug analysis was performed by high-performance liquid chromatography. The population pharmacokinetic parameters were calculated with nonlinear mixed-effects modelling, and analysis showed a peak concentration (C

© 2021 John Wiley & Sons Ltd.

Keywords: Ceratotherium simum ; analgesia; pharmacokinetics; phenylbutazone; rhinoceros

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