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Augugliaro M, Marvaso G, Cambria R, et al. Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience. Phys Med. 2021;92:62-68doi: 10.1016/j.ejmp.2021.11.005.
Augugliaro, M., Marvaso, G., Cambria, R., Pepa, M., Bagnardi, V., Frassoni, S., Pansini, F., Patricia Rojas, D., Colombo, F., Iuliana Fodor, C., Musi, G., Petralia, G., De Cobelli, O., Cattani, F., Orecchia, R., Zerini, D., & Alicja Jereczek-Fossa, B. (2021). Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience. Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 9262-68. https://doi.org/10.1016/j.ejmp.2021.11.005
Augugliaro, Matteo, et al. "Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience." Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) vol. 92 (2021): 62-68. doi: https://doi.org/10.1016/j.ejmp.2021.11.005
Augugliaro M, Marvaso G, Cambria R, Pepa M, Bagnardi V, Frassoni S, Pansini F, Patricia Rojas D, Colombo F, Iuliana Fodor C, Musi G, Petralia G, De Cobelli O, Cattani F, Orecchia R, Zerini D, Alicja Jereczek-Fossa B. Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience. Phys Med. 2021 Dec 03;92:62-68. doi: 10.1016/j.ejmp.2021.11.005. Epub 2021 Dec 03. PMID: 34871888.
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Phys Med. 2021 Dec 03;92:62-68. doi: 10.1016/j.ejmp.2021.11.005. Epub 2021 Dec 03.

Finding safe dose-volume constraints for re-irradiation with SBRT of patients with prostate cancer relapse: The IEO experience.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

Matteo Augugliaro, Giulia Marvaso, Raffaella Cambria, Matteo Pepa, Vincenzo Bagnardi, Samuele Frassoni, Floriana Pansini, Damaris Patricia Rojas, Francesca Colombo, Cristiana Iuliana Fodor, Gennaro Musi, Giuseppe Petralia, Ottavio De Cobelli, Federica Cattani, Roberto Orecchia, Dario Zerini, Barbara Alicja Jereczek-Fossa

Affiliations

  1. Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
  2. Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy; Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy.
  3. Unit of Medical Physics, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
  4. Division of Radiation Oncology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy. Electronic address: [email protected].
  5. Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Piazza dell'Ateneo Nuovo, 1, 20126 Milan, Italy.
  6. Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy; Division of Urology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
  7. Department of Oncology and Hemato-oncology, University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy; Division of Radiology, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.
  8. Scientific Direction, IEO, European Institute of Oncology IRCCS, Via Ripamonti 435, 20141 Milan, Italy.

PMID: 34871888 DOI: 10.1016/j.ejmp.2021.11.005

Abstract

AIM: The primary aim of this study is to provide preliminary indications for safe constraints of rectum and bladder in patients re-irradiated with stereotactic body RT (SBRT).

METHODS: Data from patients treated for prostate cancer (PCa) and intraprostatic relapse, from 1998 to 2016, were retrospectively collected. First RT course was delivered with 3D conformal RT techniques, SBRT or volumetric modulated arc therapy (VMAT). All patients underwent re-irradiation with SBRT with heavy hypofractionated schedules. Cumulative dose-volume values to organs at risk (OARs) were computed and possible correlation with developed toxicities was investigated.

RESULTS: Twenty-six patients were included. Median age at re-irradiation was 75 years, mean interval between the two RT courses was 5.6 years and the median follow-up was 47.7 months (13.4-114.3 months). After re-irradiation, acute and late G ≥ 2 GU toxicity events were reported in 3 (12%) and 10 (38%) patients, respectively, while late G ≥ 2 GI events were reported in 4 (15%) patients. No acute G ≥ 2 GI side effects were registered. Patients receiving an equivalent uniform dose of the two RT treatments < 131 Gy appeared to be at higher risk of progression (4-yr b-PFS: 19% vs 33%, p = 0.145). Cumulative re-irradiation constraints that appear to be safe are D

CONCLUSION: Preliminary re-irradiation constraints for bladder and rectum have been reported. Our preliminary investigation may serve to clear some grey areas of PCa re-irradiation.

Copyright © 2021 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved.

Keywords: Dosimetric constraints; Re-irradiation; Recurrent prostate cancer; Salvage external beam radiotherapy

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