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Torres-Machorro AL. Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222312855.
Torres-Machorro, A. L. (2021). Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222312855
Torres-Machorro, Ana Lilia. "Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222312855
Torres-Machorro AL. Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors. Int J Mol Sci. 2021 Nov 28;22(23). doi: 10.3390/ijms222312855. PMID: 34884664; PMCID: PMC8657788.
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Int J Mol Sci. 2021 Nov 28;22(23). doi: 10.3390/ijms222312855.

Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.

International journal of molecular sciences

Ana Lilia Torres-Machorro

Affiliations

  1. Laboratorio de Biología Celular, Departamento de Investigación en Fibrosis Pulmonar, Instituto Nacional de Enfermedades Respiratorias "Ismael Cosío Villegas", Tlalpan, Mexico City 14080, Mexico.

PMID: 34884664 PMCID: PMC8657788 DOI: 10.3390/ijms222312855

Abstract

The basic helix-loop-helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best known bHLH TFs are the E-protein homodimers and heterodimers with the tissue-specific TFs or ID proteins. These cooperative and dynamic interactions result in a complex transcriptional network that helps define the cell's fate. Here, the reported dimeric interactions of 67 vertebrate bHLH TFs with other family members are summarized in tables, including specifications of the experimental techniques that defined the dimers. The compilation of these extensive data underscores homodimers of tissue-specific bHLH TFs as a central part of the bHLH regulatory network, with relevant positive and negative transcriptional regulatory roles. Furthermore, some sequence-specific TFs can also form transcriptionally inactive heterodimers with each other. The function, classification, and developmental role for all vertebrate bHLH TFs in four major classes are detailed.

Keywords: Class II bHLH transcription factors; DNA binding; E-proteins; ID proteins; protein–protein interactions; sequence-specific transcription factors; transcriptional regulation

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