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Lyapina I, Ivanov V, Fesenko I. Peptidome: Chaos or Inevitability. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222313128.
Lyapina, I., Ivanov, V., & Fesenko, I. (2021). Peptidome: Chaos or Inevitability. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222313128
Lyapina, Irina, et al. "Peptidome: Chaos or Inevitability." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222313128
Lyapina I, Ivanov V, Fesenko I. Peptidome: Chaos or Inevitability. Int J Mol Sci. 2021 Dec 04;22(23). doi: 10.3390/ijms222313128. PMID: 34884929; PMCID: PMC8658490.
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Int J Mol Sci. 2021 Dec 04;22(23). doi: 10.3390/ijms222313128.

Peptidome: Chaos or Inevitability.

International journal of molecular sciences

Irina Lyapina, Vadim Ivanov, Igor Fesenko

Affiliations

  1. Department of Functional Genomics and Proteomics of Plants, Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences, 117997 Moscow, Russia.

PMID: 34884929 PMCID: PMC8658490 DOI: 10.3390/ijms222313128

Abstract

Thousands of naturally occurring peptides differing in their origin, abundance and possible functions have been identified in the tissue and biological fluids of vertebrates, insects, fungi, plants and bacteria. These peptide pools are referred to as intracellular or extracellular peptidomes, and besides a small proportion of well-characterized peptide hormones and defense peptides, are poorly characterized. However, a growing body of evidence suggests that unknown bioactive peptides are hidden in the peptidomes of different organisms. In this review, we present a comprehensive overview of the mechanisms of generation and properties of peptidomes across different organisms. Based on their origin, we propose three large peptide groups-functional protein "degradome", small open reading frame (smORF)-encoded peptides (smORFome) and specific precursor-derived peptides. The composition of peptide pools identified by mass-spectrometry analysis in human cells, plants, yeast and bacteria is compared and discussed. The functions of different peptide groups, for example the role of the "degradome" in promoting defense signaling, are also considered.

Keywords: biologically active peptides; peptidome generation; peptidomes; protein precursors

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