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Bisconti M, Simon JF, Grassi S, et al. Influence of Risk Factors for Male Infertility on Sperm Protein Composition. Int J Mol Sci. 2021;22(23)doi: 10.3390/ijms222313164.
Bisconti, M., Simon, J. F., Grassi, S., Leroy, B., Martinet, B., Arcolia, V., Isachenko, V., & Hennebert, E. (2021). Influence of Risk Factors for Male Infertility on Sperm Protein Composition. International journal of molecular sciences, 22(23), . https://doi.org/10.3390/ijms222313164
Bisconti, Marie, et al. "Influence of Risk Factors for Male Infertility on Sperm Protein Composition." International journal of molecular sciences vol. 22,23 (2021). doi: https://doi.org/10.3390/ijms222313164
Bisconti M, Simon JF, Grassi S, Leroy B, Martinet B, Arcolia V, Isachenko V, Hennebert E. Influence of Risk Factors for Male Infertility on Sperm Protein Composition. Int J Mol Sci. 2021 Dec 06;22(23). doi: 10.3390/ijms222313164. PMID: 34884971; PMCID: PMC8658491.
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Int J Mol Sci. 2021 Dec 06;22(23). doi: 10.3390/ijms222313164.

Influence of Risk Factors for Male Infertility on Sperm Protein Composition.

International journal of molecular sciences

Marie Bisconti, Jean-François Simon, Sarah Grassi, Baptiste Leroy, Baptiste Martinet, Vanessa Arcolia, Vladimir Isachenko, Elise Hennebert

Affiliations

  1. Laboratory of Cell Biology, Research Institute for Biosciences, University of Mons, Place du Parc 20, 7000 Mons, Belgium.
  2. Fertility Clinic, CHU Ambroise Paré Hospital, Boulevard Kennedy 2, 7000 Mons, Belgium.
  3. Laboratory of Proteomics and Microbiology, CISMa, Research Institute for Biosciences, University of Mons, 7000 Mons, Belgium.
  4. Evolutionary Biology & Ecology, Université Libre de Bruxelles, Avenue Paul Héger, CP 160/12, 1000 Brussels, Belgium.
  5. Department of Obstetrics and Gynecology, University of Cologne, Kerpener Strasse 34, 50931 Cologne, Germany.

PMID: 34884971 PMCID: PMC8658491 DOI: 10.3390/ijms222313164

Abstract

Male infertility is a common health problem that can be influenced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. These effects have been largely demonstrated on sperm parameters (e.g., motility, numeration, vitality, DNA integrity). In addition, several studies showed the deregulation of sperm proteins in relation to some of these factors. This review inventories the literature related to the identification of sperm proteins showing abundance variations in response to the four risk factors for male infertility that are the most investigated in this context: obesity, diabetes, tobacco smoking, and exposure to bisphenol-A (BPA). First, we provide an overview of the techniques used to identify deregulated proteins. Then, we summarise the main results obtained in the different studies and provide a compiled list of deregulated proteins in relation to each risk factor. Gene ontology analysis of these deregulated proteins shows that oxidative stress and immune and inflammatory responses are common mechanisms involved in sperm alterations encountered in relation to the risk factors.

Keywords: bisphenol-A; diabetes; infertility risk factors; obesity; proteins; proteomics; sperm; tobacco smoking

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