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Guan J, Hallberg B, Palmer RH. Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13235897.
Guan, J., Hallberg, B., & Palmer, R. H. (2021). Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future. Cancers, 13(23), . https://doi.org/10.3390/cancers13235897
Guan, Jikui, et al. "Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13235897
Guan J, Hallberg B, Palmer RH. Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future. Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235897. PMID: 34885007; PMCID: PMC8657310.
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Cancers (Basel). 2021 Nov 24;13(23). doi: 10.3390/cancers13235897.

Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future.

Cancers

Jikui Guan, Bengt Hallberg, Ruth H Palmer

Affiliations

  1. Department of Pediatric Oncology Surgery, Zhengzhou Key Laboratory of Precise Diagnosis and Treatment of Children's Malignant Tumors, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou 450018, China.
  2. Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 40530 Gothenburg, Sweden.

PMID: 34885007 PMCID: PMC8657310 DOI: 10.3390/cancers13235897

Abstract

Neuroblastoma is the most common extracranial solid pediatric tumor, with around 15% childhood cancer-related mortality. High-risk neuroblastomas exhibit a range of genetic, morphological, and clinical heterogeneities, which add complexity to diagnosis and treatment with existing modalities. Identification of novel therapies is a high priority in high-risk neuroblastoma, and the combination of genetic analysis with increased mechanistic understanding-including identification of key signaling and developmental events-provides optimism for the future. This focused review highlights several recent findings concerning chromosomes 1p, 2p, and 11q, which link genetic aberrations with aberrant molecular signaling output. These novel molecular insights contribute important knowledge towards more effective treatment strategies for neuroblastoma.

Keywords: ALK; ALKAL2; DLG2; MYCN; PHOX2B; haploinsufficiency

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