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Aksenova AY, Zhuk AS, Lada AG, et al. Genome Instability in Multiple Myeloma: Facts and Factors. Cancers (Basel). 2021;13(23)doi: 10.3390/cancers13235949.
Aksenova, A. Y., Zhuk, A. S., Lada, A. G., Zotova, I. V., Stepchenkova, E. I., Kostroma, I. I., Gritsaev, S. V., & Pavlov, Y. I. (2021). Genome Instability in Multiple Myeloma: Facts and Factors. Cancers, 13(23), . https://doi.org/10.3390/cancers13235949
Aksenova, Anna Y, et al. "Genome Instability in Multiple Myeloma: Facts and Factors." Cancers vol. 13,23 (2021). doi: https://doi.org/10.3390/cancers13235949
Aksenova AY, Zhuk AS, Lada AG, Zotova IV, Stepchenkova EI, Kostroma II, Gritsaev SV, Pavlov YI. Genome Instability in Multiple Myeloma: Facts and Factors. Cancers (Basel). 2021 Nov 26;13(23). doi: 10.3390/cancers13235949. PMID: 34885058; PMCID: PMC8656811.
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Cancers (Basel). 2021 Nov 26;13(23). doi: 10.3390/cancers13235949.

Genome Instability in Multiple Myeloma: Facts and Factors.

Cancers

Anna Y Aksenova, Anna S Zhuk, Artem G Lada, Irina V Zotova, Elena I Stepchenkova, Ivan I Kostroma, Sergey V Gritsaev, Youri I Pavlov

Affiliations

  1. Laboratory of Amyloid Biology, St. Petersburg State University, 199034 St. Petersburg, Russia.
  2. International Laboratory "Computer Technologies", ITMO University, 197101 St. Petersburg, Russia.
  3. Department of Microbiology and Molecular Genetics, University of California, Davis, CA 95616, USA.
  4. Department of Genetics and Biotechnology, St. Petersburg State University, 199034 St. Petersburg, Russia.
  5. Vavilov Institute of General Genetics, St. Petersburg Branch, Russian Academy of Sciences, 199034 St. Petersburg, Russia.
  6. Russian Research Institute of Hematology and Transfusiology, 191024 St. Petersburg, Russia.
  7. Eppley Institute for Research in Cancer, Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.
  8. Departments of Biochemistry and Molecular Biology, Microbiology and Pathology, Genetics Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198, USA.

PMID: 34885058 PMCID: PMC8656811 DOI: 10.3390/cancers13235949

Abstract

Multiple myeloma (MM) is a malignant neoplasm of terminally differentiated immunoglobulin-producing B lymphocytes called plasma cells. MM is the second most common hematologic malignancy, and it poses a heavy economic and social burden because it remains incurable and confers a profound disability to patients. Despite current progress in MM treatment, the disease invariably recurs, even after the transplantation of autologous hematopoietic stem cells (ASCT). Biological processes leading to a pathological myeloma clone and the mechanisms of further evolution of the disease are far from complete understanding. Genetically, MM is a complex disease that demonstrates a high level of heterogeneity. Myeloma genomes carry numerous genetic changes, including structural genome variations and chromosomal gains and losses, and these changes occur in combinations with point mutations affecting various cellular pathways, including genome maintenance. MM genome instability in its extreme is manifested in mutation

Keywords: DNA repair; chromothripsis; editing deaminases; genome instability; kataegis; multiple myeloma; translocations

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